| SP | Skubal, T.Skubal, Tarik † # >> | 28 | 2025 | L | 100 | 21 | 21 | 9 | 7 | 2.78 | .268 | 1.06 | 7.4 | 2.1 | 10.2 | 139.0 | 115 | 43 | 43 | 11 | 32 | 157 | 1 | 0 | 0 | 0 | 15 | 6 | 0 | 2.59 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 20 | 20 | 7 | 5 | 5.00 | .316 | 1.35 | 9.6 | 2.6 | 9.6 | 108.0 | 115 | 61 | 60 | 18 | 31 | 115 | 2 | 0 | 0 | 1 | 10 | 4 | 1 | 4.01 |
| SP | Pepiot, R.Pepiot, Ryan >> | 27 | 2025 | R | 78 | 21 | 20 | 7 | 5 | 4.36 | .324 | 1.39 | 8.2 | 4.4 | 10.9 | 107.1 | 97 | 52 | 52 | 18 | 52 | 129 | 0 | 0 | 0 | 0 | 10 | 5 | 2 | 4.37 |
| SP | Williams, G.Williams, Gavin >> | 25 | 2025 | R | 65 | 20 | 20 | 8 | 4 | 5.69 | .356 | 1.65 | 9.3 | 5.6 | 9.5 | 91.2 | 94 | 60 | 58 | 13 | 57 | 96 | 0 | 0 | 0 | 0 | 5 | 1 | 9 | 4.66 |
| SP | Flaherty, J.Flaherty, Jack >> | 29 | 2025 | R | 53 | 21 | 20 | 9 | 6 | 5.77 | .340 | 1.51 | 9.4 | 4.3 | 9.9 | 93.2 | 97 | 60 | 60 | 17 | 44 | 102 | 0 | 0 | 0 | 0 | 5 | 4 | 0 | 4.73 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 59 | 0 | 2 | 1 | 1.70 | .254 | 0.99 | 5.7 | 3.3 | 9.7 | 63.2 | 40 | 12 | 12 | 4 | 23 | 68 | 0 | 24 | 2 | 0 | 0 | 2 | 4 | 2.86 |
| RP | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 88 | 61 | 0 | 10 | 2 | 2.70 | .277 | 1.12 | 6.0 | 4.1 | 11.3 | 76.2 | 51 | 24 | 23 | 2 | 35 | 95 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 2.30 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 79 | 59 | 0 | 7 | 3 | 2.07 | .267 | 1.07 | 6.6 | 3.0 | 11.1 | 74.0 | 54 | 18 | 17 | 5 | 25 | 91 | 0 | 2 | 1 | 0 | 0 | 2 | 6 | 2.51 |
| RP | Gaddis, H.Gaddis, Hunter >> | 27 | 2025 | R | 52 | 52 | 0 | 2 | 2 | 6.05 | .336 | 1.48 | 8.8 | 4.5 | 11.5 | 58.0 | 57 | 39 | 39 | 10 | 29 | 74 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.29 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 69 | 42 | 0 | 1 | 0 | 2.42 | .271 | 1.08 | 8.1 | 1.6 | 7.3 | 52.0 | 47 | 14 | 14 | 3 | 9 | 42 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 2.77 |
| SU | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 45 | 0 | 4 | 0 | 2.89 | .317 | 1.39 | 7.1 | 5.5 | 9.3 | 56.0 | 44 | 18 | 18 | 4 | 34 | 58 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.68 |