| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 5 | 5 | 3 | 1 | 5.14 | .333 | 1.50 | 10.9 | 2.6 | 10.6 | 28.0 | 34 | 20 | 16 | 6 | 8 | 33 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4.29 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 4 | 4 | 0 | 1 | 4.13 | .314 | 1.33 | 6.8 | 5.3 | 6.8 | 24.0 | 18 | 11 | 11 | 3 | 14 | 18 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 5.00 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 4 | 4 | 2 | 0 | 4.39 | .298 | 1.24 | 9.0 | 2.4 | 9.0 | 26.2 | 26 | 16 | 13 | 3 | 7 | 26 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 3.42 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 13 | 0 | 0 | 1 | 7.71 | .333 | 1.50 | 11.6 | 1.9 | 10.3 | 14.0 | 18 | 12 | 12 | 3 | 3 | 16 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 4.14 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 12 | 0 | 0 | 1 | 6.57 | .302 | 1.22 | 11.3 | 0.0 | 6.8 | 12.1 | 15 | 9 | 9 | 3 | 0 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.00 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 10 | 0 | 2 | 1 | 3.55 | .283 | 1.11 | 8.3 | 2.3 | 9.8 | 12.2 | 11 | 7 | 5 | 1 | 3 | 13 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 2.92 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 14 | 0 | 0 | 0 | 2.70 | .310 | 1.35 | 9.0 | 3.5 | 4.8 | 13.1 | 13 | 4 | 4 | 0 | 5 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.08 |