| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 20 | 20 | 10 | 7 | 3.38 | .270 | 1.09 | 8.1 | 1.7 | 9.8 | 125.0 | 113 | 47 | 47 | 13 | 23 | 136 | 0 | 0 | 0 | 0 | 14 | 3 | 2 | 2.80 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 19 | 19 | 10 | 4 | 4.55 | .298 | 1.26 | 8.7 | 2.7 | 10.6 | 110.2 | 106 | 56 | 56 | 21 | 33 | 129 | 2 | 0 | 0 | 0 | 9 | 2 | 1 | 4.09 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 87 | 20 | 19 | 8 | 3 | 3.43 | .318 | 1.39 | 7.3 | 5.3 | 10.8 | 94.1 | 76 | 37 | 36 | 10 | 55 | 113 | 0 | 0 | 0 | 0 | 5 | 1 | 4 | 3.77 |
| SP | Cameron, N.Cameron, Noah † # >> | 25 | 2025 | L | 79 | 19 | 19 | 10 | 1 | 3.41 | .250 | 0.98 | 7.3 | 1.6 | 7.6 | 116.0 | 94 | 45 | 44 | 15 | 20 | 98 | 1 | 0 | 0 | 1 | 13 | 2 | 1 | 3.56 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 64 | 18 | 18 | 6 | 6 | 4.35 | .313 | 1.33 | 9.4 | 2.5 | 10.0 | 103.1 | 108 | 53 | 50 | 12 | 29 | 114 | 0 | 0 | 0 | 0 | 7 | 4 | 3 | 3.26 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 51 | 0 | 7 | 3 | 2.65 | .261 | 1.06 | 5.1 | 4.6 | 7.3 | 57.2 | 32 | 17 | 17 | 4 | 29 | 46 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.82 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 69 | 33 | 0 | 2 | 1 | 3.21 | .227 | 0.86 | 6.4 | 1.3 | 7.3 | 42.0 | 30 | 17 | 15 | 6 | 6 | 34 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.74 |
| RP | O'Brien, R.O'Brien, Riley >> | 30 | 2025 | R | 72 | 46 | 0 | 3 | 0 | 2.76 | .342 | 1.44 | 7.9 | 5.1 | 8.8 | 42.1 | 37 | 14 | 13 | 2 | 24 | 41 | 0 | 2 | 0 | 0 | 0 | 5 | 0 | 3.74 |
| RP | Coulombe, D.Coulombe, Daniel >> | 35 | 2025 | L | 65 | 59 | 0 | 2 | 0 | 3.81 | .325 | 1.38 | 7.6 | 5.0 | 9.8 | 56.2 | 47 | 25 | 24 | 8 | 31 | 61 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | 4.55 |
| SU | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 88 | 47 | 0 | 3 | 2 | 1.78 | .248 | 0.99 | 4.5 | 4.5 | 10.8 | 50.2 | 25 | 10 | 10 | 1 | 25 | 60 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 2.36 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 39 | 0 | 2 | 1 | 1.51 | .238 | 0.91 | 4.8 | 3.5 | 13.6 | 41.2 | 22 | 11 | 7 | 0 | 16 | 62 | 0 | 25 | 4 | 0 | 0 | 1 | 2 | 1.22 |
| SP | Flaherty, J.Flaherty, Jack >> | 29 | 2025 | R | 53 | 12 | 0 | 3 | 1 | 2.66 | .317 | 1.35 | 9.8 | 2.7 | 12.5 | 23.2 | 25 | 7 | 7 | 2 | 7 | 32 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 2.39 |