| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 34 | 34 | 24 | 6 | 2.38 | .264 | 1.07 | 6.8 | 2.8 | 6.5 | 238.0 | 179 | 69 | 63 | 12 | 75 | 171 | 3 | 0 | 0 | 0 | 27 | 2 | 2 | 3.19 |
| SP | Steele, E.Steele, Elmer † >> | 22 | 1908 | R | 78 | 33 | 33 | 18 | 10 | 3.50 | .286 | 1.20 | 8.5 | 2.3 | 5.1 | 262.1 | 247 | 108 | 102 | 26 | 67 | 149 | 11 | 0 | 0 | 4 | 21 | 2 | 0 | 3.94 |
| SP | Martinez, P.Martinez, Pedro >> | 30 | 2001 | R | 82 | 31 | 31 | 16 | 10 | 4.28 | .314 | 1.36 | 9.7 | 2.6 | 9.9 | 201.2 | 217 | 98 | 96 | 22 | 58 | 221 | 1 | 0 | 0 | 0 | 19 | 2 | 5 | 3.12 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 98 | 87 | 0 | 3 | 0 | 2.89 | .290 | 1.22 | 6.5 | 4.5 | 8.5 | 102.2 | 74 | 38 | 33 | 6 | 51 | 96 | 0 | 4 | 3 | 0 | 0 | 1 | 5 | 3.41 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 94 | 85 | 0 | 5 | 3 | 3.64 | .292 | 1.24 | 7.7 | 3.6 | 9.2 | 76.2 | 65 | 31 | 31 | 9 | 30 | 78 | 0 | 11 | 2 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Brasier, R.Brasier, Ryan >> | 30 | 2018 | R | 86 | 44 | 0 | 4 | 2 | 3.73 | .293 | 1.22 | 7.7 | 3.3 | 5.9 | 41.0 | 35 | 17 | 17 | 6 | 15 | 27 | 0 | 10 | 1 | 0 | 0 | 1 | 0 | 4.76 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 76 | 54 | 0 | 4 | 1 | 1.93 | .252 | 1.01 | 6.5 | 2.8 | 9.6 | 32.2 | 23 | 9 | 7 | 4 | 10 | 34 | 0 | 7 | 3 | 0 | 0 | 0 | 1 | 3.44 |
| RP | Uehara, K.Uehara, Koji >> | 41 | 2016 | R | 48 | 33 | 0 | 0 | 0 | 3.57 | .306 | 1.30 | 9.4 | 2.4 | 9.0 | 45.1 | 47 | 18 | 18 | 3 | 12 | 45 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 2.73 |