| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 86 | 38 | 38 | 15 | 16 | 4.47 | .330 | 1.46 | 9.1 | 4.1 | 9.3 | 215.2 | 217 | 124 | 107 | 33 | 97 | 223 | 3 | 0 | 0 | 1 | 14 | 5 | 4 | 4.34 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 92 | 37 | 37 | 17 | 13 | 4.82 | .325 | 1.44 | 9.9 | 3.0 | 6.6 | 240.2 | 265 | 140 | 129 | 33 | 81 | 176 | 5 | 0 | 0 | 1 | 15 | 2 | 5 | 4.36 |
| SP | Skubal, T.Skubal, Tarik >> | 27 | 2024 | L | 95 | 36 | 36 | 12 | 7 | 4.94 | .329 | 1.45 | 9.9 | 3.2 | 9.2 | 198.2 | 218 | 119 | 109 | 30 | 71 | 203 | 0 | 0 | 0 | 0 | 17 | 3 | 3 | 4.04 |
| SP | Verlander, J.Verlander, Justin † >> | 28 | 2011 | R | 97 | 34 | 34 | 19 | 9 | 3.16 | .274 | 1.12 | 7.9 | 2.2 | 7.4 | 233.1 | 205 | 91 | 82 | 17 | 56 | 191 | 7 | 0 | 0 | 3 | 23 | 3 | 6 | 3.07 |
| SP | Lolich, M.Lolich, Mickey # >> | 28 | 1968 | L | 59 | 31 | 31 | 12 | 7 | 4.97 | .335 | 1.49 | 10.0 | 3.5 | 6.8 | 157.2 | 174 | 92 | 87 | 23 | 61 | 119 | 0 | 0 | 0 | 0 | 12 | 3 | 2 | 4.61 |
| CL | Greene, S.Greene, Shane † >> | 30 | 2019 | R | 86 | 73 | 0 | 5 | 3 | 1.87 | .260 | 1.04 | 6.3 | 3.0 | 9.0 | 77.0 | 54 | 20 | 16 | 5 | 26 | 77 | 0 | 46 | 4 | 0 | 0 | 1 | 0 | 2.90 |
| SU | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 64 | 56 | 0 | 1 | 4 | 6.40 | .340 | 1.53 | 11.0 | 3.0 | 7.7 | 64.2 | 78 | 53 | 46 | 12 | 21 | 55 | 0 | 6 | 9 | 0 | 0 | 1 | 0 | 4.75 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 70 | 93 | 0 | 6 | 2 | 4.01 | .296 | 1.23 | 6.8 | 4.4 | 5.6 | 116.2 | 87 | 55 | 52 | 10 | 57 | 72 | 0 | 2 | 4 | 0 | 0 | 3 | 8 | 4.43 |
| RP | Winter, G.Winter, George >> | 30 | 1908 | R | 42 | 72 | 0 | 13 | 3 | 3.77 | .318 | 1.39 | 10.0 | 2.6 | 5.9 | 131.1 | 145 | 60 | 55 | 11 | 38 | 86 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.67 |
| RP | Hiller, J.Hiller, John # >> | 24 | 1967 | L | 45 | 58 | 0 | 5 | 6 | 5.86 | .340 | 1.52 | 12.1 | 1.6 | 5.0 | 78.1 | 105 | 58 | 51 | 13 | 14 | 43 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 4.68 |
| RP | Benoit, J.Benoit, Joaquin >> | 34 | 2011 | R | 49 | 33 | 0 | 1 | 0 | 3.86 | .368 | 1.75 | 11.1 | 4.8 | 10.5 | 30.1 | 37 | 13 | 13 | 2 | 16 | 35 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.13 |
| RP | Miller, S.Miller, Shelby >> | 33 | 2024 | R | 56 | 39 | 0 | 0 | 0 | 4.28 | .290 | 1.23 | 8.1 | 2.9 | 5.4 | 40.0 | 36 | 23 | 19 | 7 | 13 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.05 |