| SP | Verlander, J.Verlander, Justin >> | 34 | 2011 | R | 99 | 23 | 23 | 11 | 10 | 3.25 | .276 | 1.10 | 7.5 | 2.4 | 7.2 | 166.0 | 138 | 60 | 60 | 11 | 45 | 132 | 2 | 0 | 0 | 1 | 15 | 7 | 2 | 3.21 |
| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 98 | 23 | 23 | 9 | 6 | 3.30 | .266 | 1.05 | 6.5 | 3.0 | 6.9 | 155.2 | 112 | 59 | 57 | 11 | 51 | 119 | 0 | 0 | 0 | 0 | 16 | 6 | 4 | 3.49 |
| SP | Greinke, Z.Greinke, Zack >> | 42 | 2015 | R | 97 | 23 | 23 | 10 | 6 | 3.80 | .301 | 1.26 | 9.1 | 2.3 | 5.6 | 139.2 | 140 | 61 | 59 | 11 | 36 | 87 | 2 | 0 | 0 | 0 | 12 | 4 | 3 | 3.64 |
| SP | Pettitte, A.Pettitte, Andy † # >> | 33 | 2005 | L | 91 | 22 | 22 | 9 | 8 | 3.32 | .251 | 0.99 | 6.9 | 2.0 | 7.6 | 152.0 | 117 | 59 | 56 | 18 | 34 | 128 | 6 | 0 | 0 | 1 | 15 | 2 | 0 | 3.57 |
| SP | Cole, G.Cole, Gerrit † >> | 42 | 2019 | R | 91 | 22 | 22 | 13 | 6 | 2.31 | .265 | 1.04 | 6.5 | 2.9 | 11.3 | 128.2 | 93 | 35 | 33 | 8 | 41 | 160 | 0 | 0 | 0 | 0 | 12 | 5 | 0 | 2.39 |
| CL | Gregerson, L.Gregerson, Luke † >> | 31 | 2010 | R | 99 | 42 | 0 | 0 | 0 | 1.89 | .240 | 0.95 | 5.4 | 3.1 | 9.7 | 38.0 | 23 | 8 | 8 | 4 | 13 | 41 | 0 | 37 | 3 | 0 | 0 | 0 | 0 | 3.24 |
| SU | Osuna, R.Osuna, Roberto >> | 30 | 2015 | R | 98 | 47 | 0 | 0 | 3 | 2.36 | .263 | 1.07 | 6.4 | 3.4 | 8.0 | 45.2 | 32 | 12 | 12 | 5 | 17 | 40 | 0 | 2 | 3 | 0 | 0 | 0 | 2 | 3.80 |
| RP | Valverde, J.Valverde, Jose # >> | 30 | 2007 | R | 91 | 53 | 0 | 5 | 2 | 4.89 | .292 | 1.22 | 7.0 | 3.9 | 11.5 | 46.0 | 36 | 25 | 25 | 7 | 20 | 59 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 3.78 |
| RP | Nieve, F.Nieve, Fernando >> | 25 | 2006 | R | 76 | 35 | 0 | 3 | 3 | 5.05 | .349 | 1.49 | 9.0 | 4.4 | 6.4 | 41.0 | 41 | 24 | 23 | 7 | 20 | 29 | 0 | 0 | 2 | 0 | 0 | 5 | 2 | 5.63 |
| RP | Brocail, D.Brocail, Doug >> | 42 | 2007 | R | 69 | 20 | 0 | 1 | 2 | 9.00 | .346 | 1.53 | 10.6 | 3.2 | 4.8 | 17.0 | 20 | 17 | 17 | 6 | 6 | 9 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 7.76 |
| SP | McHugh, C.McHugh, Collin >> | 36 | 2014 | R | 86 | 14 | 0 | 3 | 0 | 2.70 | .268 | 1.08 | 7.0 | 2.7 | 8.5 | 50.0 | 39 | 16 | 15 | 9 | 15 | 47 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.42 |