| SP | Arrieta, J.Arrieta, Jake >> | 36 | 2015 | R | 94 | 27 | 27 | 10 | 9 | 4.32 | .306 | 1.32 | 8.9 | 3.0 | 7.5 | 164.2 | 162 | 82 | 79 | 12 | 55 | 137 | 1 | 0 | 0 | 1 | 16 | 1 | 4 | 3.30 |
| SP | Hendricks, K.Hendricks, Kyle >> | 33 | 2016 | R | 89 | 27 | 27 | 13 | 8 | 4.28 | .308 | 1.30 | 9.0 | 2.7 | 6.3 | 162.0 | 162 | 82 | 77 | 20 | 48 | 113 | 2 | 0 | 0 | 0 | 14 | 6 | 3 | 4.21 |
| SP | Darvish, Y.Darvish, Yu >> | 36 | 2020 | R | 56 | 26 | 26 | 11 | 6 | 3.33 | .292 | 1.20 | 8.3 | 2.5 | 9.3 | 162.0 | 150 | 62 | 60 | 18 | 45 | 168 | 0 | 0 | 0 | 0 | 17 | 5 | 3 | 3.30 |
| RP | Grimm, J.Grimm, Justin >> | 33 | 2015 | R | 99 | 73 | 0 | 5 | 2 | 4.00 | .306 | 1.30 | 8.0 | 3.7 | 9.0 | 101.1 | 90 | 54 | 45 | 14 | 42 | 101 | 0 | 6 | 3 | 0 | 0 | 2 | 8 | 4.11 |
| RP | Chapman, A.Chapman, Aroldis >> | 35 | 2016 | L | 92 | 65 | 0 | 6 | 4 | 3.61 | .295 | 1.24 | 7.1 | 4.1 | 9.9 | 72.1 | 57 | 32 | 29 | 7 | 33 | 79 | 0 | 7 | 4 | 0 | 0 | 1 | 9 | 3.49 |
| RP | Edwards, C.Edwards, Carl >> | 31 | 2016 | R | 93 | 58 | 0 | 5 | 3 | 4.45 | .310 | 1.35 | 6.8 | 5.4 | 9.3 | 58.2 | 44 | 29 | 29 | 7 | 35 | 60 | 0 | 10 | 0 | 0 | 0 | 0 | 10 | 4.31 |
| RP | Chafin, A.Chafin, Andrew >> | 33 | 2021 | L | 87 | 38 | 0 | 4 | 3 | 2.82 | .268 | 1.07 | 7.6 | 2.3 | 7.2 | 44.2 | 37 | 14 | 14 | 3 | 11 | 35 | 0 | 3 | 3 | 0 | 0 | 1 | 5 | 3.11 |
| RP | Leiter, M.Leiter, Mark >> | 32 | 2023 | R | 65 | 33 | 0 | 4 | 2 | 4.46 | .318 | 1.37 | 8.2 | 4.2 | 9.8 | 34.1 | 31 | 17 | 17 | 5 | 16 | 37 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 4.24 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 35 | 2021 | R | 89 | 35 | 0 | 0 | 2 | 3.89 | .288 | 1.21 | 6.4 | 4.8 | 11.1 | 34.2 | 24 | 15 | 15 | 2 | 18 | 42 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 2.88 |
| RP | Tepera, R.Tepera, Ryan >> | 35 | 2021 | R | 90 | 34 | 0 | 0 | 0 | 2.93 | .242 | 0.96 | 5.7 | 2.9 | 10.0 | 46.0 | 29 | 15 | 15 | 6 | 15 | 51 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.46 |
| SP | Alzolay, A.Alzolay, Adbert >> | 28 | 2021 | R | 48 | 12 | 0 | 3 | 0 | 4.88 | .294 | 1.25 | 10.9 | 0.4 | 8.3 | 24.0 | 29 | 13 | 13 | 5 | 1 | 22 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.00 |