| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 97 | 19 | 19 | 12 | 4 | 3.22 | .279 | 1.14 | 7.3 | 3.0 | 8.0 | 139.2 | 112 | 54 | 50 | 11 | 47 | 123 | 2 | 0 | 0 | 1 | 12 | 3 | 2 | 3.34 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 18 | 18 | 10 | 4 | 2.64 | .242 | 0.95 | 7.2 | 1.4 | 6.1 | 129.2 | 103 | 40 | 38 | 7 | 20 | 88 | 3 | 0 | 0 | 1 | 14 | 1 | 1 | 2.83 |
| SP | Mathewson, C.Mathewson, Christy † $ >> | 28 | 1908 | R | 83 | 20 | 19 | 11 | 5 | 3.48 | .240 | 0.93 | 6.9 | 1.5 | 4.6 | 132.0 | 101 | 54 | 51 | 19 | 22 | 68 | 4 | 0 | 0 | 0 | 12 | 2 | 4 | 4.39 |
| SP | Cicotte, E.Cicotte, Eddie † >> | 33 | 1917 | R | 74 | 18 | 18 | 11 | 4 | 3.53 | .278 | 1.14 | 7.2 | 3.1 | 4.2 | 132.2 | 105 | 52 | 52 | 8 | 46 | 62 | 5 | 0 | 0 | 1 | 11 | 2 | 0 | 3.94 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 42 | 0 | 3 | 2 | 2.72 | .224 | 0.85 | 6.5 | 1.2 | 8.5 | 53.0 | 38 | 16 | 16 | 4 | 7 | 50 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 2.55 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 29 | 0 | 3 | 0 | 2.48 | .268 | 1.10 | 6.3 | 3.8 | 5.8 | 36.1 | 25 | 13 | 10 | 4 | 15 | 23 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.42 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 21 | 0 | 2 | 1 | 3.60 | .318 | 1.35 | 8.6 | 3.6 | 6.3 | 20.0 | 19 | 8 | 8 | 1 | 8 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.60 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 7 | 0 | 0 | 3 | 3.97 | .364 | 1.72 | 9.8 | 6.1 | 5.7 | 22.2 | 24 | 10 | 10 | 0 | 15 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.77 |
| CL | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 35 | 0 | 0 | 4 | 4.46 | .270 | 1.05 | 5.8 | 3.7 | 9.8 | 34.1 | 22 | 17 | 17 | 2 | 14 | 37 | 0 | 20 | 4 | 0 | 0 | 2 | 4 | 3.00 |