| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 34 | 34 | 16 | 10 | 2.96 | .279 | 1.13 | 7.7 | 2.5 | 10.0 | 243.1 | 208 | 84 | 80 | 18 | 67 | 271 | 3 | 0 | 0 | 0 | 24 | 7 | 6 | 2.65 |
| SP | Crochet, G.Crochet, Garrett # >> | 26 | 2025 | L | 88 | 33 | 33 | 9 | 12 | 4.18 | .294 | 1.22 | 8.5 | 2.5 | 11.6 | 223.2 | 211 | 104 | 104 | 29 | 61 | 288 | 1 | 0 | 0 | 0 | 20 | 7 | 3 | 3.02 |
| SP | Cabrera, E.Cabrera, Edward >> | 27 | 2025 | R | 63 | 32 | 32 | 10 | 12 | 5.96 | .331 | 1.47 | 9.7 | 3.6 | 10.5 | 169.0 | 182 | 112 | 112 | 38 | 67 | 197 | 0 | 0 | 0 | 0 | 7 | 2 | 6 | 4.82 |
| SP | Singer, B.Singer, Brady >> | 28 | 2025 | R | 58 | 31 | 31 | 7 | 14 | 5.63 | .352 | 1.62 | 11.1 | 3.5 | 8.7 | 163.0 | 201 | 110 | 102 | 33 | 63 | 158 | 0 | 0 | 0 | 0 | 6 | 2 | 0 | 4.89 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 89 | 84 | 0 | 4 | 2 | 4.02 | .326 | 1.43 | 8.2 | 4.7 | 11.2 | 107.1 | 97 | 53 | 48 | 13 | 56 | 133 | 0 | 9 | 2 | 0 | 0 | 3 | 5 | 3.75 |
| RP | Kittredge, A.Kittredge, Andrew # >> | 35 | 2025 | R | 83 | 79 | 0 | 0 | 6 | 4.57 | .324 | 1.40 | 9.2 | 3.4 | 10.6 | 100.1 | 102 | 53 | 51 | 16 | 38 | 118 | 0 | 4 | 6 | 0 | 0 | 4 | 1 | 3.98 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 70 | 70 | 0 | 7 | 3 | 4.50 | .322 | 1.38 | 9.2 | 3.2 | 11.6 | 80.0 | 82 | 46 | 40 | 17 | 28 | 103 | 0 | 5 | 1 | 0 | 0 | 4 | 2 | 4.39 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 69 | 56 | 0 | 5 | 7 | 5.55 | .373 | 1.75 | 12.4 | 3.4 | 7.6 | 58.1 | 80 | 37 | 36 | 13 | 22 | 49 | 0 | 8 | 5 | 0 | 0 | 2 | 0 | 5.47 |
| RP | Stewart, B.Stewart, Brock >> | 33 | 2025 | R | 54 | 39 | 0 | 2 | 3 | 5.09 | .292 | 1.24 | 8.0 | 3.1 | 11.3 | 46.0 | 41 | 26 | 26 | 9 | 16 | 58 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 4.07 |
| RP | Gaddis, H.Gaddis, Hunter >> | 27 | 2025 | R | 53 | 41 | 0 | 2 | 1 | 3.02 | .296 | 1.26 | 9.2 | 2.3 | 8.6 | 50.2 | 51 | 17 | 17 | 7 | 13 | 48 | 0 | 1 | 3 | 0 | 0 | 0 | 2 | 3.68 |