| SP | Scherzer, M.Scherzer, Max >> | 38 | 2022 | R | 92 | 31 | 31 | 12 | 8 | 3.79 | .299 | 1.27 | 8.6 | 2.9 | 8.5 | 202.0 | 192 | 88 | 85 | 17 | 64 | 191 | 1 | 0 | 0 | 1 | 18 | 2 | 3 | 3.18 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 86 | 31 | 31 | 11 | 11 | 3.50 | .304 | 1.29 | 9.3 | 2.3 | 8.5 | 203.1 | 209 | 81 | 79 | 12 | 53 | 191 | 3 | 0 | 0 | 1 | 19 | 5 | 1 | 2.74 |
| SP | Fernandez, S.Fernandez, Sid † >> | 31 | 1993 | L | 77 | 32 | 32 | 15 | 13 | 3.45 | .301 | 1.26 | 7.5 | 3.8 | 4.9 | 211.0 | 176 | 87 | 81 | 9 | 90 | 114 | 3 | 0 | 0 | 0 | 20 | 7 | 2 | 3.85 |
| SP | Syndergaard, N.Syndergaard, Noah # >> | 22 | 2015 | R | 64 | 31 | 31 | 7 | 15 | 5.63 | .327 | 1.44 | 10.1 | 2.9 | 7.7 | 161.1 | 180 | 112 | 101 | 22 | 52 | 138 | 2 | 0 | 0 | 0 | 14 | 3 | 4 | 4.09 |
| CL | deGrom, J.deGrom, Jacob >> | 34 | 2022 | R | 90 | 55 | 0 | 3 | 5 | 4.50 | .306 | 1.29 | 8.8 | 2.7 | 9.0 | 56.0 | 55 | 29 | 28 | 5 | 17 | 56 | 0 | 36 | 9 | 0 | 0 | 2 | 0 | 3.18 |
| RP | Verrett, L.Verrett, Logan >> | 25 | 2015 | R | 76 | 61 | 0 | 5 | 1 | 4.49 | .305 | 1.28 | 7.3 | 4.3 | 5.5 | 122.1 | 99 | 61 | 61 | 22 | 58 | 74 | 0 | 2 | 1 | 0 | 0 | 4 | 0 | 5.66 |
| RP | Wagner, B.Wagner, Billy >> | 37 | 2008 | L | 74 | 48 | 0 | 4 | 1 | 2.82 | .254 | 1.01 | 6.2 | 3.0 | 7.7 | 60.2 | 41 | 19 | 19 | 8 | 20 | 51 | 0 | 0 | 2 | 0 | 0 | 1 | 2 | 4.08 |
| RP | Carlyle, B.Carlyle, Buddy >> | 37 | 2014 | R | 63 | 40 | 0 | 2 | 4 | 4.17 | .306 | 1.30 | 9.4 | 2.4 | 5.8 | 45.1 | 47 | 22 | 21 | 6 | 12 | 29 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.31 |
| RP | Manzanillo, J.Manzanillo, Josias >> | 27 | 1994 | R | 56 | 31 | 0 | 2 | 0 | 3.00 | .240 | 0.92 | 6.9 | 1.4 | 6.2 | 39.0 | 30 | 13 | 13 | 5 | 6 | 27 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.82 |