| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 9 | 9 | 3 | 3 | 2.35 | .261 | 1.00 | 6.8 | 2.2 | 10.7 | 65.0 | 49 | 18 | 17 | 4 | 16 | 77 | 2 | 0 | 0 | 0 | 8 | 4 | 2 | 2.35 |
| SP | Crochet, G.Crochet, Garrett # >> | 26 | 2025 | L | 88 | 9 | 9 | 2 | 2 | 4.02 | .261 | 1.00 | 6.5 | 2.5 | 12.2 | 65.0 | 47 | 29 | 29 | 10 | 18 | 88 | 1 | 0 | 0 | 0 | 6 | 4 | 1 | 3.31 |
| SP | Cabrera, E.Cabrera, Edward >> | 27 | 2025 | R | 63 | 9 | 9 | 2 | 3 | 5.93 | .337 | 1.50 | 9.4 | 4.1 | 10.8 | 44.0 | 46 | 29 | 29 | 8 | 20 | 53 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 4.39 |
| SP | Singer, B.Singer, Brady >> | 28 | 2025 | R | 58 | 8 | 8 | 2 | 3 | 6.18 | .372 | 1.78 | 11.3 | 4.8 | 9.9 | 39.1 | 49 | 29 | 27 | 10 | 21 | 43 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5.74 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 89 | 24 | 0 | 3 | 1 | 2.90 | .316 | 1.35 | 8.7 | 3.5 | 11.3 | 31.0 | 30 | 10 | 10 | 4 | 12 | 39 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 3.42 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 83 | 20 | 0 | 0 | 2 | 6.17 | .352 | 1.54 | 11.7 | 2.3 | 10.2 | 23.1 | 30 | 16 | 16 | 5 | 6 | 26 | 0 | 2 | 4 | 0 | 0 | 2 | 1 | 4.61 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 70 | 16 | 0 | 1 | 1 | 7.50 | .365 | 1.61 | 11.0 | 3.5 | 12.5 | 18.0 | 22 | 15 | 15 | 6 | 7 | 25 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 6.06 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 69 | 14 | 0 | 1 | 1 | 3.94 | .342 | 1.50 | 10.7 | 2.8 | 9.0 | 16.0 | 19 | 7 | 7 | 1 | 5 | 16 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 2.94 |
| RP | Stewart, B.Stewart, Brock >> | 33 | 2025 | R | 54 | 11 | 0 | 0 | 1 | 6.59 | .359 | 1.68 | 10.4 | 5.5 | 15.2 | 13.2 | 15 | 10 | 10 | 4 | 8 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5.46 |
| RP | Gaddis, H.Gaddis, Hunter >> | 27 | 2025 | R | 53 | 14 | 0 | 2 | 0 | 2.08 | .325 | 1.44 | 10.1 | 3.2 | 13.2 | 17.1 | 19 | 4 | 4 | 3 | 6 | 25 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.41 |