| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 81 | 38 | 38 | 16 | 14 | 3.07 | .268 | 1.08 | 7.5 | 2.3 | 8.6 | 275.2 | 228 | 100 | 94 | 30 | 70 | 262 | 6 | 0 | 0 | 2 | 26 | 5 | 3 | 3.33 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 66 | 38 | 38 | 14 | 8 | 3.88 | .281 | 1.17 | 7.8 | 2.7 | 8.7 | 211.0 | 182 | 93 | 91 | 20 | 64 | 205 | 4 | 0 | 0 | 1 | 19 | 2 | 2 | 3.23 |
| SP | Lamet, D.Lamet, Dinelson >> | 27 | 2020 | R | 100 | 35 | 35 | 1 | 5 | 2.65 | .253 | 1.01 | 6.1 | 3.1 | 9.6 | 98.2 | 66 | 34 | 29 | 11 | 34 | 105 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.36 |
| SP | Pomeranz, D.Pomeranz, Drew >> | 27 | 2016 | L | 79 | 38 | 32 | 11 | 6 | 3.46 | .279 | 1.12 | 6.2 | 3.9 | 8.8 | 174.1 | 120 | 69 | 67 | 16 | 76 | 171 | 2 | 1 | 0 | 2 | 15 | 6 | 7 | 3.64 |
| SP | Paddack, C.Paddack, Chris # >> | 23 | 2019 | R | 78 | 32 | 32 | 6 | 14 | 5.49 | .332 | 1.49 | 10.0 | 3.4 | 8.0 | 142.2 | 158 | 88 | 87 | 21 | 54 | 127 | 0 | 0 | 0 | 0 | 6 | 1 | 2 | 4.30 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 100 | 105 | 0 | 15 | 2 | 1.59 | .217 | 0.82 | 4.7 | 2.7 | 8.0 | 158.0 | 83 | 31 | 28 | 7 | 47 | 140 | 0 | 7 | 3 | 0 | 0 | 1 | 1 | 2.72 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 99 | 93 | 0 | 8 | 7 | 2.56 | .284 | 1.15 | 6.3 | 4.1 | 9.9 | 126.1 | 88 | 42 | 36 | 9 | 57 | 139 | 0 | 3 | 5 | 0 | 0 | 5 | 2 | 3.20 |
| RP | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 95 | 86 | 0 | 7 | 6 | 2.73 | .273 | 1.12 | 6.9 | 3.2 | 8.8 | 118.2 | 91 | 40 | 36 | 7 | 42 | 115 | 0 | 10 | 6 | 0 | 0 | 1 | 4 | 2.92 |
| RP | Meredith, C.Meredith, Cla >> | 23 | 2006 | R | 83 | 80 | 0 | 6 | 3 | 1.48 | .225 | 0.87 | 5.8 | 2.1 | 5.5 | 115.2 | 74 | 23 | 19 | 3 | 27 | 70 | 0 | 10 | 2 | 0 | 0 | 0 | 0 | 2.83 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 82 | 54 | 0 | 5 | 2 | 2.86 | .257 | 1.02 | 6.3 | 3.0 | 7.7 | 69.1 | 48 | 23 | 22 | 7 | 23 | 59 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 3.65 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 87 | 63 | 0 | 9 | 4 | 3.42 | .301 | 1.28 | 8.0 | 3.5 | 8.8 | 79.0 | 70 | 32 | 30 | 5 | 31 | 77 | 0 | 4 | 1 | 0 | 0 | 1 | 4 | 3.09 |