| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 98 | 23 | 23 | 8 | 10 | 3.03 | .282 | 1.17 | 7.8 | 2.8 | 8.0 | 160.1 | 139 | 59 | 54 | 9 | 49 | 142 | 4 | 0 | 0 | 1 | 16 | 1 | 4 | 2.89 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 87 | 22 | 22 | 11 | 7 | 3.62 | .284 | 1.17 | 7.9 | 2.7 | 4.8 | 149.0 | 130 | 67 | 60 | 13 | 44 | 79 | 3 | 0 | 0 | 1 | 15 | 3 | 5 | 4.02 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 79 | 22 | 22 | 9 | 7 | 4.02 | .294 | 1.24 | 8.2 | 3.0 | 5.6 | 145.2 | 132 | 70 | 65 | 10 | 48 | 91 | 6 | 0 | 0 | 0 | 12 | 2 | 5 | 3.68 |
| SP | Reulbach, E.Reulbach, Ed # >> | 24 | 1906 | R | 75 | 21 | 21 | 7 | 10 | 4.97 | .361 | 1.67 | 10.2 | 4.9 | 5.4 | 117.2 | 132 | 69 | 65 | 8 | 64 | 70 | 0 | 0 | 0 | 0 | 10 | 3 | 1 | 4.41 |
| SP | Dempster, R.Dempster, Ryan >> | 35 | 2012 | R | 59 | 21 | 21 | 4 | 7 | 5.43 | .334 | 1.49 | 10.1 | 3.4 | 4.5 | 117.2 | 131 | 73 | 71 | 18 | 44 | 59 | 0 | 0 | 0 | 0 | 9 | 2 | 0 | 5.17 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 100 | 42 | 0 | 3 | 3 | 5.53 | .362 | 1.70 | 7.7 | 7.7 | 12.2 | 42.1 | 36 | 26 | 26 | 3 | 36 | 57 | 0 | 22 | 3 | 0 | 0 | 0 | 6 | 3.79 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 96 | 59 | 0 | 2 | 1 | 2.47 | .284 | 1.19 | 5.7 | 5.1 | 10.6 | 73.0 | 46 | 21 | 20 | 4 | 41 | 86 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 3.04 |
| RP | Hodge, P.Hodge, Porter >> | 23 | 2024 | R | 87 | 43 | 0 | 6 | 1 | 3.33 | .328 | 1.44 | 8.8 | 4.2 | 7.9 | 51.1 | 50 | 24 | 19 | 6 | 24 | 45 | 0 | 1 | 5 | 0 | 0 | 1 | 3 | 4.24 |
| RP | Chafin, A.Chafin, Andrew >> | 31 | 2021 | L | 83 | 40 | 0 | 2 | 2 | 3.26 | .353 | 1.64 | 8.6 | 6.1 | 5.4 | 47.0 | 45 | 23 | 17 | 3 | 32 | 28 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 4.68 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 79 | 32 | 0 | 3 | 2 | 4.81 | .341 | 1.50 | 7.6 | 6.0 | 9.5 | 39.1 | 33 | 25 | 21 | 4 | 26 | 41 | 0 | 1 | 2 | 0 | 0 | 2 | 5 | 4.38 |
| RP | Chavez, J.Chavez, Jesse >> | 35 | 2018 | R | 77 | 26 | 0 | 3 | 1 | 5.46 | .346 | 1.58 | 12.4 | 2.2 | 6.5 | 29.2 | 40 | 21 | 18 | 1 | 7 | 21 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 2.72 |