| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 8 | 8 | 6 | 2 | 1.89 | .286 | 1.18 | 8.0 | 2.8 | 10.6 | 52.1 | 46 | 13 | 11 | 2 | 16 | 61 | 0 | 0 | 0 | 0 | 7 | 1 | 1 | 2.13 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 8 | 8 | 5 | 1 | 3.33 | .247 | 0.94 | 6.3 | 2.2 | 10.8 | 54.0 | 38 | 20 | 20 | 9 | 13 | 65 | 0 | 0 | 0 | 0 | 6 | 2 | 0 | 3.59 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 79 | 8 | 8 | 4 | 1 | 3.49 | .310 | 1.35 | 8.1 | 4.0 | 7.9 | 49.0 | 44 | 20 | 19 | 2 | 22 | 43 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 3.12 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 64 | 8 | 8 | 4 | 0 | 3.00 | .291 | 1.21 | 7.9 | 3.0 | 9.0 | 48.0 | 42 | 16 | 16 | 4 | 16 | 48 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.15 |
| SP | Flaherty, J.Flaherty, Jack >> | 29 | 2025 | R | 53 | 7 | 7 | 1 | 4 | 6.40 | .349 | 1.58 | 10.1 | 4.2 | 9.8 | 32.1 | 36 | 23 | 23 | 10 | 15 | 35 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 6.38 |
| RP | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 75 | 24 | 0 | 1 | 1 | 1.88 | .287 | 1.17 | 6.8 | 3.8 | 8.6 | 24.0 | 18 | 6 | 5 | 1 | 10 | 23 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 3.00 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 71 | 21 | 0 | 1 | 1 | 1.74 | .303 | 1.31 | 7.2 | 5.0 | 6.3 | 20.2 | 16 | 4 | 4 | 0 | 11 | 14 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3.25 |
| RP | Holton, T.Holton, Tyler >> | 29 | 2025 | L | 63 | 24 | 0 | 1 | 1 | 2.95 | .273 | 1.13 | 8.6 | 1.7 | 9.0 | 21.1 | 20 | 8 | 7 | 1 | 4 | 21 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2.19 |
| RP | Kelly, M.Kelly, Michael >> | 32 | 2025 | R | 36 | 16 | 0 | 2 | 0 | 1.53 | .209 | 0.79 | 5.3 | 2.1 | 6.4 | 17.2 | 10 | 3 | 3 | 2 | 4 | 12 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.82 |
| SU | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 90 | 15 | 0 | 0 | 0 | 3.86 | .276 | 1.14 | 7.7 | 2.6 | 13.5 | 14.0 | 12 | 6 | 6 | 0 | 4 | 21 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0.86 |
| CL | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 16 | 0 | 3 | 0 | 0.96 | .211 | 0.80 | 5.0 | 2.5 | 14.5 | 18.2 | 10 | 2 | 2 | 1 | 5 | 29 | 0 | 9 | 1 | 0 | 0 | 0 | 2 | 1.33 |