| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 26 | 26 | 9 | 10 | 4.20 | .297 | 1.22 | 9.4 | 1.6 | 5.7 | 158.2 | 165 | 87 | 74 | 22 | 28 | 100 | 3 | 0 | 0 | 1 | 15 | 8 | 0 | 4.23 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 26 | 25 | 1 | 15 | 9.98 | .416 | 2.11 | 14.6 | 4.4 | 8.0 | 98.1 | 159 | 114 | 109 | 30 | 48 | 87 | 0 | 0 | 0 | 0 | 3 | 3 | 7 | 6.77 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 25 | 25 | 6 | 9 | 6.43 | .380 | 1.81 | 10.0 | 6.3 | 7.8 | 119.0 | 132 | 97 | 85 | 17 | 83 | 103 | 0 | 0 | 0 | 0 | 8 | 4 | 3 | 5.32 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 80 | 72 | 0 | 3 | 4 | 3.47 | .308 | 1.32 | 7.5 | 4.5 | 8.0 | 72.2 | 60 | 33 | 28 | 7 | 36 | 64 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 4.03 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 61 | 0 | 5 | 9 | 4.12 | .339 | 1.52 | 10.1 | 3.8 | 9.1 | 67.2 | 75 | 37 | 31 | 11 | 28 | 68 | 0 | 1 | 11 | 0 | 0 | 1 | 1 | 4.40 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 59 | 0 | 4 | 2 | 3.76 | .289 | 1.21 | 9.0 | 2.0 | 7.0 | 64.2 | 64 | 29 | 27 | 4 | 14 | 50 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.95 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 55 | 0 | 4 | 5 | 3.02 | .311 | 1.34 | 7.2 | 5.0 | 8.4 | 65.2 | 52 | 22 | 22 | 5 | 36 | 61 | 0 | 21 | 2 | 0 | 0 | 1 | 0 | 3.83 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 42 | 0 | 0 | 0 | 2.98 | .296 | 1.26 | 6.8 | 4.7 | 9.9 | 48.1 | 36 | 16 | 16 | 3 | 25 | 53 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.17 |