| SP | Jimenez, U.Jimenez, Ubaldo # >> | 26 | 2010 | R | 60 | 16 | 16 | 5 | 6 | 5.18 | .327 | 1.43 | 9.7 | 3.2 | 7.6 | 99.0 | 107 | 59 | 57 | 9 | 35 | 84 | 1 | 0 | 0 | 0 | 6 | 2 | 4 | 3.61 |
| SP | Chacin, J.Chacin, Jhoulys >> | 22 | 2010 | R | 45 | 16 | 16 | 5 | 5 | 6.57 | .378 | 1.78 | 10.0 | 6.1 | 8.8 | 74.0 | 82 | 58 | 54 | 8 | 50 | 72 | 0 | 0 | 0 | 0 | 1 | 3 | 2 | 4.61 |
| SP | Thomson, J.Thomson, John >> | 28 | 2001 | R | 47 | 16 | 16 | 0 | 1 | 4.01 | .281 | 1.15 | 8.6 | 1.9 | 6.0 | 42.2 | 40 | 19 | 19 | 4 | 9 | 28 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.62 |
| SP | Marquez, G.Marquez, German >> | 26 | 2021 | R | 40 | 15 | 15 | 1 | 5 | 4.87 | .345 | 1.58 | 9.8 | 4.5 | 7.5 | 64.2 | 70 | 35 | 35 | 10 | 32 | 53 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.88 |
| RP | Ottavino, A.Ottavino, Adam >> | 32 | 2018 | R | 69 | 41 | 0 | 4 | 1 | 3.52 | .300 | 1.25 | 6.1 | 5.3 | 10.4 | 53.2 | 36 | 21 | 21 | 6 | 31 | 61 | 0 | 1 | 2 | 0 | 0 | 2 | 5 | 4.04 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 65 | 36 | 0 | 4 | 2 | 4.46 | .345 | 1.56 | 9.0 | 5.1 | 8.6 | 42.1 | 42 | 23 | 21 | 3 | 24 | 40 | 0 | 3 | 1 | 0 | 0 | 1 | 3 | 3.81 |
| RP | Buchholz, T.Buchholz, Taylor >> | 27 | 2008 | R | 57 | 33 | 0 | 1 | 2 | 4.78 | .297 | 1.22 | 7.5 | 3.6 | 7.1 | 43.1 | 36 | 23 | 23 | 7 | 17 | 34 | 0 | 6 | 2 | 0 | 0 | 2 | 0 | 4.86 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 66 | 28 | 0 | 3 | 0 | 4.59 | .301 | 1.20 | 9.0 | 1.9 | 10.6 | 33.1 | 33 | 17 | 17 | 5 | 7 | 39 | 0 | 4 | 4 | 0 | 0 | 3 | 0 | 3.52 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 67 | 22 | 0 | 0 | 0 | 1.19 | .157 | 0.56 | 4.5 | 0.6 | 10.2 | 30.1 | 15 | 4 | 4 | 0 | 2 | 34 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 0.93 |
| RP | Herges, M.Herges, Matt >> | 37 | 2007 | R | 46 | 20 | 0 | 1 | 2 | 3.64 | .299 | 1.28 | 8.1 | 3.7 | 6.2 | 29.2 | 26 | 12 | 12 | 3 | 12 | 20 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.21 |
| SP | De La Rosa, J.De La Rosa, Jorge >> | 30 | 2011 | L | 50 | 32 | 0 | 14 | 0 | 5.05 | .309 | 1.29 | 8.3 | 3.3 | 5.0 | 82.0 | 76 | 46 | 46 | 14 | 30 | 46 | 0 | 0 | 0 | 0 | 0 | 4 | 5 | 5.34 |