| SP | Brown, K.Brown, Kevin $$ >> | 35 | 2000 | R | 91 | 30 | 30 | 11 | 12 | 3.90 | .299 | 1.26 | 8.7 | 2.7 | 7.5 | 191.1 | 184 | 88 | 83 | 29 | 58 | 159 | 0 | 0 | 0 | 0 | 19 | 3 | 3 | 4.27 |
| SP | Wakefield, T.Wakefield, Tim # >> | 36 | 2002 | R | 84 | 30 | 30 | 3 | 7 | 3.98 | .282 | 1.16 | 6.6 | 3.8 | 5.8 | 122.0 | 89 | 57 | 54 | 13 | 52 | 79 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4.44 |
| SP | Alvarez, W.Alvarez, Wilson # >> | 33 | 2003 | L | 74 | 29 | 29 | 6 | 10 | 6.32 | .342 | 1.51 | 10.5 | 3.2 | 6.5 | 129.2 | 150 | 91 | 91 | 17 | 46 | 93 | 0 | 0 | 0 | 0 | 3 | 6 | 4 | 4.48 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 28 | 28 | 11 | 10 | 4.28 | .316 | 1.34 | 9.6 | 2.5 | 5.6 | 174.1 | 185 | 98 | 83 | 35 | 49 | 109 | 3 | 0 | 0 | 0 | 16 | 8 | 3 | 5.34 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 94 | 64 | 0 | 3 | 6 | 2.42 | .271 | 1.10 | 6.6 | 3.5 | 9.9 | 70.2 | 51 | 21 | 19 | 10 | 27 | 77 | 0 | 30 | 4 | 0 | 0 | 1 | 0 | 3.86 |
| SU | Wagner, B.Wagner, Billy $$ >> | 32 | 2003 | L | 89 | 75 | 0 | 4 | 4 | 3.87 | .303 | 1.29 | 7.6 | 4.0 | 10.3 | 79.0 | 67 | 36 | 34 | 11 | 35 | 90 | 0 | 4 | 6 | 0 | 0 | 1 | 0 | 3.90 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 78 | 0 | 7 | 0 | 2.82 | .236 | 0.93 | 6.9 | 1.5 | 10.2 | 89.1 | 68 | 29 | 28 | 11 | 15 | 101 | 0 | 1 | 4 | 0 | 0 | 0 | 1 | 2.84 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 55 | 80 | 0 | 4 | 1 | 4.17 | .324 | 1.41 | 8.5 | 4.2 | 9.3 | 69.0 | 65 | 32 | 32 | 9 | 32 | 71 | 0 | 1 | 1 | 0 | 0 | 2 | 5 | 4.12 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 11 | 0 | 2 | 3 | 5.40 | .355 | 1.58 | 11.8 | 2.8 | 9.7 | 13.1 | 17 | 10 | 8 | 2 | 4 | 14 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.00 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 60 | 36 | 0 | 12 | 3 | 4.06 | .320 | 1.39 | 8.6 | 4.0 | 6.6 | 122.0 | 116 | 61 | 55 | 18 | 54 | 89 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 4.84 |