| SP | Jimenez, U.Jimenez, Ubaldo >> | 26 | 2010 | R | 89 | 28 | 28 | 11 | 11 | 4.38 | .305 | 1.30 | 8.0 | 3.7 | 7.2 | 189.0 | 169 | 96 | 92 | 22 | 77 | 151 | 1 | 0 | 0 | 0 | 15 | 3 | 10 | 4.19 |
| SP | Morales, F.Morales, Franklin >> | 24 | 2007 | L | 72 | 27 | 27 | 11 | 9 | 3.73 | .297 | 1.25 | 8.4 | 2.9 | 5.4 | 161.2 | 151 | 71 | 67 | 23 | 51 | 96 | 0 | 0 | 0 | 0 | 16 | 3 | 0 | 4.67 |
| SP | Chacin, J.Chacin, Jhoulys >> | 22 | 2010 | R | 66 | 27 | 27 | 9 | 8 | 3.76 | .322 | 1.40 | 8.9 | 3.7 | 8.9 | 138.2 | 137 | 64 | 58 | 15 | 57 | 137 | 0 | 0 | 0 | 0 | 4 | 4 | 4 | 3.75 |
| SP | Francis, J.Francis, Jeff # >> | 29 | 2006 | L | 59 | 27 | 27 | 12 | 9 | 4.95 | .319 | 1.37 | 9.1 | 3.3 | 6.2 | 174.2 | 176 | 97 | 96 | 27 | 64 | 120 | 3 | 0 | 0 | 2 | 13 | 6 | 0 | 4.84 |
| RP | Buchholz, T.Buchholz, Taylor >> | 29 | 2008 | R | 83 | 78 | 0 | 4 | 2 | 3.49 | .276 | 1.14 | 7.2 | 3.1 | 7.0 | 85.0 | 68 | 33 | 33 | 8 | 29 | 66 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 3.69 |
| RP | Betancourt, R.Betancourt, Rafael >> | 35 | 2010 | R | 82 | 69 | 0 | 2 | 3 | 3.93 | .297 | 1.22 | 8.5 | 2.6 | 10.3 | 68.2 | 64 | 30 | 30 | 9 | 20 | 78 | 0 | 3 | 4 | 0 | 0 | 3 | 4 | 3.44 |
| RP | Ramirez, R.Ramirez, Ramon >> | 29 | 2006 | R | 77 | 50 | 0 | 3 | 1 | 2.17 | .290 | 1.21 | 7.5 | 3.5 | 7.2 | 49.2 | 41 | 13 | 12 | 3 | 19 | 39 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 3.43 |
| RP | Corpas, M.Corpas, Manuel >> | 28 | 2007 | R | 75 | 38 | 0 | 3 | 2 | 6.29 | .340 | 1.54 | 11.1 | 2.9 | 7.7 | 34.1 | 42 | 24 | 24 | 7 | 11 | 29 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.94 |
| RP | Affeldt, J.Affeldt, Jeremy >> | 31 | 2009 | L | 67 | 84 | 0 | 1 | 1 | 6.75 | .354 | 1.64 | 8.5 | 6.3 | 8.4 | 56.0 | 53 | 42 | 42 | 7 | 39 | 52 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 4.86 |
| SP | De La Rosa, J.De La Rosa, Jorge >> | 29 | 2008 | L | 51 | 23 | 0 | 2 | 2 | 9.55 | .418 | 2.15 | 13.4 | 6.2 | 7.4 | 60.1 | 89 | 65 | 64 | 13 | 41 | 49 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 6.23 |
| CL | Street, H.Street, Huston >> | 27 | 2009 | R | 94 | 48 | 0 | 2 | 8 | 4.73 | .325 | 1.40 | 9.5 | 3.2 | 8.8 | 51.1 | 54 | 27 | 27 | 9 | 18 | 50 | 0 | 22 | 6 | 0 | 0 | 2 | 0 | 4.51 |