| SP | Verlander, J.Verlander, Justin † >> | 32 | 2011 | R | 100 | 36 | 36 | 22 | 9 | 2.83 | .259 | 1.02 | 6.8 | 2.4 | 8.4 | 261.0 | 196 | 83 | 82 | 19 | 71 | 244 | 5 | 0 | 0 | 1 | 27 | 7 | 5 | 2.97 |
| SP | Greinke, Z.Greinke, Zack >> | 40 | 2015 | R | 98 | 35 | 35 | 15 | 12 | 4.03 | .295 | 1.23 | 7.9 | 3.2 | 7.7 | 225.1 | 198 | 106 | 101 | 27 | 79 | 192 | 1 | 0 | 0 | 1 | 21 | 6 | 5 | 3.99 |
| SP | McHugh, C.McHugh, Collin † >> | 34 | 2014 | R | 90 | 36 | 36 | 18 | 8 | 2.92 | .268 | 1.05 | 7.2 | 2.2 | 8.2 | 237.0 | 189 | 81 | 77 | 21 | 59 | 217 | 2 | 0 | 0 | 1 | 26 | 12 | 5 | 3.22 |
| SP | Valdez, F.Valdez, Framber >> | 35 | 2018 | L | 87 | 35 | 35 | 15 | 6 | 3.05 | .285 | 1.17 | 5.9 | 4.7 | 6.9 | 191.2 | 126 | 65 | 65 | 18 | 99 | 146 | 0 | 0 | 0 | 0 | 11 | 4 | 6 | 4.31 |
| CL | Gregerson, L.Gregerson, Luke † >> | 29 | 2010 | R | 97 | 77 | 0 | 1 | 3 | 2.38 | .273 | 1.03 | 6.3 | 3.0 | 10.8 | 72.0 | 50 | 19 | 19 | 6 | 24 | 86 | 0 | 61 | 5 | 0 | 0 | 7 | 0 | 2.99 |
| RP | Osuna, R.Osuna, Roberto >> | 28 | 2015 | R | 96 | 74 | 0 | 2 | 6 | 3.01 | .297 | 1.24 | 8.5 | 2.8 | 9.7 | 83.2 | 78 | 29 | 28 | 9 | 26 | 89 | 0 | 5 | 7 | 0 | 0 | 2 | 4 | 3.28 |
| RP | Valverde, J.Valverde, Jose >> | 28 | 2007 | R | 92 | 95 | 0 | 8 | 4 | 2.87 | .299 | 1.24 | 7.8 | 3.5 | 9.7 | 87.2 | 75 | 28 | 28 | 7 | 34 | 94 | 0 | 1 | 3 | 0 | 0 | 3 | 0 | 3.16 |
| RP | Trivino, L.Trivino, Lou >> | 37 | 2018 | R | 83 | 31 | 0 | 1 | 4 | 5.60 | .354 | 1.54 | 9.3 | 4.7 | 8.7 | 27.1 | 28 | 17 | 17 | 5 | 14 | 26 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 5.37 |
| SP | Keuchel, D.Keuchel, Dallas >> | 35 | 2015 | L | 85 | 20 | 2 | 1 | 1 | 2.34 | .264 | 1.02 | 7.0 | 2.3 | 8.5 | 84.2 | 65 | 22 | 22 | 11 | 21 | 79 | 0 | 0 | 0 | 0 | 2 | 5 | 1 | 3.75 |