| SP | Hamels, C.Hamels, Cole >> | 32 | 2011 | L | 98 | 36 | 36 | 16 | 11 | 3.95 | .298 | 1.25 | 8.6 | 2.6 | 8.0 | 241.2 | 231 | 111 | 106 | 30 | 70 | 214 | 1 | 0 | 0 | 0 | 20 | 7 | 2 | 3.80 |
| SP | Darvish, Y.Darvish, Yu >> | 32 | 2013 | R | 97 | 36 | 36 | 13 | 10 | 4.02 | .310 | 1.33 | 8.3 | 3.7 | 10.7 | 226.0 | 208 | 107 | 101 | 26 | 93 | 269 | 2 | 0 | 0 | 1 | 20 | 3 | 3 | 3.39 |
| SP | Haren, D.Haren, Dan † # >> | 31 | 2009 | R | 95 | 35 | 35 | 17 | 15 | 3.74 | .273 | 1.09 | 7.5 | 2.3 | 8.5 | 243.0 | 202 | 102 | 101 | 29 | 62 | 229 | 4 | 0 | 0 | 1 | 21 | 10 | 10 | 3.56 |
| SP | Hendricks, K.Hendricks, Kyle † >> | 35 | 2016 | R | 89 | 35 | 35 | 18 | 7 | 3.45 | .300 | 1.26 | 8.2 | 3.2 | 7.5 | 219.0 | 199 | 90 | 84 | 19 | 78 | 183 | 0 | 0 | 0 | 0 | 23 | 4 | 3 | 3.58 |
| CL | Chapman, A.Chapman, Aroldis † >> | 33 | 2014 | L | 100 | 72 | 0 | 0 | 5 | 3.05 | .256 | 1.02 | 5.1 | 4.0 | 11.4 | 65.0 | 37 | 24 | 22 | 7 | 29 | 82 | 0 | 49 | 5 | 0 | 0 | 1 | 5 | 3.26 |
| SU | Marmol, C.Marmol, Carlos >> | 27 | 2008 | R | 97 | 96 | 0 | 6 | 5 | 3.89 | .273 | 1.08 | 5.9 | 3.8 | 10.5 | 88.0 | 58 | 39 | 38 | 12 | 37 | 103 | 0 | 0 | 2 | 0 | 0 | 4 | 3 | 3.83 |
| RP | Edwards, C.Edwards, Carl >> | 33 | 2016 | R | 96 | 88 | 0 | 3 | 4 | 4.06 | .304 | 1.29 | 6.7 | 4.9 | 11.0 | 93.0 | 69 | 43 | 42 | 9 | 51 | 114 | 0 | 5 | 6 | 0 | 0 | 2 | 10 | 3.52 |
| RP | Uehara, K.Uehara, Koji >> | 44 | 2013 | R | 96 | 55 | 0 | 4 | 3 | 3.08 | .265 | 1.04 | 7.6 | 1.9 | 10.7 | 52.2 | 44 | 20 | 18 | 6 | 11 | 62 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 2.87 |
| RP | Wilson, J.Wilson, Justin # >> | 31 | 2013 | L | 94 | 87 | 0 | 2 | 4 | 5.12 | .312 | 1.33 | 8.5 | 3.4 | 8.2 | 58.0 | 55 | 34 | 33 | 5 | 22 | 53 | 0 | 0 | 1 | 0 | 0 | 2 | 3 | 3.53 |
| RP | Hodge, P.Hodge, Porter >> | 35 | 2024 | R | 93 | 38 | 0 | 1 | 0 | 4.20 | .404 | 2.00 | 9.6 | 8.4 | 11.7 | 30.0 | 32 | 16 | 14 | 3 | 28 | 39 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 4.60 |
| RP | Germano, J.Germano, Justin >> | 31 | 2010 | R | 90 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |