| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 99 | 12 | 12 | 4 | 6 | 3.16 | .279 | 1.14 | 7.0 | 3.3 | 8.6 | 85.1 | 66 | 31 | 30 | 10 | 31 | 81 | 3 | 0 | 0 | 1 | 8 | 2 | 2 | 3.79 |
| SP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 80 | 12 | 12 | 0 | 2 | 3.21 | .268 | 1.10 | 6.0 | 4.1 | 4.4 | 33.2 | 22 | 12 | 12 | 0 | 15 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.39 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 91 | 12 | 12 | 9 | 1 | 2.00 | .259 | 1.04 | 6.9 | 2.5 | 8.5 | 99.0 | 76 | 23 | 22 | 2 | 27 | 93 | 4 | 0 | 0 | 0 | 11 | 1 | 2 | 2.23 |
| SP | Perez, P.Perez, Pascual # >> | 31 | 1988 | R | 73 | 12 | 12 | 5 | 1 | 4.23 | .325 | 1.43 | 9.4 | 3.5 | 4.3 | 61.2 | 64 | 29 | 29 | 5 | 24 | 29 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 4.34 |
| SP | Nabholz, C.Nabholz, Chris >> | 23 | 1990 | L | 65 | 11 | 11 | 0 | 3 | 2.67 | .264 | 1.07 | 6.7 | 3.0 | 6.7 | 27.0 | 20 | 9 | 8 | 1 | 9 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 22 | 0 | 1 | 1 | 1.46 | .260 | 1.05 | 6.4 | 3.4 | 9.4 | 24.2 | 17 | 4 | 4 | 1 | 9 | 25 | 0 | 14 | 1 | 0 | 0 | 0 | 2 | 2.58 |
| SU | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 77 | 23 | 0 | 2 | 3 | 4.32 | .312 | 1.32 | 7.9 | 4.0 | 9.7 | 25.0 | 22 | 15 | 12 | 4 | 11 | 27 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.36 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 89 | 27 | 0 | 3 | 1 | 3.56 | .299 | 1.28 | 7.5 | 4.0 | 4.8 | 43.0 | 36 | 17 | 17 | 4 | 19 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.47 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 76 | 27 | 0 | 1 | 6 | 4.58 | .279 | 1.16 | 7.2 | 3.3 | 7.7 | 35.1 | 28 | 18 | 18 | 5 | 13 | 30 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.26 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 50 | 27 | 0 | 1 | 2 | 2.51 | .276 | 1.14 | 7.0 | 3.4 | 9.3 | 32.1 | 25 | 10 | 9 | 4 | 12 | 33 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.69 |
| RP | Valdez, S.Valdez, Sergio >> | 28 | 1992 | R | 42 | 22 | 0 | 1 | 0 | 6.65 | .337 | 1.52 | 10.3 | 3.9 | 4.7 | 21.2 | 24 | 16 | 16 | 4 | 9 | 11 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.71 |