| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 5 | 5 | 3 | 1 | 4.59 | .275 | 1.14 | 8.5 | 1.9 | 8.7 | 33.1 | 31 | 17 | 17 | 4 | 7 | 32 | 1 | 0 | 0 | 0 | 3 | 0 | 2 | 3.27 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 75 | 5 | 5 | 3 | 1 | 4.18 | .373 | 1.79 | 9.3 | 6.8 | 9.0 | 28.0 | 29 | 13 | 13 | 7 | 21 | 28 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 6.50 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 65 | 5 | 5 | 2 | 2 | 6.11 | .364 | 1.71 | 11.9 | 3.5 | 6.8 | 28.0 | 37 | 19 | 19 | 4 | 11 | 21 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4.54 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 51 | 5 | 5 | 2 | 1 | 3.13 | .326 | 1.45 | 9.6 | 3.8 | 6.7 | 31.2 | 33 | 13 | 11 | 3 | 13 | 23 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 4.03 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 96 | 13 | 0 | 1 | 0 | 2.57 | .232 | 0.90 | 6.0 | 2.1 | 9.9 | 21.0 | 14 | 6 | 6 | 1 | 5 | 23 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.14 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 12 | 0 | 1 | 0 | 2.57 | .311 | 1.36 | 9.0 | 3.2 | 11.6 | 14.0 | 14 | 4 | 4 | 0 | 5 | 18 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1.50 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 50 | 9 | 0 | 1 | 1 | 8.31 | .361 | 1.69 | 13.2 | 2.1 | 9.0 | 13.0 | 19 | 12 | 12 | 1 | 3 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.69 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 36 | 11 | 0 | 0 | 1 | 11.25 | .351 | 1.63 | 10.1 | 4.5 | 9.0 | 8.0 | 9 | 10 | 10 | 1 | 4 | 8 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 4.13 |
| RP | Cordero, F.Cordero, Francisco >> | 32 | 2007 | R | 25 | 9 | 0 | 0 | 0 | 6.97 | .367 | 1.74 | 12.6 | 3.6 | 12.6 | 10.1 | 14 | 8 | 8 | 2 | 4 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 38 | 1 | 0 | 0 | 0 | 20.25 | .500 | 3.00 | 27.0 | 9.0 | 9.0 | 1.1 | 3 | 3 | 3 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |