| SP | Skubal, T.Skubal, Tarik $$ >> | 28 | 2025 | L | 100 | 36 | 36 | 16 | 10 | 2.73 | .251 | 0.98 | 6.8 | 2.1 | 11.1 | 247.1 | 186 | 77 | 75 | 20 | 57 | 304 | 5 | 0 | 0 | 3 | 26 | 6 | 3 | 2.36 |
| SP | Gausman, K.Gausman, Kevin † $$ >> | 34 | 2025 | R | 82 | 34 | 34 | 16 | 11 | 4.21 | .316 | 1.36 | 9.1 | 3.1 | 8.6 | 207.1 | 209 | 98 | 97 | 19 | 72 | 198 | 1 | 0 | 0 | 0 | 18 | 6 | 1 | 3.41 |
| SP | Kirby, G.Kirby, George # >> | 27 | 2025 | R | 61 | 33 | 33 | 8 | 13 | 4.91 | .335 | 1.49 | 10.9 | 2.5 | 10.4 | 174.0 | 211 | 98 | 95 | 20 | 49 | 201 | 0 | 0 | 0 | 0 | 10 | 3 | 4 | 3.08 |
| SP | Bibee, T.Bibee, Tanner # >> | 26 | 2025 | R | 54 | 32 | 31 | 12 | 15 | 4.45 | .323 | 1.39 | 10.0 | 2.5 | 8.1 | 184.0 | 204 | 94 | 91 | 22 | 51 | 166 | 0 | 0 | 0 | 0 | 14 | 8 | 2 | 3.71 |
| RP | Rodríguez, R.Rodríguez, Randy >> | 25 | 2025 | R | 95 | 101 | 0 | 4 | 5 | 3.37 | .278 | 1.10 | 6.5 | 3.5 | 10.2 | 120.1 | 86 | 48 | 45 | 10 | 46 | 136 | 0 | 7 | 4 | 0 | 0 | 7 | 3 | 3.14 |
| RP | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 90 | 96 | 0 | 7 | 5 | 4.45 | .328 | 1.42 | 7.9 | 4.9 | 10.1 | 95.0 | 83 | 48 | 47 | 5 | 52 | 107 | 0 | 9 | 4 | 0 | 0 | 4 | 12 | 3.20 |
| RP | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 80 | 73 | 0 | 6 | 2 | 4.58 | .339 | 1.53 | 10.8 | 3.0 | 8.9 | 74.2 | 89 | 38 | 38 | 9 | 25 | 73 | 0 | 9 | 2 | 0 | 0 | 1 | 0 | 3.66 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 70 | 60 | 0 | 4 | 1 | 3.77 | .332 | 1.47 | 9.8 | 3.7 | 8.5 | 59.2 | 64 | 30 | 25 | 5 | 24 | 56 | 0 | 6 | 1 | 0 | 0 | 1 | 3 | 3.47 |
| RP | Gibson, C.Gibson, Cade $$ >> | 27 | 2025 | L | 49 | 114 | 0 | 2 | 5 | 2.37 | .267 | 1.07 | 6.5 | 3.1 | 9.2 | 106.1 | 77 | 32 | 28 | 8 | 37 | 108 | 0 | 11 | 2 | 0 | 0 | 2 | 8 | 3.05 |
| SP | Bassitt, C.Bassitt, Chris >> | 36 | 2025 | R | 26 | 31 | 0 | 2 | 6 | 5.61 | .356 | 1.62 | 10.7 | 4.0 | 8.4 | 43.1 | 51 | 30 | 27 | 7 | 19 | 40 | 0 | 5 | 1 | 0 | 0 | 2 | 0 | 4.72 |