| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 99 | 10 | 10 | 5 | 3 | 4.12 | .326 | 1.41 | 9.3 | 3.4 | 11.3 | 63.1 | 65 | 29 | 29 | 5 | 24 | 79 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 2.81 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 84 | 10 | 10 | 2 | 5 | 6.02 | .365 | 1.70 | 12.3 | 3.1 | 7.2 | 49.1 | 67 | 33 | 33 | 11 | 17 | 39 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 5.43 |
| SP | Giolito, L.Giolito, Lucas >> | 24 | 2019 | R | 71 | 9 | 9 | 4 | 2 | 6.23 | .340 | 1.50 | 9.4 | 4.2 | 11.1 | 43.1 | 45 | 30 | 30 | 6 | 20 | 53 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 3.88 |
| SP | McHugh, C.McHugh, Collin >> | 27 | 2014 | R | 80 | 10 | 9 | 4 | 3 | 4.76 | .335 | 1.45 | 9.0 | 4.1 | 10.2 | 51.0 | 51 | 30 | 27 | 8 | 23 | 58 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 4.29 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 26 | 0 | 4 | 1 | 2.79 | .256 | 1.03 | 7.4 | 1.9 | 6.5 | 29.0 | 24 | 9 | 9 | 5 | 6 | 21 | 0 | 12 | 3 | 0 | 0 | 0 | 0 | 4.41 |
| RP | Miller, A.Miller, Andrew >> | 30 | 2015 | L | 84 | 30 | 0 | 1 | 0 | 2.56 | .291 | 1.23 | 7.0 | 4.4 | 11.6 | 31.2 | 24 | 9 | 9 | 3 | 15 | 40 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.13 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 74 | 28 | 0 | 3 | 1 | 4.31 | .288 | 1.21 | 7.8 | 3.2 | 10.7 | 31.1 | 27 | 15 | 15 | 6 | 11 | 37 | 0 | 0 | 1 | 0 | 0 | 0 | 5 | 4.19 |
| RP | Siegrist, K.Siegrist, Kevin >> | 23 | 2013 | L | 80 | 23 | 0 | 0 | 0 | 2.05 | .325 | 1.44 | 5.9 | 7.3 | 10.4 | 26.1 | 17 | 6 | 6 | 0 | 21 | 30 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.12 |
| SP | Castillo, L.Castillo, Luis >> | 26 | 2019 | R | 48 | 10 | 0 | 2 | 1 | 9.70 | .439 | 2.34 | 12.4 | 9.0 | 9.4 | 21.1 | 29 | 24 | 23 | 6 | 21 | 22 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 7.62 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 73 | 25 | 0 | 0 | 0 | 7.13 | .312 | 1.36 | 8.5 | 4.2 | 10.6 | 17.2 | 16 | 14 | 14 | 3 | 8 | 20 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.35 |