| SP | Arrieta, J.Arrieta, Jake $ >> | 29 | 2015 | R | 95 | 33 | 33 | 13 | 11 | 4.42 | .298 | 1.25 | 8.7 | 2.6 | 9.8 | 236.0 | 227 | 122 | 116 | 43 | 69 | 258 | 3 | 0 | 0 | 1 | 19 | 4 | 3 | 4.11 |
| SP | Carrasco, C.Carrasco, Carlos >> | 27 | 2014 | R | 83 | 34 | 34 | 0 | 5 | 4.18 | .323 | 1.41 | 9.6 | 3.0 | 9.1 | 127.0 | 136 | 59 | 59 | 16 | 43 | 129 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 3.69 |
| SP | Bumgarner, M.Bumgarner, Madison # $$ >> | 26 | 2016 | L | 76 | 32 | 32 | 15 | 14 | 5.12 | .331 | 1.45 | 9.8 | 3.3 | 9.8 | 205.2 | 224 | 119 | 117 | 39 | 75 | 224 | 1 | 0 | 0 | 0 | 16 | 6 | 4 | 4.47 |
| SP | Porcello, R.Porcello, Rick >> | 27 | 2016 | R | 56 | 32 | 31 | 12 | 13 | 5.01 | .324 | 1.42 | 9.6 | 3.2 | 7.0 | 208.1 | 221 | 117 | 116 | 31 | 74 | 161 | 2 | 0 | 0 | 0 | 13 | 5 | 5 | 4.53 |
| RP | Doolittle, S.Doolittle, Sean # >> | 31 | 2018 | L | 99 | 86 | 0 | 15 | 2 | 5.29 | .307 | 1.32 | 8.9 | 3.0 | 11.0 | 110.2 | 109 | 67 | 65 | 20 | 37 | 134 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 3.96 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 88 | 76 | 0 | 6 | 3 | 4.04 | .286 | 1.18 | 6.4 | 4.3 | 10.6 | 91.1 | 65 | 41 | 41 | 13 | 43 | 107 | 0 | 5 | 4 | 0 | 0 | 2 | 2 | 3.99 |
| CL | Britton, Z.Britton, Zach † >> | 28 | 2016 | L | 77 | 76 | 0 | 7 | 8 | 3.56 | .310 | 1.31 | 8.4 | 3.5 | 9.6 | 73.1 | 68 | 30 | 29 | 8 | 28 | 78 | 0 | 39 | 7 | 0 | 0 | 3 | 3 | 3.56 |
| RP | Frieri, E.Frieri, Ernesto >> | 26 | 2012 | R | 68 | 55 | 0 | 4 | 2 | 2.30 | .304 | 1.31 | 6.2 | 5.7 | 9.8 | 58.2 | 40 | 16 | 15 | 4 | 37 | 63 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.64 |
| RP | Janssen, C.Janssen, Casey >> | 31 | 2012 | R | 55 | 47 | 0 | 1 | 0 | 3.21 | .270 | 1.09 | 7.3 | 2.7 | 7.7 | 47.2 | 38 | 17 | 17 | 6 | 14 | 40 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 3.91 |