| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 93 | 35 | 35 | 16 | 10 | 3.53 | .286 | 1.20 | 7.2 | 3.6 | 8.8 | 214.1 | 171 | 87 | 84 | 19 | 86 | 210 | 1 | 0 | 0 | 1 | 21 | 1 | 0 | 3.41 |
| SP | Strasburg, S.Strasburg, Stephen # >> | 24 | 2013 | R | 69 | 32 | 32 | 13 | 5 | 3.80 | .268 | 1.09 | 7.3 | 2.5 | 8.1 | 194.1 | 157 | 85 | 82 | 23 | 54 | 174 | 4 | 0 | 0 | 2 | 18 | 2 | 4 | 3.61 |
| SP | Martinez, P.Martinez, Pedro † >> | 26 | 1997 | R | 86 | 37 | 37 | 17 | 13 | 3.87 | .285 | 1.19 | 7.5 | 3.2 | 9.1 | 260.1 | 216 | 116 | 112 | 29 | 93 | 263 | 11 | 0 | 0 | 1 | 19 | 3 | 0 | 3.53 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 75 | 34 | 32 | 15 | 10 | 4.49 | .315 | 1.35 | 9.0 | 3.2 | 5.8 | 226.2 | 225 | 125 | 113 | 34 | 81 | 146 | 3 | 0 | 0 | 0 | 16 | 6 | 5 | 4.82 |
| RP | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 81 | 0 | 9 | 1 | 2.38 | .218 | 0.80 | 5.5 | 1.7 | 9.4 | 117.1 | 72 | 31 | 31 | 12 | 22 | 122 | 0 | 9 | 3 | 0 | 0 | 4 | 2 | 2.91 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 90 | 85 | 0 | 13 | 7 | 3.70 | .277 | 1.13 | 7.7 | 2.5 | 4.4 | 126.1 | 108 | 55 | 52 | 14 | 35 | 62 | 0 | 11 | 6 | 0 | 0 | 2 | 2 | 4.34 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 81 | 56 | 0 | 7 | 1 | 2.79 | .247 | 0.98 | 6.9 | 2.0 | 8.2 | 77.1 | 59 | 24 | 24 | 5 | 17 | 70 | 0 | 8 | 3 | 0 | 0 | 0 | 0 | 2.69 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 56 | 36 | 0 | 3 | 3 | 3.14 | .295 | 1.23 | 7.5 | 3.6 | 9.2 | 43.0 | 36 | 15 | 15 | 6 | 17 | 44 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 4.02 |
| RP | Clippard, T.Clippard, Tyler # >> | 28 | 2013 | R | 82 | 32 | 0 | 4 | 1 | 5.45 | .344 | 1.55 | 8.7 | 5.2 | 8.5 | 33.0 | 32 | 20 | 20 | 8 | 19 | 31 | 0 | 0 | 1 | 0 | 0 | 1 | 4 | 6.09 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 63 | 31 | 0 | 3 | 2 | 4.15 | .311 | 1.36 | 9.3 | 3.2 | 11.4 | 34.2 | 35 | 16 | 16 | 7 | 12 | 43 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 4.21 |
| RP | Garcia, R.Garcia, Robert >> | 27 | 2023 | L | 38 | 35 | 0 | 1 | 1 | 3.06 | .296 | 1.23 | 8.3 | 2.7 | 7.8 | 53.0 | 49 | 18 | 18 | 9 | 16 | 46 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 4.49 |
| SP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 79 | 36 | 11 | 7 | 2 | 2.78 | .282 | 1.18 | 8.4 | 2.2 | 5.6 | 94.0 | 88 | 41 | 29 | 9 | 23 | 58 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.74 |