| SP | Skubal, T.Skubal, Tarik >> | 27 | 2024 | L | 86 | 23 | 23 | 10 | 9 | 3.69 | .285 | 1.18 | 8.4 | 2.4 | 8.2 | 153.2 | 142 | 70 | 63 | 13 | 40 | 140 | 0 | 0 | 0 | 0 | 15 | 2 | 3 | 3.10 |
| SP | Verlander, J.Verlander, Justin † >> | 28 | 2011 | R | 90 | 22 | 22 | 12 | 7 | 3.17 | .279 | 1.14 | 7.7 | 2.6 | 6.5 | 167.1 | 142 | 65 | 59 | 13 | 48 | 121 | 7 | 0 | 0 | 3 | 13 | 4 | 3 | 3.50 |
| SP | Liriano, F.Liriano, Francisco >> | 35 | 2018 | L | 16 | 13 | 11 | 3 | 7 | 8.12 | .394 | 1.86 | 11.0 | 5.8 | 4.7 | 54.1 | 66 | 52 | 49 | 7 | 35 | 28 | 0 | 0 | 0 | 0 | 0 | 5 | 2 | 5.87 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 80 | 21 | 21 | 3 | 10 | 5.05 | .343 | 1.54 | 10.6 | 3.3 | 9.1 | 137.1 | 162 | 80 | 77 | 10 | 50 | 138 | 1 | 0 | 0 | 0 | 6 | 3 | 3 | 3.09 |
| SP | Morris, J.Morris, Jack >> | 31 | 1986 | R | 48 | 20 | 20 | 8 | 6 | 4.83 | .349 | 1.60 | 10.2 | 4.2 | 6.9 | 130.1 | 148 | 76 | 70 | 14 | 61 | 100 | 3 | 0 | 0 | 0 | 11 | 1 | 9 | 4.29 |
| RP | Karsay, S.Karsay, Steve >> | 29 | 2001 | R | 34 | 14 | 0 | 0 | 0 | 2.84 | .296 | 1.21 | 8.1 | 2.8 | 7.1 | 19.0 | 17 | 6 | 6 | 2 | 6 | 15 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.89 |
| RP | Hernandez, W.Hernandez, Willie # >> | 33 | 1987 | L | 12 | 46 | 0 | 3 | 4 | 5.57 | .335 | 1.45 | 9.5 | 3.7 | 5.5 | 51.2 | 54 | 37 | 32 | 12 | 21 | 31 | 0 | 7 | 2 | 0 | 0 | 3 | 1 | 6.25 |
| RP | Van Poppel, T.Van Poppel, Todd >> | 25 | 1996 | R | 1 | 28 | 0 | 0 | 5 | 6.26 | .427 | 2.18 | 11.4 | 8.6 | 4.4 | 41.2 | 52 | 39 | 29 | 8 | 39 | 20 | 0 | 3 | 2 | 0 | 0 | 2 | 3 | 7.56 |
| RP | Hanifee, B.Hanifee, Brenan >> | 27 | 2025 | R | 19 | 36 | 0 | 3 | 1 | 4.64 | .323 | 1.41 | 9.9 | 3.0 | 5.1 | 42.2 | 46 | 22 | 22 | 2 | 14 | 24 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 3.55 |
| RP | Sparks, S.Sparks, Steve >> | 38 | 2003 | R | 15 | 19 | 0 | 0 | 2 | 3.63 | .288 | 1.18 | 8.5 | 2.4 | 5.3 | 34.2 | 32 | 16 | 14 | 5 | 9 | 20 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.62 |
| SP | Newhouser, H.Newhouser, Hal # >> | 23 | 1944 | L | 46 | 12 | 11 | 3 | 5 | 7.29 | .356 | 1.64 | 11.0 | 3.7 | 5.0 | 58.0 | 71 | 47 | 47 | 9 | 24 | 32 | 1 | 0 | 0 | 1 | 3 | 1 | 0 | 5.21 |
| RP | Patterson, D.Patterson, Danny >> | 33 | 2004 | R | 14 | 20 | 0 | 1 | 0 | 5.91 | .319 | 1.41 | 6.0 | 6.9 | 7.3 | 21.1 | 14 | 14 | 14 | 0 | 16 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.67 |