| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 6 | 6 | 2 | 2 | 2.30 | .271 | 1.09 | 8.2 | 1.7 | 9.2 | 43.0 | 39 | 13 | 11 | 1 | 8 | 44 | 1 | 0 | 0 | 0 | 5 | 1 | 1 | 1.88 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 82 | 6 | 6 | 5 | 1 | 3.82 | .339 | 1.49 | 9.5 | 4.1 | 9.7 | 37.2 | 39 | 16 | 16 | 2 | 17 | 40 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 3.08 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 61 | 6 | 6 | 1 | 1 | 4.88 | .411 | 2.06 | 15.3 | 3.7 | 9.0 | 27.2 | 46 | 16 | 15 | 5 | 11 | 27 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.74 |
| SP | Bibee, T.Bibee, Tanner # >> | 26 | 2025 | R | 54 | 6 | 5 | 2 | 4 | 6.07 | .360 | 1.62 | 13.0 | 1.9 | 9.3 | 29.2 | 42 | 20 | 20 | 9 | 6 | 30 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 5.79 |
| RP | Rodríguez, R.Rodríguez, Randy >> | 25 | 2025 | R | 95 | 18 | 0 | 1 | 1 | 6.43 | .308 | 1.29 | 7.7 | 3.9 | 8.1 | 21.0 | 18 | 15 | 15 | 4 | 9 | 19 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 5.10 |
| RP | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 90 | 16 | 0 | 0 | 0 | 0.48 | .291 | 1.18 | 5.0 | 6.0 | 8.0 | 18.2 | 10 | 1 | 1 | 0 | 12 | 16 | 0 | 3 | 0 | 0 | 0 | 1 | 2 | 3.39 |
| RP | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 80 | 14 | 0 | 1 | 0 | 2.25 | .262 | 1.06 | 5.6 | 3.9 | 7.3 | 16.0 | 10 | 4 | 4 | 1 | 7 | 13 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 70 | 8 | 0 | 0 | 0 | 2.25 | .415 | 2.13 | 10.1 | 9.0 | 4.5 | 8.0 | 9 | 3 | 2 | 0 | 8 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.00 |
| RP | Gibson, C.Gibson, Cade >> | 27 | 2025 | L | 49 | 20 | 0 | 2 | 0 | 0.92 | .213 | 0.81 | 4.3 | 3.3 | 9.0 | 19.2 | 9 | 5 | 2 | 2 | 7 | 19 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.47 |
| SP | Bassitt, C.Bassitt, Chris >> | 36 | 2025 | R | 26 | 3 | 0 | 0 | 1 | 3.86 | .364 | 1.71 | 14.1 | 1.3 | 6.4 | 7.0 | 11 | 3 | 3 | 1 | 1 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.86 |