| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 9 | 9 | 2 | 2 | 2.72 | .246 | 0.98 | 6.1 | 2.7 | 10.4 | 53.0 | 36 | 16 | 16 | 9 | 16 | 61 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 3.81 |
| SP | Gilbert, L.Gilbert, Logan >> | 28 | 2025 | R | 89 | 9 | 9 | 3 | 3 | 4.75 | .304 | 1.23 | 7.7 | 3.4 | 11.7 | 47.1 | 40 | 25 | 25 | 7 | 18 | 61 | 0 | 0 | 0 | 0 | 4 | 4 | 1 | 3.74 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 77 | 9 | 9 | 5 | 2 | 4.11 | .335 | 1.51 | 9.2 | 4.5 | 7.7 | 50.1 | 51 | 24 | 23 | 6 | 25 | 43 | 0 | 0 | 0 | 0 | 4 | 0 | 3 | 4.34 |
| SP | Imanaga, S.Imanaga, Shota >> | 31 | 2025 | L | 80 | 8 | 7 | 5 | 1 | 2.87 | .242 | 0.94 | 6.5 | 1.9 | 7.7 | 47.0 | 34 | 16 | 15 | 2 | 10 | 40 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 2.55 |
| CL | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 22 | 0 | 4 | 1 | 3.38 | .250 | 0.96 | 6.4 | 2.3 | 12.0 | 24.0 | 17 | 9 | 9 | 2 | 6 | 32 | 0 | 10 | 3 | 0 | 0 | 1 | 3 | 2.29 |
| SU | Keller, B.Keller, Brad >> | 29 | 2025 | R | 89 | 22 | 0 | 1 | 0 | 6.88 | .414 | 2.00 | 11.6 | 6.4 | 11.1 | 17.0 | 22 | 13 | 13 | 5 | 12 | 21 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 6.82 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 81 | 20 | 0 | 2 | 1 | 1.65 | .268 | 1.10 | 6.3 | 3.7 | 8.7 | 27.1 | 19 | 5 | 5 | 4 | 11 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.22 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 77 | 20 | 0 | 0 | 1 | 6.10 | .326 | 1.40 | 9.5 | 3.6 | 12.2 | 20.2 | 21 | 14 | 14 | 6 | 8 | 27 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.55 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 71 | 12 | 0 | 0 | 0 | 3.06 | .254 | 1.02 | 6.9 | 2.6 | 9.0 | 17.2 | 13 | 6 | 6 | 2 | 5 | 17 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.41 |
| SP | Singer, B.Singer, Brady >> | 28 | 2025 | R | 58 | 9 | 1 | 3 | 2 | 5.40 | .336 | 1.52 | 11.5 | 2.2 | 10.4 | 25.0 | 32 | 15 | 15 | 6 | 6 | 29 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.52 |