| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 11 | 11 | 5 | 4 | 3.54 | .285 | 1.17 | 8.4 | 2.2 | 9.0 | 73.2 | 68 | 30 | 29 | 6 | 18 | 73 | 2 | 0 | 0 | 1 | 7 | 2 | 0 | 2.89 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 11 | 11 | 7 | 3 | 4.50 | .279 | 1.15 | 8.0 | 2.3 | 6.7 | 74.0 | 66 | 39 | 37 | 11 | 19 | 55 | 1 | 0 | 0 | 0 | 5 | 1 | 1 | 4.26 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 10 | 10 | 3 | 5 | 6.35 | .331 | 1.46 | 10.4 | 2.9 | 5.8 | 56.2 | 65 | 41 | 40 | 6 | 18 | 36 | 2 | 0 | 0 | 2 | 3 | 1 | 0 | 4.13 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 10 | 10 | 4 | 4 | 4.36 | .319 | 1.36 | 9.0 | 3.2 | 5.6 | 64.0 | 64 | 31 | 31 | 5 | 23 | 40 | 3 | 0 | 0 | 2 | 4 | 3 | 0 | 3.98 |
| CL | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 23 | 0 | 1 | 3 | 3.57 | .299 | 1.24 | 6.5 | 4.9 | 8.2 | 22.2 | 16 | 10 | 9 | 5 | 12 | 20 | 0 | 9 | 0 | 0 | 0 | 1 | 0 | 5.91 |
| SU | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 21 | 0 | 0 | 2 | 3.91 | .258 | 1.04 | 6.3 | 3.1 | 3.5 | 23.0 | 16 | 10 | 10 | 5 | 8 | 9 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 6.09 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 77 | 25 | 0 | 2 | 0 | 3.09 | .294 | 1.25 | 8.2 | 3.1 | 10.1 | 32.0 | 29 | 15 | 11 | 2 | 11 | 36 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.59 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 75 | 22 | 0 | 1 | 0 | 6.75 | .333 | 1.46 | 10.0 | 3.5 | 6.9 | 26.2 | 29 | 21 | 20 | 5 | 10 | 20 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.23 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 14 | 0 | 1 | 0 | 9.53 | .407 | 1.94 | 12.2 | 5.3 | 10.1 | 17.0 | 23 | 19 | 18 | 8 | 10 | 19 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 9.00 |