| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 36 | 36 | 17 | 12 | 3.06 | .283 | 1.16 | 8.3 | 2.2 | 9.9 | 232.2 | 213 | 84 | 79 | 19 | 57 | 255 | 1 | 0 | 0 | 1 | 26 | 6 | 1 | 2.68 |
| SP | Crochet, G.Crochet, Garrett † >> | 26 | 2025 | L | 89 | 35 | 35 | 17 | 6 | 4.09 | .281 | 1.14 | 8.0 | 2.3 | 10.2 | 204.2 | 182 | 102 | 93 | 32 | 52 | 231 | 0 | 0 | 0 | 0 | 21 | 6 | 4 | 3.63 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 79 | 34 | 34 | 18 | 5 | 3.57 | .300 | 1.27 | 8.5 | 3.0 | 7.0 | 201.2 | 190 | 81 | 80 | 20 | 66 | 156 | 0 | 0 | 0 | 0 | 21 | 3 | 4 | 3.77 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 64 | 33 | 33 | 14 | 8 | 4.59 | .316 | 1.35 | 9.2 | 3.0 | 9.6 | 176.1 | 179 | 91 | 90 | 16 | 59 | 187 | 0 | 0 | 0 | 0 | 17 | 6 | 3 | 3.16 |
| SP | Flaherty, J.Flaherty, Jack >> | 29 | 2025 | R | 53 | 32 | 31 | 9 | 8 | 5.29 | .322 | 1.40 | 8.8 | 3.8 | 9.3 | 153.0 | 150 | 93 | 90 | 29 | 64 | 158 | 0 | 0 | 0 | 0 | 8 | 4 | 2 | 4.73 |
| RP | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 75 | 104 | 0 | 10 | 4 | 2.54 | .298 | 1.24 | 7.1 | 4.1 | 10.4 | 113.1 | 89 | 35 | 32 | 6 | 51 | 131 | 0 | 5 | 1 | 0 | 0 | 4 | 5 | 2.83 |
| RP | Estevez, C.Estevez, Carlos † >> | 32 | 2025 | R | 71 | 89 | 0 | 9 | 3 | 2.26 | .258 | 1.01 | 5.9 | 3.2 | 7.5 | 103.2 | 68 | 26 | 26 | 4 | 37 | 86 | 0 | 4 | 1 | 0 | 0 | 3 | 3 | 3.00 |
| RP | Holton, T.Holton, Tyler >> | 29 | 2025 | L | 63 | 107 | 0 | 5 | 2 | 3.14 | .293 | 1.22 | 8.8 | 2.2 | 8.4 | 97.1 | 95 | 37 | 34 | 12 | 24 | 90 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 3.56 |
| RP | Kelly, M.Kelly, Michael >> | 32 | 2025 | R | 36 | 75 | 0 | 8 | 1 | 3.62 | .307 | 1.31 | 7.4 | 4.4 | 7.4 | 79.2 | 65 | 33 | 32 | 7 | 39 | 65 | 0 | 3 | 2 | 0 | 0 | 2 | 2 | 4.06 |
| SU | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 90 | 79 | 0 | 4 | 0 | 4.18 | .299 | 1.28 | 7.3 | 4.3 | 11.2 | 79.2 | 64 | 39 | 37 | 9 | 38 | 98 | 0 | 3 | 7 | 0 | 0 | 0 | 5 | 3.44 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 79 | 0 | 7 | 2 | 2.02 | .221 | 0.83 | 4.8 | 2.7 | 11.6 | 84.2 | 45 | 19 | 19 | 6 | 25 | 108 | 0 | 44 | 5 | 0 | 0 | 2 | 5 | 2.32 |