| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 38 | 38 | 14 | 12 | 3.65 | .293 | 1.22 | 9.0 | 2.0 | 9.9 | 237.0 | 236 | 100 | 96 | 30 | 52 | 261 | 2 | 0 | 0 | 0 | 26 | 6 | 3 | 3.18 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 77 | 34 | 34 | 10 | 16 | 5.60 | .337 | 1.51 | 9.5 | 4.1 | 7.9 | 173.2 | 183 | 109 | 108 | 33 | 79 | 151 | 0 | 0 | 0 | 0 | 12 | 3 | 5 | 5.16 |
| SP | Littell, Z.Littell, Zack # >> | 29 | 2025 | R | 59 | 35 | 34 | 11 | 5 | 4.93 | .324 | 1.41 | 10.1 | 2.7 | 7.3 | 180.2 | 201 | 101 | 99 | 25 | 53 | 146 | 0 | 0 | 0 | 0 | 17 | 6 | 3 | 4.17 |
| RP | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 90 | 93 | 0 | 6 | 7 | 2.96 | .292 | 1.19 | 7.7 | 3.0 | 9.1 | 124.2 | 106 | 46 | 41 | 9 | 42 | 126 | 0 | 1 | 3 | 0 | 0 | 6 | 1 | 3.07 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 90 | 0 | 8 | 2 | 2.90 | .274 | 1.09 | 6.2 | 3.6 | 8.4 | 115.0 | 79 | 39 | 37 | 12 | 46 | 107 | 0 | 2 | 5 | 0 | 0 | 5 | 0 | 3.83 |
| RP | Bazardo, E.Bazardo, Eduard >> | 29 | 2025 | R | 85 | 77 | 0 | 10 | 4 | 5.02 | .314 | 1.35 | 8.3 | 4.0 | 9.8 | 84.1 | 77 | 48 | 47 | 19 | 37 | 91 | 0 | 3 | 2 | 0 | 0 | 2 | 2 | 5.17 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 82 | 60 | 0 | 2 | 1 | 3.52 | .302 | 1.27 | 7.9 | 3.5 | 6.6 | 64.0 | 56 | 26 | 25 | 2 | 25 | 47 | 0 | 2 | 2 | 0 | 0 | 2 | 4 | 3.20 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 71 | 36 | 0 | 1 | 1 | 5.00 | .325 | 1.39 | 8.3 | 4.3 | 7.8 | 36.0 | 33 | 22 | 20 | 8 | 17 | 31 | 0 | 3 | 1 | 0 | 0 | 2 | 2 | 5.75 |
| RP | Estrada, J.Estrada, Jeremiah >> | 26 | 2025 | R | 63 | 44 | 0 | 1 | 0 | 2.61 | .276 | 1.08 | 6.9 | 3.0 | 12.7 | 51.2 | 39 | 15 | 15 | 5 | 17 | 72 | 0 | 2 | 0 | 0 | 0 | 3 | 1 | 2.63 |
| CL | Speier, G.Speier, Gabe † >> | 30 | 2025 | L | 96 | 71 | 0 | 4 | 12 | 3.50 | .253 | 1.02 | 7.7 | 1.6 | 11.4 | 74.2 | 63 | 29 | 29 | 7 | 13 | 94 | 0 | 35 | 3 | 0 | 0 | 0 | 1 | 2.22 |