| SP | Jimenez, U.Jimenez, Ubaldo # >> | 27 | 2010 | R | 77 | 35 | 35 | 11 | 14 | 4.98 | .298 | 1.26 | 8.5 | 2.8 | 8.4 | 231.1 | 219 | 130 | 128 | 35 | 73 | 215 | 2 | 0 | 0 | 2 | 17 | 3 | 9 | 4.10 |
| SP | Morales, F.Morales, Franklin >> | 25 | 2007 | L | 71 | 35 | 35 | 11 | 8 | 4.15 | .307 | 1.30 | 8.9 | 2.8 | 7.7 | 210.1 | 208 | 97 | 97 | 26 | 66 | 179 | 1 | 0 | 0 | 0 | 19 | 5 | 0 | 3.92 |
| SP | De La Rosa, J.De La Rosa, Jorge >> | 30 | 2008 | L | 58 | 32 | 32 | 8 | 15 | 6.05 | .344 | 1.55 | 10.8 | 3.1 | 7.7 | 174.0 | 209 | 122 | 117 | 27 | 60 | 148 | 0 | 0 | 0 | 0 | 9 | 5 | 10 | 4.44 |
| SP | Chacin, J.Chacin, Jhoulys >> | 23 | 2010 | R | 53 | 32 | 32 | 11 | 9 | 5.15 | .337 | 1.49 | 8.9 | 4.6 | 8.4 | 160.2 | 159 | 93 | 92 | 27 | 81 | 150 | 0 | 0 | 0 | 0 | 4 | 5 | 5 | 4.93 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 90 | 103 | 0 | 8 | 7 | 4.44 | .327 | 1.42 | 10.5 | 2.3 | 9.2 | 101.1 | 118 | 51 | 50 | 9 | 26 | 103 | 0 | 1 | 8 | 0 | 0 | 4 | 5 | 3.01 |
| RP | Buchholz, T.Buchholz, Taylor >> | 30 | 2008 | R | 86 | 86 | 0 | 6 | 2 | 3.08 | .283 | 1.17 | 7.8 | 2.9 | 7.7 | 87.2 | 75 | 30 | 30 | 5 | 28 | 74 | 0 | 2 | 2 | 0 | 0 | 1 | 4 | 3.05 |
| RP | Ramirez, R.Ramirez, Ramon >> | 30 | 2006 | R | 67 | 58 | 0 | 6 | 2 | 6.06 | .361 | 1.69 | 12.7 | 2.6 | 8.1 | 49.0 | 69 | 34 | 33 | 9 | 14 | 44 | 0 | 1 | 4 | 0 | 0 | 0 | 1 | 4.45 |
| RP | Affeldt, J.Affeldt, Jeremy # >> | 32 | 2009 | L | 56 | 111 | 0 | 3 | 1 | 4.61 | .306 | 1.33 | 8.4 | 3.5 | 8.2 | 80.0 | 75 | 42 | 41 | 12 | 31 | 73 | 0 | 1 | 3 | 0 | 0 | 0 | 2 | 4.29 |
| RP | Corpas, M.Corpas, Manuel >> | 29 | 2007 | R | 53 | 42 | 0 | 2 | 2 | 6.75 | .367 | 1.74 | 12.9 | 2.9 | 8.0 | 37.1 | 53 | 29 | 28 | 3 | 12 | 33 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.24 |
| CL | Street, H.Street, Huston >> | 28 | 2009 | R | 95 | 62 | 0 | 4 | 11 | 4.59 | .336 | 1.50 | 10.1 | 3.5 | 11.3 | 64.2 | 72 | 36 | 33 | 3 | 25 | 80 | 0 | 34 | 4 | 0 | 0 | 1 | 0 | 2.33 |
| SP | Francis, J.Francis, Jeff >> | 30 | 2006 | L | 48 | 29 | 0 | 2 | 0 | 7.47 | .358 | 1.63 | 12.1 | 2.6 | 7.1 | 90.1 | 121 | 75 | 75 | 17 | 26 | 71 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 4.88 |