| SP | Schmidt, J.Schmidt, Jason $ >> | 30 | 2003 | R | 99 | 13 | 13 | 4 | 3 | 3.75 | .256 | 1.02 | 6.9 | 2.3 | 9.0 | 86.1 | 66 | 36 | 36 | 7 | 22 | 86 | 2 | 0 | 0 | 1 | 7 | 1 | 1 | 2.86 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 13 | 13 | 5 | 4 | 5.86 | .316 | 1.37 | 8.6 | 3.9 | 5.8 | 70.2 | 67 | 48 | 46 | 14 | 30 | 45 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 5.64 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 13 | 13 | 4 | 6 | 6.56 | .340 | 1.51 | 11.2 | 2.4 | 7.1 | 70.0 | 87 | 52 | 51 | 19 | 19 | 55 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 5.86 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 13 | 13 | 3 | 5 | 6.00 | .357 | 1.62 | 11.1 | 3.5 | 6.0 | 60.0 | 74 | 45 | 40 | 14 | 23 | 40 | 0 | 0 | 0 | 0 | 4 | 3 | 2 | 6.00 |
| SU | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 28 | 0 | 1 | 0 | 5.02 | .289 | 1.15 | 9.0 | 1.6 | 7.1 | 28.2 | 28 | 16 | 16 | 8 | 5 | 22 | 0 | 2 | 2 | 0 | 0 | 2 | 2 | 5.89 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 30 | 0 | 3 | 1 | 6.00 | .391 | 1.93 | 7.7 | 9.7 | 11.0 | 27.0 | 23 | 18 | 18 | 5 | 29 | 33 | 0 | 1 | 2 | 0 | 0 | 0 | 3 | 6.19 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 78 | 22 | 0 | 3 | 1 | 2.67 | .257 | 1.04 | 6.7 | 2.7 | 10.0 | 27.0 | 20 | 8 | 8 | 3 | 8 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.11 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 30 | 0 | 2 | 0 | 2.14 | .213 | 0.81 | 6.0 | 1.3 | 9.0 | 21.0 | 14 | 5 | 5 | 2 | 3 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.67 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 14 | 0 | 0 | 0 | 1.88 | .271 | 1.12 | 5.8 | 4.5 | 9.6 | 14.1 | 9 | 3 | 3 | 0 | 7 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.36 |
| SP | Garcia, F.Garcia, Freddy >> | 26 | 2001 | R | 62 | 16 | 0 | 1 | 2 | 4.96 | .329 | 1.39 | 9.7 | 2.9 | 5.8 | 65.1 | 70 | 37 | 36 | 7 | 21 | 42 | 0 | 0 | 0 | 0 | 0 | 5 | 2 | 4.31 |