| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 100 | 16 | 16 | 6 | 7 | 3.47 | .304 | 1.30 | 8.5 | 3.3 | 6.5 | 124.2 | 117 | 50 | 48 | 9 | 45 | 89 | 4 | 0 | 0 | 0 | 9 | 1 | 3 | 3.62 |
| SP | Valenzuela, F.Valenzuela, Fernando >> | 22 | 1982 | L | 85 | 16 | 16 | 3 | 11 | 6.84 | .363 | 1.68 | 11.7 | 3.5 | 5.6 | 101.1 | 131 | 79 | 77 | 16 | 39 | 63 | 3 | 0 | 0 | 0 | 3 | 3 | 0 | 5.06 |
| SP | Langston, M.Langston, Mark >> | 28 | 1988 | L | 77 | 16 | 16 | 5 | 7 | 5.37 | .348 | 1.60 | 9.4 | 5.0 | 7.1 | 107.1 | 112 | 69 | 64 | 14 | 60 | 84 | 2 | 0 | 0 | 1 | 5 | 0 | 2 | 4.81 |
| SP | Torrez, M.Torrez, Mike >> | 26 | 1972 | R | 48 | 15 | 15 | 6 | 6 | 5.04 | .336 | 1.52 | 10.2 | 3.5 | 4.2 | 100.0 | 113 | 60 | 56 | 18 | 39 | 47 | 4 | 0 | 0 | 1 | 6 | 0 | 1 | 5.57 |
| RP | Bednar, D.Bednar, David >> | 26 | 2021 | R | 95 | 46 | 0 | 0 | 1 | 4.68 | .314 | 1.35 | 7.7 | 4.5 | 11.4 | 42.1 | 36 | 24 | 22 | 3 | 21 | 53 | 0 | 5 | 2 | 0 | 0 | 1 | 2 | 2.98 |
| RP | Scheppers, T.Scheppers, Tanner >> | 26 | 2013 | R | 79 | 32 | 0 | 3 | 3 | 5.26 | .323 | 1.43 | 9.2 | 3.9 | 5.1 | 37.2 | 38 | 22 | 22 | 5 | 16 | 21 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 4.92 |
| RP | Boxberger, B.Boxberger, Brad >> | 27 | 2015 | R | 48 | 15 | 0 | 3 | 1 | 4.80 | .338 | 1.53 | 10.2 | 3.6 | 6.0 | 15.0 | 17 | 9 | 8 | 3 | 6 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.47 |
| RP | Breslow, C.Breslow, Craig >> | 29 | 2009 | L | 81 | 42 | 0 | 1 | 0 | 4.22 | .338 | 1.50 | 8.7 | 4.8 | 7.6 | 32.0 | 31 | 16 | 15 | 4 | 17 | 27 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 4.63 |