| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 17 | 17 | 7 | 3 | 3.44 | .269 | 1.10 | 7.4 | 2.5 | 7.7 | 117.2 | 96 | 48 | 45 | 12 | 33 | 100 | 1 | 0 | 0 | 1 | 12 | 1 | 2 | 3.50 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 80 | 16 | 16 | 2 | 9 | 8.07 | .389 | 1.85 | 12.5 | 4.1 | 9.5 | 87.0 | 121 | 79 | 78 | 26 | 40 | 92 | 0 | 0 | 0 | 0 | 4 | 5 | 3 | 6.32 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 16 | 16 | 8 | 5 | 4.82 | .312 | 1.34 | 9.6 | 2.5 | 7.2 | 93.1 | 99 | 52 | 50 | 16 | 26 | 74 | 1 | 0 | 0 | 1 | 6 | 2 | 4 | 4.55 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 16 | 16 | 3 | 9 | 6.99 | .346 | 1.57 | 11.7 | 2.6 | 7.8 | 95.1 | 123 | 74 | 74 | 21 | 27 | 82 | 3 | 0 | 0 | 0 | 3 | 1 | 1 | 5.03 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 54 | 16 | 16 | 7 | 5 | 7.69 | .366 | 1.68 | 12.0 | 3.1 | 6.9 | 96.0 | 128 | 83 | 82 | 21 | 33 | 74 | 1 | 0 | 0 | 0 | 2 | 5 | 6 | 5.49 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 35 | 0 | 3 | 1 | 3.42 | .290 | 1.20 | 8.8 | 2.1 | 9.6 | 47.1 | 46 | 19 | 18 | 4 | 11 | 50 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.74 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 30 | 0 | 2 | 1 | 4.91 | .322 | 1.30 | 7.6 | 4.1 | 8.2 | 33.0 | 28 | 18 | 18 | 8 | 15 | 30 | 0 | 0 | 1 | 0 | 0 | 4 | 1 | 6.06 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 100 | 28 | 0 | 3 | 2 | 2.41 | .205 | 0.77 | 4.4 | 2.7 | 12.0 | 33.2 | 16 | 9 | 9 | 2 | 10 | 44 | 0 | 14 | 2 | 0 | 0 | 0 | 0 | 2.03 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 85 | 25 | 0 | 2 | 2 | 3.49 | .280 | 1.16 | 7.4 | 3.2 | 5.8 | 28.1 | 23 | 11 | 11 | 3 | 10 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.18 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 29 | 0 | 0 | 1 | 2.25 | .270 | 1.11 | 7.5 | 2.5 | 8.0 | 36.0 | 30 | 9 | 9 | 7 | 10 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.58 |