| SP | Jimenez, U.Jimenez, Ubaldo # >> | 26 | 2010 | R | 56 | 23 | 23 | 10 | 9 | 4.23 | .306 | 1.30 | 8.4 | 3.3 | 7.5 | 163.2 | 153 | 82 | 77 | 21 | 60 | 135 | 4 | 0 | 0 | 1 | 13 | 4 | 7 | 4.20 |
| SP | Chacin, J.Chacin, Jhoulys >> | 22 | 2010 | R | 50 | 22 | 22 | 6 | 12 | 6.59 | .371 | 1.77 | 11.0 | 5.0 | 7.5 | 99.2 | 121 | 76 | 73 | 14 | 55 | 83 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 4.83 |
| SP | Marquez, G.Marquez, German >> | 26 | 2021 | R | 41 | 22 | 22 | 10 | 6 | 4.99 | .323 | 1.41 | 9.8 | 3.0 | 6.2 | 128.0 | 139 | 72 | 71 | 20 | 42 | 88 | 0 | 0 | 0 | 0 | 11 | 2 | 4 | 4.69 |
| SP | De La Rosa, J.De La Rosa, Jorge # >> | 29 | 2010 | L | 39 | 22 | 22 | 6 | 10 | 6.26 | .376 | 1.78 | 10.6 | 5.5 | 6.4 | 125.0 | 147 | 93 | 87 | 26 | 76 | 89 | 0 | 0 | 0 | 0 | 8 | 3 | 5 | 6.18 |
| SP | Bettis, C.Bettis, Chad >> | 26 | 2015 | R | 25 | 21 | 21 | 5 | 9 | 7.46 | .360 | 1.68 | 11.5 | 3.6 | 4.5 | 113.1 | 145 | 94 | 94 | 19 | 45 | 56 | 0 | 0 | 0 | 0 | 7 | 1 | 4 | 5.42 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 69 | 57 | 0 | 5 | 1 | 1.90 | .248 | 0.99 | 7.2 | 1.7 | 7.9 | 90.0 | 72 | 22 | 19 | 9 | 17 | 79 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 3.11 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 59 | 64 | 0 | 4 | 1 | 2.50 | .261 | 1.03 | 6.2 | 3.1 | 8.2 | 75.2 | 52 | 21 | 21 | 2 | 26 | 68 | 0 | 11 | 2 | 0 | 0 | 2 | 4 | 2.65 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 54 | 44 | 0 | 3 | 0 | 3.44 | .287 | 1.19 | 7.2 | 3.7 | 7.2 | 49.2 | 39 | 20 | 19 | 3 | 20 | 39 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 3.49 |
| RP | Buchholz, T.Buchholz, Taylor >> | 27 | 2008 | R | 48 | 31 | 0 | 3 | 1 | 1.82 | .268 | 1.07 | 7.4 | 2.4 | 7.1 | 34.2 | 28 | 7 | 7 | 1 | 9 | 27 | 0 | 3 | 0 | 0 | 0 | 1 | 2 | 2.68 |
| RP | Witasick, J.Witasick, Jay >> | 33 | 2005 | R | 33 | 26 | 0 | 0 | 2 | 3.26 | .331 | 1.48 | 9.6 | 3.9 | 7.2 | 30.1 | 32 | 11 | 11 | 2 | 13 | 24 | 0 | 2 | 0 | 0 | 0 | 0 | 3 | 3.57 |