| SP | Jimenez, U.Jimenez, Ubaldo # >> | 26 | 2010 | R | 55 | 23 | 23 | 7 | 8 | 4.80 | .324 | 1.41 | 8.2 | 4.6 | 5.5 | 138.2 | 125 | 77 | 74 | 10 | 70 | 84 | 0 | 0 | 0 | 0 | 10 | 4 | 8 | 4.33 |
| SP | Marquez, G.Marquez, German >> | 23 | 2018 | R | 43 | 22 | 22 | 5 | 9 | 6.20 | .343 | 1.53 | 10.5 | 3.3 | 8.9 | 103.0 | 120 | 72 | 71 | 21 | 38 | 102 | 0 | 0 | 0 | 0 | 8 | 3 | 4 | 4.86 |
| SP | Gomber, A.Gomber, Austin >> | 27 | 2021 | L | 40 | 22 | 22 | 5 | 11 | 5.04 | .345 | 1.53 | 10.0 | 3.8 | 5.2 | 103.2 | 115 | 63 | 58 | 12 | 44 | 59 | 0 | 0 | 0 | 0 | 4 | 5 | 1 | 4.80 |
| SP | Chacin, J.Chacin, Jhoulys >> | 22 | 2010 | R | 42 | 21 | 21 | 7 | 3 | 5.64 | .339 | 1.49 | 9.2 | 4.3 | 6.4 | 99.0 | 101 | 63 | 62 | 16 | 47 | 70 | 0 | 0 | 0 | 0 | 4 | 4 | 1 | 5.23 |
| RP | Ottavino, A.Ottavino, Adam † # >> | 32 | 2018 | R | 69 | 56 | 0 | 8 | 3 | 3.40 | .277 | 1.13 | 5.9 | 4.4 | 9.7 | 76.2 | 50 | 31 | 29 | 6 | 37 | 82 | 0 | 4 | 2 | 0 | 0 | 1 | 2 | 3.37 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 65 | 58 | 0 | 6 | 5 | 3.18 | .280 | 1.14 | 8.5 | 1.8 | 8.4 | 73.2 | 69 | 30 | 26 | 9 | 15 | 68 | 0 | 10 | 4 | 0 | 0 | 2 | 2 | 3.44 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 61 | 38 | 0 | 4 | 4 | 4.66 | .300 | 1.28 | 7.9 | 3.8 | 8.6 | 48.1 | 42 | 26 | 25 | 7 | 20 | 46 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 4.23 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 63 | 36 | 0 | 3 | 2 | 3.35 | .309 | 1.34 | 7.9 | 4.3 | 7.2 | 40.1 | 35 | 15 | 15 | 3 | 19 | 32 | 0 | 8 | 1 | 0 | 0 | 0 | 4 | 3.80 |
| RP | DeJean, M.DeJean, Mike >> | 35 | 2005 | R | 45 | 25 | 0 | 1 | 0 | 1.75 | .374 | 1.75 | 8.6 | 7.6 | 5.8 | 25.2 | 24 | 5 | 5 | 0 | 21 | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 4.36 |
| SP | De La Rosa, J.De La Rosa, Jorge >> | 29 | 2010 | L | 31 | 23 | 0 | 2 | 0 | 5.89 | .359 | 1.68 | 10.3 | 4.9 | 6.0 | 91.2 | 104 | 62 | 60 | 11 | 50 | 61 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 4.88 |