| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 35 | 35 | 18 | 9 | 2.72 | .272 | 1.10 | 7.6 | 2.3 | 10.6 | 238.0 | 201 | 78 | 72 | 20 | 61 | 280 | 1 | 0 | 0 | 1 | 26 | 5 | 3 | 2.57 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 35 | 35 | 15 | 11 | 4.99 | .338 | 1.49 | 10.3 | 3.1 | 10.1 | 193.0 | 221 | 109 | 107 | 27 | 66 | 216 | 1 | 0 | 0 | 0 | 19 | 9 | 6 | 3.75 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 79 | 34 | 34 | 16 | 9 | 4.29 | .338 | 1.46 | 8.8 | 4.4 | 8.2 | 180.1 | 175 | 87 | 86 | 21 | 88 | 163 | 0 | 0 | 0 | 0 | 14 | 13 | 3 | 4.39 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 62 | 33 | 33 | 8 | 11 | 5.25 | .351 | 1.59 | 11.1 | 3.2 | 7.6 | 168.0 | 208 | 102 | 98 | 22 | 59 | 141 | 0 | 0 | 0 | 0 | 15 | 5 | 2 | 4.17 |
| SP | Kershaw, C.Kershaw, Clayton # >> | 37 | 2025 | L | 57 | 37 | 30 | 4 | 8 | 6.28 | .354 | 1.59 | 11.0 | 3.3 | 8.2 | 133.1 | 163 | 96 | 93 | 31 | 49 | 121 | 0 | 3 | 0 | 0 | 6 | 7 | 5 | 5.47 |
| RP | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 92 | 93 | 0 | 4 | 5 | 3.38 | .278 | 1.10 | 7.8 | 2.2 | 9.8 | 130.2 | 112 | 53 | 49 | 16 | 32 | 142 | 0 | 5 | 5 | 0 | 0 | 7 | 2 | 3.32 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 84 | 92 | 0 | 5 | 8 | 6.15 | .333 | 1.45 | 8.8 | 4.3 | 10.6 | 108.1 | 105 | 75 | 74 | 18 | 52 | 127 | 0 | 5 | 5 | 0 | 0 | 5 | 6 | 4.40 |
| RP | Henriquez, R.Henriquez, Ronny >> | 25 | 2025 | R | 78 | 82 | 0 | 4 | 1 | 3.80 | .347 | 1.54 | 9.0 | 5.0 | 11.1 | 94.2 | 94 | 41 | 40 | 6 | 52 | 116 | 0 | 10 | 1 | 0 | 0 | 5 | 5 | 3.18 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 73 | 73 | 0 | 4 | 5 | 5.24 | .320 | 1.39 | 8.9 | 3.7 | 10.0 | 87.2 | 86 | 51 | 51 | 17 | 36 | 97 | 0 | 3 | 3 | 0 | 0 | 2 | 3 | 4.62 |
| SP | Bello, B.Bello, Brayan >> | 26 | 2025 | R | 55 | 43 | 1 | 9 | 8 | 6.55 | .361 | 1.68 | 10.7 | 4.5 | 7.0 | 92.0 | 109 | 69 | 67 | 13 | 46 | 72 | 0 | 6 | 3 | 0 | 1 | 1 | 1 | 4.80 |