| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 20 | 20 | 10 | 6 | 2.16 | .248 | 0.95 | 6.4 | 2.2 | 10.7 | 141.2 | 100 | 38 | 34 | 8 | 35 | 167 | 2 | 0 | 0 | 2 | 17 | 5 | 1 | 2.22 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 19 | 19 | 10 | 4 | 4.24 | .306 | 1.30 | 9.0 | 2.8 | 10.1 | 116.2 | 116 | 55 | 55 | 16 | 36 | 130 | 1 | 0 | 0 | 1 | 11 | 2 | 3 | 3.53 |
| SP | Glasnow, T.Glasnow, Tyler † >> | 31 | 2025 | R | 87 | 18 | 18 | 10 | 1 | 2.96 | .266 | 1.07 | 6.3 | 3.3 | 10.9 | 100.1 | 70 | 33 | 33 | 10 | 37 | 121 | 0 | 0 | 0 | 0 | 7 | 2 | 1 | 3.05 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 79 | 19 | 19 | 9 | 4 | 3.82 | .273 | 1.08 | 7.9 | 1.8 | 8.0 | 113.0 | 99 | 51 | 48 | 14 | 23 | 101 | 0 | 0 | 0 | 0 | 11 | 5 | 2 | 3.57 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 64 | 19 | 19 | 9 | 7 | 4.65 | .334 | 1.44 | 9.3 | 3.7 | 8.8 | 93.0 | 96 | 49 | 48 | 7 | 38 | 91 | 0 | 0 | 0 | 0 | 7 | 6 | 2 | 3.44 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 47 | 0 | 0 | 2 | 2.37 | .271 | 1.07 | 5.9 | 3.9 | 10.8 | 49.1 | 32 | 13 | 13 | 5 | 21 | 59 | 0 | 28 | 4 | 0 | 0 | 2 | 2 | 3.33 |
| RP | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 88 | 55 | 0 | 7 | 2 | 3.68 | .295 | 1.24 | 7.0 | 4.3 | 9.4 | 63.2 | 49 | 26 | 26 | 7 | 30 | 66 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 3.83 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 44 | 0 | 4 | 0 | 2.77 | .304 | 1.27 | 6.1 | 5.4 | 6.8 | 52.0 | 35 | 16 | 16 | 4 | 31 | 39 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 4.40 |
| RP | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 75 | 40 | 0 | 2 | 0 | 1.42 | .236 | 0.87 | 5.0 | 2.9 | 9.2 | 50.2 | 28 | 9 | 8 | 3 | 16 | 51 | 0 | 2 | 0 | 0 | 0 | 3 | 1 | 2.88 |
| SU | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 92 | 37 | 0 | 2 | 1 | 2.72 | .292 | 1.21 | 6.7 | 4.4 | 9.0 | 39.2 | 29 | 14 | 12 | 1 | 19 | 39 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 2.87 |