| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 20 | 20 | 8 | 10 | 3.07 | .271 | 1.09 | 7.8 | 2.1 | 11.2 | 140.2 | 121 | 54 | 48 | 11 | 32 | 174 | 2 | 0 | 0 | 1 | 15 | 4 | 1 | 2.31 |
| SP | Gilbert, L.Gilbert, Logan >> | 28 | 2025 | R | 89 | 19 | 19 | 4 | 10 | 5.38 | .333 | 1.47 | 9.7 | 3.5 | 12.4 | 100.1 | 108 | 62 | 60 | 14 | 39 | 138 | 0 | 0 | 0 | 0 | 5 | 3 | 6 | 3.32 |
| SP | Sanchez, C.Sanchez, Cristopher >> | 28 | 2025 | L | 79 | 19 | 19 | 6 | 10 | 4.19 | .289 | 1.21 | 8.7 | 2.2 | 9.6 | 129.0 | 125 | 64 | 60 | 19 | 31 | 138 | 0 | 0 | 0 | 0 | 10 | 1 | 1 | 3.52 |
| SP | Williams, G.Williams, Gavin >> | 25 | 2025 | R | 64 | 19 | 19 | 9 | 5 | 4.12 | .327 | 1.40 | 8.1 | 4.5 | 10.9 | 107.0 | 96 | 53 | 49 | 17 | 54 | 130 | 0 | 0 | 0 | 0 | 8 | 6 | 1 | 4.32 |
| SP | Flaherty, J.Flaherty, Jack >> | 29 | 2025 | R | 52 | 19 | 19 | 6 | 10 | 6.51 | .372 | 1.76 | 11.3 | 4.6 | 11.0 | 92.2 | 116 | 72 | 67 | 19 | 47 | 112 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.85 |
| RP | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 86 | 50 | 0 | 1 | 1 | 1.90 | .242 | 0.94 | 4.9 | 3.5 | 10.5 | 71.0 | 39 | 17 | 15 | 5 | 28 | 83 | 0 | 7 | 3 | 0 | 0 | 1 | 0 | 2.80 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 71 | 38 | 0 | 1 | 0 | 2.79 | .272 | 1.10 | 6.4 | 3.4 | 10.7 | 42.0 | 30 | 13 | 13 | 5 | 16 | 50 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 3.38 |
| RP | Estrada, J.Estrada, Jeremiah >> | 26 | 2025 | R | 63 | 31 | 0 | 1 | 0 | 7.33 | .430 | 2.26 | 11.3 | 9.0 | 10.7 | 27.0 | 34 | 22 | 22 | 5 | 27 | 32 | 0 | 3 | 1 | 0 | 0 | 0 | 3 | 6.04 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 61 | 13 | 0 | 2 | 1 | 4.82 | .356 | 1.55 | 9.5 | 5.0 | 7.5 | 18.2 | 19 | 11 | 10 | 1 | 10 | 15 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 4.06 |