| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 23 | 23 | 18 | 4 | 1.83 | .227 | 0.85 | 6.1 | 1.6 | 9.7 | 157.1 | 106 | 34 | 32 | 8 | 28 | 169 | 1 | 0 | 0 | 0 | 20 | 5 | 1 | 2.14 |
| SP | Crochet, G.Crochet, Garrett # >> | 26 | 2025 | L | 89 | 23 | 23 | 11 | 8 | 3.74 | .259 | 1.02 | 7.6 | 1.7 | 11.3 | 151.2 | 127 | 63 | 63 | 22 | 28 | 189 | 3 | 0 | 0 | 0 | 16 | 4 | 3 | 3.03 |
| SP | Schwellenbach, S.Schwellenbach, Spencer >> | 25 | 2025 | R | 86 | 21 | 21 | 7 | 5 | 3.56 | .299 | 1.24 | 9.0 | 2.2 | 8.9 | 126.1 | 126 | 54 | 50 | 16 | 31 | 125 | 1 | 0 | 0 | 1 | 12 | 5 | 1 | 3.52 |
| RP | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 75 | 60 | 0 | 5 | 0 | 3.10 | .285 | 1.11 | 6.2 | 3.8 | 11.1 | 61.0 | 42 | 22 | 21 | 8 | 26 | 75 | 0 | 1 | 0 | 0 | 0 | 5 | 4 | 3.77 |
| RP | Estrada, J.Estrada, Jeremiah >> | 26 | 2025 | R | 65 | 36 | 0 | 2 | 0 | 6.60 | .366 | 1.63 | 10.5 | 4.2 | 10.5 | 30.0 | 35 | 22 | 22 | 9 | 14 | 35 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 6.27 |
| RP | Romero, J.Romero, JoJo >> | 28 | 2025 | L | 51 | 50 | 0 | 4 | 1 | 2.87 | .277 | 1.13 | 6.3 | 3.8 | 8.0 | 47.0 | 33 | 15 | 15 | 4 | 20 | 42 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.66 |
| RP | Faucher, C.Faucher, Calvin >> | 29 | 2025 | R | 37 | 40 | 0 | 3 | 2 | 3.50 | .341 | 1.47 | 8.8 | 4.5 | 10.0 | 36.0 | 35 | 14 | 14 | 4 | 18 | 40 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 3.97 |
| RP | Bummer, A.Bummer, Aaron >> | 31 | 2025 | L | 33 | 44 | 0 | 1 | 0 | 5.74 | .321 | 1.37 | 9.6 | 2.8 | 7.9 | 42.1 | 45 | 27 | 27 | 7 | 13 | 37 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 4.48 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 52 | 0 | 2 | 3 | 2.37 | .275 | 1.09 | 6.6 | 3.3 | 9.6 | 49.1 | 36 | 13 | 13 | 3 | 18 | 52 | 0 | 37 | 2 | 0 | 0 | 2 | 1 | 2.90 |
| SU | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 46 | 0 | 2 | 3 | 2.96 | .267 | 1.07 | 5.2 | 4.6 | 6.4 | 45.2 | 26 | 19 | 15 | 3 | 23 | 32 | 0 | 3 | 5 | 0 | 0 | 1 | 0 | 4.04 |