| SP | Johnson, R.Johnson, Randy † >> | 38 | 2001 | L | 97 | 33 | 33 | 12 | 8 | 3.57 | .287 | 1.18 | 7.2 | 3.5 | 11.0 | 216.2 | 173 | 87 | 86 | 25 | 83 | 263 | 5 | 0 | 0 | 2 | 20 | 6 | 5 | 3.31 |
| SP | Halladay, R.Halladay, Roy † >> | 28 | 2005 | R | 85 | 32 | 32 | 19 | 7 | 4.15 | .303 | 1.27 | 8.8 | 2.6 | 7.3 | 199.2 | 195 | 105 | 92 | 36 | 58 | 162 | 1 | 0 | 0 | 0 | 18 | 7 | 5 | 4.70 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 32 | 32 | 11 | 9 | 5.50 | .321 | 1.37 | 9.8 | 2.6 | 6.9 | 185.0 | 201 | 120 | 113 | 26 | 53 | 142 | 2 | 0 | 0 | 0 | 12 | 8 | 2 | 4.28 |
| SP | Maddux, G.Maddux, Greg # >> | 34 | 2000 | R | 58 | 32 | 31 | 12 | 7 | 5.42 | .324 | 1.40 | 10.8 | 1.8 | 6.8 | 171.0 | 205 | 108 | 103 | 33 | 35 | 129 | 4 | 0 | 0 | 1 | 11 | 6 | 2 | 4.72 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 32 | 32 | 12 | 12 | 5.27 | .344 | 1.57 | 11.5 | 2.6 | 6.0 | 170.2 | 218 | 106 | 100 | 34 | 50 | 114 | 0 | 0 | 0 | 0 | 15 | 1 | 4 | 5.16 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 68 | 86 | 0 | 8 | 4 | 3.97 | .280 | 1.16 | 6.9 | 3.5 | 6.9 | 102.0 | 78 | 45 | 45 | 8 | 40 | 78 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 3.70 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 64 | 0 | 2 | 3 | 4.26 | .294 | 1.25 | 7.8 | 3.5 | 8.6 | 69.2 | 60 | 36 | 33 | 10 | 27 | 66 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 4.14 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 48 | 0 | 2 | 2 | 4.78 | .352 | 1.57 | 9.7 | 4.4 | 9.9 | 49.0 | 53 | 27 | 26 | 5 | 24 | 54 | 0 | 13 | 2 | 0 | 0 | 3 | 5 | 3.78 |
| RP | Urbina, U.Urbina, Ugueth >> | 28 | 2002 | R | 45 | 26 | 0 | 4 | 3 | 5.28 | .365 | 1.66 | 12.4 | 2.5 | 8.4 | 29.0 | 40 | 17 | 17 | 5 | 8 | 27 | 0 | 0 | 1 | 0 | 0 | 2 | 3 | 4.41 |