| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 11 | 11 | 3 | 3 | 5.20 | .307 | 1.33 | 10.0 | 2.0 | 8.0 | 62.1 | 69 | 37 | 36 | 8 | 14 | 55 | 1 | 0 | 0 | 1 | 5 | 0 | 3 | 3.58 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 81 | 12 | 11 | 2 | 7 | 6.34 | .335 | 1.49 | 9.9 | 3.7 | 8.4 | 59.2 | 65 | 43 | 42 | 13 | 24 | 55 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 5.27 |
| SP | Bello, B.Bello, Brayan >> | 26 | 2025 | R | 53 | 11 | 11 | 3 | 4 | 4.50 | .305 | 1.30 | 9.0 | 2.7 | 6.5 | 60.0 | 60 | 31 | 30 | 13 | 18 | 43 | 0 | 0 | 0 | 0 | 6 | 1 | 2 | 5.33 |
| SU | Rodríguez, R.Rodríguez, Randy >> | 25 | 2025 | R | 95 | 40 | 0 | 1 | 0 | 2.40 | .288 | 1.19 | 9.2 | 1.7 | 9.4 | 48.2 | 49 | 13 | 13 | 5 | 9 | 50 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 2.90 |
| CL | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 88 | 27 | 0 | 2 | 4 | 5.08 | .282 | 1.13 | 7.6 | 2.5 | 11.8 | 39.0 | 33 | 22 | 22 | 4 | 11 | 51 | 0 | 5 | 2 | 0 | 0 | 2 | 0 | 2.72 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 67 | 37 | 0 | 6 | 5 | 7.65 | .365 | 1.70 | 10.4 | 5.0 | 7.7 | 40.0 | 46 | 35 | 34 | 11 | 22 | 34 | 0 | 0 | 3 | 0 | 0 | 1 | 1 | 6.60 |
| RP | Fairbanks, P.Fairbanks, Peter >> | 31 | 2025 | R | 72 | 28 | 0 | 0 | 1 | 5.86 | .362 | 1.70 | 11.0 | 4.7 | 7.0 | 27.2 | 33 | 19 | 18 | 4 | 14 | 21 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 4.93 |