| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 19 | 19 | 6 | 8 | 3.21 | .289 | 1.19 | 8.3 | 2.4 | 8.9 | 120.2 | 111 | 43 | 43 | 11 | 32 | 118 | 0 | 0 | 0 | 0 | 14 | 4 | 2 | 3.13 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 80 | 18 | 18 | 5 | 8 | 4.81 | .321 | 1.38 | 9.3 | 3.1 | 8.1 | 86.0 | 89 | 49 | 46 | 16 | 30 | 77 | 0 | 0 | 0 | 0 | 4 | 3 | 1 | 4.78 |
| SP | Lodolo, N.Lodolo, Nick † >> | 27 | 2025 | L | 76 | 19 | 18 | 10 | 4 | 3.29 | .309 | 1.29 | 9.0 | 2.7 | 11.0 | 101.1 | 101 | 37 | 37 | 19 | 30 | 123 | 0 | 0 | 0 | 0 | 8 | 5 | 1 | 4.05 |
| SP | Littell, Z.Littell, Zack † >> | 29 | 2025 | R | 60 | 19 | 17 | 10 | 4 | 3.43 | .319 | 1.38 | 9.9 | 2.5 | 8.8 | 110.1 | 121 | 44 | 42 | 9 | 31 | 107 | 0 | 0 | 0 | 0 | 9 | 3 | 0 | 3.05 |
| SP | Woods Richardson, S.Woods Richardson, Simeon >> | 24 | 2025 | R | 56 | 19 | 18 | 5 | 5 | 4.76 | .332 | 1.46 | 8.9 | 4.3 | 9.6 | 81.1 | 80 | 43 | 43 | 11 | 39 | 86 | 0 | 0 | 0 | 0 | 2 | 2 | 5 | 4.16 |
| RP | Speier, G.Speier, Gabe >> | 30 | 2025 | L | 96 | 43 | 0 | 2 | 0 | 2.42 | .233 | 0.87 | 6.4 | 1.3 | 10.1 | 67.0 | 48 | 18 | 18 | 6 | 10 | 75 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 2.51 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 44 | 0 | 3 | 1 | 2.73 | .282 | 1.15 | 7.8 | 2.6 | 7.8 | 59.1 | 51 | 18 | 18 | 7 | 17 | 51 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 3.78 |
| RP | Sousa, B.Sousa, Bennett >> | 30 | 2025 | L | 82 | 48 | 0 | 2 | 2 | 2.76 | .279 | 1.16 | 7.6 | 2.9 | 9.9 | 58.2 | 49 | 18 | 18 | 8 | 19 | 64 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.57 |
| RP | Estrada, J.Estrada, Jeremiah >> | 26 | 2025 | R | 65 | 36 | 0 | 4 | 2 | 2.68 | .284 | 1.19 | 7.3 | 3.4 | 11.9 | 37.0 | 30 | 11 | 11 | 4 | 14 | 49 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.89 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 84 | 33 | 0 | 5 | 1 | 2.23 | .245 | 0.97 | 5.6 | 3.2 | 9.2 | 48.1 | 30 | 12 | 12 | 3 | 17 | 49 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.83 |
| CL | Bednar, D.Bednar, David † >> | 30 | 2025 | R | 79 | 32 | 0 | 0 | 0 | 2.48 | .295 | 1.16 | 8.2 | 2.5 | 13.2 | 32.2 | 29 | 10 | 9 | 3 | 9 | 47 | 0 | 19 | 3 | 0 | 0 | 3 | 0 | 2.41 |
| RP | Banks, T.Banks, Tanner >> | 33 | 2025 | L | 71 | 23 | 0 | 2 | 1 | 4.67 | .296 | 1.26 | 8.7 | 2.7 | 7.0 | 27.0 | 26 | 14 | 14 | 4 | 8 | 21 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.26 |