| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 9 | 9 | 5 | 1 | 1.44 | .242 | 0.96 | 6.1 | 2.6 | 11.8 | 62.2 | 42 | 11 | 10 | 4 | 18 | 81 | 0 | 0 | 0 | 0 | 8 | 0 | 0 | 2.10 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 9 | 9 | 2 | 6 | 5.16 | .292 | 1.24 | 8.6 | 2.6 | 9.8 | 45.1 | 43 | 26 | 26 | 9 | 13 | 49 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 4.29 |
| SP | Horton, C.Horton, Cade >> | 23 | 2025 | R | 77 | 9 | 9 | 5 | 1 | 3.40 | .284 | 1.17 | 7.7 | 2.9 | 7.4 | 50.1 | 43 | 20 | 19 | 2 | 16 | 41 | 0 | 0 | 0 | 0 | 6 | 1 | 2 | 2.90 |
| SP | Lauer, E.Lauer, Eric # >> | 30 | 2025 | L | 69 | 8 | 8 | 2 | 1 | 6.32 | .293 | 1.24 | 9.6 | 1.7 | 8.4 | 31.1 | 33 | 22 | 22 | 10 | 6 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.90 |
| SP | Kershaw, C.Kershaw, Clayton >> | 37 | 2025 | L | 57 | 8 | 8 | 4 | 1 | 3.72 | .310 | 1.32 | 9.0 | 3.0 | 6.8 | 36.1 | 36 | 16 | 15 | 5 | 12 | 27 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 4.39 |
| RP | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 88 | 26 | 0 | 2 | 3 | 5.46 | .338 | 1.50 | 8.7 | 4.9 | 10.2 | 31.1 | 30 | 20 | 19 | 3 | 17 | 35 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.74 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 79 | 23 | 0 | 1 | 0 | 2.96 | .317 | 1.35 | 10.0 | 2.3 | 10.7 | 27.1 | 30 | 11 | 9 | 2 | 7 | 32 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2.48 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 69 | 18 | 0 | 3 | 0 | 3.26 | .266 | 1.09 | 8.1 | 1.9 | 7.6 | 19.1 | 17 | 7 | 7 | 3 | 4 | 16 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Rodríguez, Y.Rodríguez, Yariel >> | 28 | 2025 | R | 68 | 19 | 0 | 1 | 1 | 3.00 | .259 | 1.05 | 4.3 | 5.1 | 8.1 | 21.0 | 10 | 7 | 7 | 1 | 12 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.52 |
| CL | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 18 | 0 | 1 | 1 | 2.50 | .229 | 0.89 | 5.0 | 3.0 | 16.0 | 18.0 | 10 | 5 | 5 | 2 | 6 | 32 | 0 | 11 | 1 | 0 | 0 | 0 | 0 | 1.89 |
| SU | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 16 | 0 | 1 | 0 | 2.00 | .270 | 1.11 | 7.0 | 3.0 | 7.5 | 18.0 | 14 | 4 | 4 | 2 | 6 | 15 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.78 |