| SP | Skubal, T.Skubal, Tarik † $$ >> | 28 | 2025 | L | 100 | 20 | 20 | 10 | 4 | 2.62 | .252 | 0.99 | 7.0 | 2.0 | 10.6 | 123.2 | 95 | 40 | 36 | 16 | 27 | 145 | 0 | 0 | 0 | 0 | 12 | 3 | 1 | 3.07 |
| SP | Taillon, J.Taillon, Jameson # >> | 33 | 2025 | R | 75 | 19 | 19 | 7 | 5 | 5.55 | .322 | 1.39 | 9.5 | 3.0 | 7.7 | 99.0 | 105 | 68 | 61 | 20 | 33 | 85 | 0 | 0 | 0 | 0 | 6 | 3 | 1 | 5.00 |
| SP | Valdez, F.Valdez, Framber >> | 31 | 2025 | L | 59 | 21 | 19 | 8 | 8 | 4.77 | .322 | 1.39 | 8.9 | 3.7 | 8.0 | 103.2 | 102 | 60 | 55 | 17 | 42 | 91 | 0 | 0 | 0 | 0 | 9 | 4 | 2 | 4.72 |
| CL | Chapman, A.Chapman, Aroldis # >> | 37 | 2025 | L | 100 | 43 | 0 | 2 | 2 | 3.89 | .286 | 1.15 | 7.0 | 3.5 | 11.0 | 41.2 | 32 | 18 | 18 | 7 | 16 | 50 | 0 | 19 | 2 | 0 | 0 | 2 | 4 | 4.10 |
| SU | Cleavinger, G.Cleavinger, Garrett >> | 31 | 2025 | L | 93 | 50 | 0 | 1 | 2 | 2.76 | .260 | 1.04 | 6.4 | 3.0 | 10.7 | 65.1 | 46 | 20 | 20 | 3 | 22 | 77 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 2.29 |
| RP | Uribe, A.Uribe, Abner $ >> | 25 | 2025 | R | 87 | 56 | 0 | 3 | 3 | 4.62 | .298 | 1.23 | 6.0 | 5.1 | 9.8 | 60.1 | 40 | 31 | 31 | 5 | 34 | 65 | 0 | 1 | 2 | 0 | 0 | 3 | 1 | 3.77 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 84 | 44 | 0 | 1 | 1 | 3.94 | .280 | 1.17 | 8.3 | 2.3 | 10.1 | 48.0 | 44 | 21 | 21 | 6 | 12 | 54 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.13 |
| RP | Sousa, B.Sousa, Bennett >> | 30 | 2025 | L | 82 | 63 | 0 | 1 | 4 | 3.31 | .303 | 1.29 | 8.2 | 3.5 | 10.5 | 54.1 | 49 | 20 | 20 | 6 | 21 | 63 | 0 | 1 | 2 | 0 | 0 | 1 | 3 | 3.33 |
| RP | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 75 | 44 | 0 | 6 | 0 | 3.11 | .319 | 1.38 | 7.6 | 4.9 | 9.8 | 46.1 | 39 | 18 | 16 | 2 | 25 | 50 | 0 | 0 | 1 | 0 | 0 | 1 | 4 | 3.09 |