| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 17 | 17 | 11 | 3 | 2.61 | .255 | 0.99 | 7.3 | 1.7 | 9.9 | 124.1 | 100 | 38 | 36 | 9 | 23 | 137 | 5 | 0 | 0 | 2 | 13 | 5 | 2 | 2.41 |
| SP | Vazquez, J.Vazquez, Javier # >> | 33 | 2009 | R | 87 | 16 | 16 | 7 | 4 | 4.45 | .280 | 1.16 | 8.2 | 2.2 | 9.0 | 95.0 | 87 | 51 | 47 | 14 | 23 | 95 | 0 | 0 | 0 | 0 | 8 | 1 | 2 | 3.67 |
| SP | Greinke, Z.Greinke, Zack † >> | 26 | 2009 | R | 76 | 16 | 16 | 9 | 5 | 3.52 | .303 | 1.29 | 9.1 | 2.5 | 8.8 | 107.1 | 108 | 52 | 42 | 17 | 30 | 105 | 3 | 0 | 0 | 1 | 11 | 2 | 3 | 4.00 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 71 | 16 | 16 | 10 | 4 | 4.44 | .303 | 1.28 | 7.4 | 4.1 | 6.0 | 107.1 | 88 | 57 | 53 | 20 | 49 | 71 | 2 | 0 | 0 | 0 | 9 | 3 | 2 | 5.56 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 77 | 16 | 16 | 7 | 6 | 4.11 | .313 | 1.34 | 8.0 | 4.0 | 8.9 | 92.0 | 82 | 43 | 42 | 18 | 41 | 91 | 0 | 0 | 0 | 0 | 8 | 3 | 0 | 5.00 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 32 | 0 | 1 | 2 | 3.12 | .280 | 1.17 | 6.8 | 3.8 | 10.1 | 40.1 | 30 | 16 | 14 | 3 | 17 | 45 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.00 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 27 | 0 | 1 | 0 | 2.59 | .266 | 0.99 | 5.5 | 3.5 | 5.2 | 31.1 | 19 | 13 | 9 | 5 | 12 | 18 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 5.39 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 27 | 0 | 0 | 1 | 1.82 | .205 | 0.78 | 5.0 | 2.2 | 10.9 | 29.2 | 16 | 8 | 6 | 2 | 7 | 35 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.21 |
| CL | Soriano, R.Soriano, Rafael † >> | 24 | 2003 | R | 97 | 26 | 0 | 2 | 3 | 2.55 | .275 | 1.14 | 6.0 | 4.5 | 10.9 | 24.2 | 16 | 8 | 7 | 3 | 12 | 29 | 0 | 17 | 1 | 0 | 0 | 0 | 0 | 3.71 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 56 | 2 | 0 | 0 | 0 | 6.75 | .333 | 1.50 | 18.0 | 0.0 | 9.0 | 1.1 | 2 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.00 |