| SP | Buchholz, C.Buchholz, Clay >> | 30 | 2013 | R | 98 | 38 | 38 | 21 | 8 | 3.10 | .298 | 1.27 | 8.6 | 2.8 | 7.2 | 281.1 | 268 | 105 | 97 | 23 | 88 | 225 | 5 | 0 | 0 | 2 | 27 | 3 | 2 | 3.43 |
| SP | Beckett, J.Beckett, Josh # >> | 34 | 2011 | R | 91 | 37 | 37 | 19 | 10 | 4.13 | .279 | 1.16 | 8.3 | 2.1 | 7.0 | 248.1 | 228 | 119 | 114 | 34 | 59 | 192 | 5 | 0 | 0 | 2 | 20 | 2 | 2 | 3.97 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 33 | 2008 | R | 65 | 35 | 35 | 15 | 9 | 3.66 | .306 | 1.26 | 7.2 | 4.2 | 6.5 | 216.2 | 172 | 91 | 88 | 18 | 101 | 157 | 0 | 0 | 0 | 0 | 21 | 13 | 7 | 4.21 |
| RP | Uehara, K.Uehara, Koji >> | 39 | 2013 | R | 100 | 94 | 0 | 2 | 4 | 3.95 | .309 | 1.30 | 8.9 | 2.8 | 9.6 | 116.1 | 115 | 51 | 51 | 16 | 36 | 124 | 0 | 11 | 4 | 0 | 0 | 5 | 1 | 3.72 |
| RP | Tazawa, J.Tazawa, Junichi >> | 28 | 2012 | R | 80 | 54 | 0 | 7 | 4 | 3.10 | .312 | 1.33 | 9.6 | 2.4 | 8.0 | 61.0 | 65 | 22 | 21 | 5 | 16 | 54 | 0 | 6 | 3 | 0 | 0 | 2 | 0 | 3.18 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 34 | 2011 | R | 76 | 37 | 0 | 1 | 3 | 4.34 | .304 | 1.29 | 8.5 | 3.2 | 11.2 | 37.1 | 35 | 20 | 18 | 4 | 13 | 46 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 3.05 |
| RP | Aardsma, D.Aardsma, David # >> | 33 | 2009 | R | 70 | 30 | 0 | 2 | 0 | 4.78 | .311 | 1.35 | 8.3 | 4.1 | 12.2 | 37.2 | 34 | 20 | 20 | 4 | 17 | 50 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 3.08 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 31 | 2008 | R | 91 | 69 | 0 | 4 | 3 | 4.38 | .331 | 1.43 | 9.5 | 3.4 | 9.5 | 84.1 | 89 | 44 | 41 | 12 | 32 | 89 | 0 | 17 | 1 | 0 | 0 | 4 | 0 | 4.02 |
| SP | Wakefield, T.Wakefield, Tim # >> | 47 | 2008 | R | 23 | 32 | 32 | 9 | 13 | 4.09 | .329 | 1.45 | 8.7 | 4.4 | 6.5 | 180.1 | 174 | 89 | 82 | 24 | 87 | 129 | 0 | 0 | 0 | 0 | 14 | 4 | 10 | 4.82 |