| SP | McLain, D.McLain, Denny † >> | 24 | 1968 | R | 84 | 34 | 34 | 17 | 11 | 3.25 | .282 | 1.15 | 7.6 | 2.8 | 5.6 | 257.2 | 217 | 96 | 93 | 16 | 79 | 159 | 17 | 0 | 0 | 3 | 20 | 7 | 1 | 3.58 |
| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 86 | 33 | 33 | 17 | 9 | 2.84 | .278 | 1.13 | 7.4 | 2.8 | 8.7 | 215.2 | 177 | 71 | 68 | 12 | 66 | 207 | 0 | 0 | 0 | 0 | 24 | 6 | 0 | 2.80 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 75 | 35 | 35 | 15 | 8 | 4.19 | .319 | 1.40 | 9.4 | 3.2 | 8.8 | 223.1 | 233 | 110 | 104 | 23 | 79 | 218 | 2 | 0 | 0 | 0 | 19 | 2 | 3 | 3.48 |
| SP | Lolich, M.Lolich, Mickey >> | 28 | 1968 | L | 52 | 31 | 31 | 10 | 10 | 5.28 | .340 | 1.52 | 9.8 | 3.9 | 6.5 | 138.0 | 150 | 85 | 81 | 22 | 60 | 99 | 0 | 0 | 0 | 0 | 10 | 3 | 2 | 5.01 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 81 | 87 | 0 | 4 | 5 | 2.81 | .288 | 1.19 | 6.5 | 4.3 | 8.5 | 118.2 | 85 | 41 | 37 | 13 | 56 | 112 | 0 | 7 | 4 | 0 | 0 | 3 | 0 | 4.03 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 68 | 81 | 0 | 6 | 2 | 3.93 | .319 | 1.40 | 7.3 | 5.4 | 10.5 | 94.0 | 76 | 43 | 41 | 6 | 56 | 110 | 0 | 7 | 1 | 0 | 0 | 0 | 3 | 3.28 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 57 | 69 | 0 | 4 | 8 | 3.84 | .307 | 1.30 | 6.9 | 4.8 | 5.9 | 103.0 | 79 | 47 | 44 | 9 | 55 | 68 | 0 | 7 | 5 | 0 | 0 | 3 | 6 | 4.50 |
| RP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 49 | 53 | 0 | 4 | 2 | 4.26 | .323 | 1.41 | 10.3 | 2.4 | 6.4 | 76.0 | 87 | 36 | 36 | 11 | 20 | 54 | 0 | 12 | 2 | 0 | 0 | 2 | 0 | 4.33 |
| RP | Miller, S.Miller, Shelby >> | 33 | 2024 | R | 41 | 26 | 0 | 2 | 1 | 4.75 | .300 | 1.25 | 9.3 | 2.1 | 7.2 | 30.1 | 31 | 16 | 16 | 8 | 7 | 24 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 5.67 |
| RP | Podres, J.Podres, Johnny >> | 35 | 1967 | L | 28 | 22 | 0 | 5 | 1 | 4.66 | .293 | 1.24 | 8.4 | 2.8 | 5.3 | 29.0 | 27 | 16 | 15 | 2 | 9 | 17 | 0 | 2 | 0 | 0 | 0 | 0 | 3 | 3.66 |
| SP | Gausman, K.Gausman, Kevin >> | 33 | 2024 | R | 38 | 3 | 0 | 0 | 0 | 3.00 | .357 | 1.33 | 6.0 | 6.0 | 9.0 | 3.0 | 2 | 1 | 1 | 0 | 2 | 3 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.00 |