| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 18 | 18 | 8 | 7 | 3.59 | .265 | 1.05 | 7.8 | 1.6 | 8.6 | 115.1 | 100 | 47 | 46 | 15 | 21 | 110 | 3 | 0 | 0 | 0 | 12 | 4 | 3 | 3.43 |
| SP | Halladay, R.Halladay, Roy † >> | 28 | 2005 | R | 85 | 17 | 17 | 11 | 4 | 3.82 | .283 | 1.15 | 8.0 | 2.4 | 5.9 | 113.0 | 100 | 50 | 48 | 18 | 30 | 74 | 2 | 0 | 0 | 1 | 11 | 4 | 2 | 4.66 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 71 | 17 | 17 | 6 | 6 | 6.75 | .378 | 1.79 | 10.7 | 5.4 | 6.2 | 84.0 | 100 | 72 | 63 | 10 | 50 | 58 | 0 | 0 | 0 | 0 | 6 | 3 | 2 | 5.06 |
| SP | Mussina, M.Mussina, Mike # >> | 33 | 2001 | R | 67 | 17 | 17 | 5 | 5 | 4.94 | .328 | 1.44 | 11.2 | 1.8 | 8.5 | 98.1 | 122 | 61 | 54 | 12 | 20 | 93 | 1 | 0 | 0 | 0 | 8 | 2 | 1 | 3.37 |
| SU | Percival, T.Percival, Troy >> | 38 | 2007 | R | 85 | 32 | 0 | 0 | 1 | 4.25 | .312 | 1.36 | 8.0 | 4.3 | 7.0 | 36.0 | 32 | 17 | 17 | 4 | 17 | 28 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 4.31 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 42 | 0 | 3 | 1 | 4.53 | .304 | 1.27 | 8.1 | 3.5 | 11.0 | 49.2 | 44 | 26 | 25 | 9 | 19 | 60 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 4.22 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 67 | 35 | 0 | 2 | 0 | 3.86 | .280 | 1.17 | 7.7 | 2.8 | 8.8 | 42.0 | 36 | 21 | 18 | 5 | 13 | 41 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.52 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 61 | 37 | 0 | 5 | 1 | 3.57 | .297 | 1.26 | 7.2 | 4.3 | 9.7 | 40.1 | 32 | 19 | 16 | 4 | 19 | 43 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.58 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 27 | 0 | 0 | 2 | 4.20 | .302 | 1.30 | 8.1 | 3.6 | 9.3 | 30.0 | 27 | 16 | 14 | 4 | 12 | 31 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.87 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 34 | 0 | 1 | 3 | 3.97 | .277 | 1.12 | 8.2 | 1.9 | 7.9 | 34.0 | 31 | 15 | 15 | 6 | 7 | 30 | 0 | 20 | 4 | 0 | 0 | 1 | 1 | 4.24 |
| RP | Urbina, U.Urbina, Ugueth >> | 28 | 2002 | R | 45 | 24 | 0 | 1 | 2 | 6.18 | .325 | 1.34 | 10.3 | 2.0 | 9.7 | 27.2 | 31 | 21 | 19 | 9 | 6 | 29 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 6.19 |