| SP | Hamels, C.Hamels, Cole >> | 34 | 2011 | L | 96 | 23 | 23 | 9 | 4 | 4.42 | .317 | 1.35 | 8.8 | 3.4 | 8.9 | 142.2 | 139 | 70 | 70 | 18 | 54 | 140 | 1 | 0 | 0 | 1 | 12 | 6 | 3 | 3.94 |
| SP | Darvish, Y.Darvish, Yu >> | 34 | 2013 | R | 94 | 23 | 23 | 8 | 9 | 2.89 | .277 | 1.14 | 6.8 | 3.4 | 9.5 | 152.1 | 115 | 55 | 49 | 12 | 58 | 161 | 0 | 0 | 0 | 0 | 19 | 2 | 3 | 3.09 |
| SP | Zambrano, C.Zambrano, Carlos † # >> | 24 | 2005 | R | 91 | 22 | 22 | 13 | 4 | 3.87 | .268 | 1.06 | 6.3 | 3.2 | 7.6 | 151.1 | 106 | 69 | 65 | 21 | 54 | 128 | 3 | 0 | 0 | 1 | 13 | 6 | 4 | 4.30 |
| CL | Marmol, C.Marmol, Carlos † >> | 29 | 2008 | R | 100 | 43 | 0 | 1 | 4 | 3.67 | .286 | 1.18 | 7.2 | 3.5 | 12.7 | 41.2 | 33 | 19 | 17 | 6 | 16 | 58 | 0 | 32 | 6 | 0 | 0 | 1 | 5 | 3.32 |
| SU | Chapman, A.Chapman, Aroldis >> | 35 | 2014 | L | 98 | 41 | 0 | 2 | 3 | 5.45 | .362 | 1.70 | 9.0 | 6.6 | 12.2 | 34.2 | 34 | 24 | 21 | 7 | 25 | 46 | 0 | 0 | 6 | 0 | 0 | 0 | 4 | 5.18 |
| RP | Uehara, K.Uehara, Koji >> | 46 | 2013 | R | 93 | 66 | 0 | 3 | 1 | 2.49 | .269 | 1.11 | 6.1 | 4.0 | 9.7 | 50.2 | 34 | 16 | 14 | 5 | 22 | 54 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 3.46 |
| RP | Wilson, J.Wilson, Justin >> | 33 | 2013 | L | 92 | 52 | 0 | 3 | 0 | 2.70 | .239 | 0.94 | 5.5 | 3.1 | 7.0 | 23.1 | 14 | 7 | 7 | 2 | 8 | 18 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.61 |
| RP | Edwards, C.Edwards, Carl >> | 35 | 2016 | R | 89 | 35 | 0 | 3 | 4 | 2.56 | .258 | 1.04 | 5.5 | 4.1 | 8.4 | 31.2 | 19 | 9 | 9 | 4 | 14 | 29 | 0 | 1 | 2 | 0 | 0 | 0 | 7 | 4.16 |
| RP | Hodge, P.Hodge, Porter >> | 37 | 2024 | R | 89 | 27 | 0 | 2 | 1 | 3.65 | .321 | 1.38 | 7.1 | 5.6 | 6.0 | 24.2 | 19 | 10 | 10 | 0 | 15 | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.67 |
| SP | Hendricks, K.Hendricks, Kyle >> | 37 | 2016 | R | 87 | 14 | 0 | 3 | 1 | 2.47 | .220 | 0.82 | 5.9 | 1.5 | 7.3 | 47.1 | 31 | 13 | 13 | 5 | 8 | 38 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.34 |