| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 28 | 28 | 15 | 5 | 2.54 | .256 | 0.99 | 7.1 | 1.8 | 11.0 | 202.0 | 159 | 59 | 57 | 20 | 40 | 248 | 1 | 0 | 0 | 0 | 23 | 9 | 1 | 2.56 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 82 | 27 | 27 | 9 | 13 | 6.52 | .358 | 1.63 | 10.7 | 4.0 | 9.2 | 146.1 | 174 | 109 | 106 | 33 | 65 | 149 | 0 | 0 | 0 | 0 | 7 | 6 | 3 | 5.36 |
| SP | Pepiot, R.Pepiot, Ryan >> | 27 | 2025 | R | 78 | 27 | 26 | 6 | 7 | 4.45 | .343 | 1.53 | 8.6 | 5.3 | 10.3 | 141.2 | 134 | 71 | 70 | 16 | 83 | 162 | 0 | 0 | 0 | 0 | 8 | 5 | 4 | 4.05 |
| SP | Williams, G.Williams, Gavin >> | 25 | 2025 | R | 65 | 27 | 26 | 7 | 11 | 4.94 | .355 | 1.60 | 9.0 | 5.5 | 9.6 | 140.1 | 140 | 90 | 77 | 25 | 85 | 149 | 0 | 0 | 1 | 0 | 9 | 7 | 5 | 5.16 |
| SP | Kershaw, C.Kershaw, Clayton >> | 37 | 2025 | L | 57 | 29 | 26 | 9 | 8 | 5.17 | .348 | 1.56 | 10.4 | 3.7 | 8.0 | 125.1 | 144 | 76 | 72 | 16 | 51 | 111 | 0 | 0 | 0 | 0 | 3 | 6 | 6 | 4.26 |
| RP | Speier, G.Speier, Gabe >> | 30 | 2025 | L | 96 | 100 | 0 | 10 | 4 | 3.05 | .260 | 1.03 | 6.6 | 2.7 | 11.5 | 100.1 | 73 | 35 | 34 | 5 | 30 | 128 | 0 | 4 | 3 | 0 | 0 | 3 | 1 | 2.08 |
| RP | Bazardo, E.Bazardo, Eduard >> | 29 | 2025 | R | 87 | 94 | 0 | 4 | 5 | 4.25 | .324 | 1.36 | 7.9 | 4.4 | 11.8 | 84.2 | 74 | 40 | 40 | 13 | 41 | 110 | 0 | 2 | 3 | 0 | 0 | 7 | 1 | 4.11 |
| RP | Sousa, B.Sousa, Bennett >> | 30 | 2025 | L | 82 | 84 | 0 | 2 | 4 | 4.72 | .308 | 1.31 | 9.1 | 2.8 | 11.9 | 87.2 | 88 | 47 | 46 | 14 | 27 | 115 | 0 | 9 | 3 | 0 | 0 | 2 | 3 | 3.45 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 73 | 78 | 0 | 6 | 2 | 4.01 | .327 | 1.41 | 7.8 | 4.9 | 10.2 | 83.0 | 72 | 38 | 37 | 9 | 45 | 94 | 0 | 4 | 2 | 0 | 0 | 4 | 4 | 3.92 |
| RP | Holton, T.Holton, Tyler >> | 29 | 2025 | L | 63 | 65 | 0 | 4 | 2 | 4.36 | .326 | 1.41 | 10.1 | 2.7 | 7.5 | 74.1 | 83 | 42 | 36 | 12 | 22 | 62 | 0 | 11 | 1 | 0 | 0 | 3 | 1 | 4.45 |