| SP | Skubal, T.Skubal, Tarik $$ >> | 28 | 2025 | L | 100 | 6 | 6 | 2 | 1 | 3.86 | .296 | 1.21 | 8.8 | 2.3 | 11.1 | 39.2 | 38 | 17 | 17 | 4 | 10 | 48 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 2.79 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 6 | 6 | 2 | 2 | 5.66 | .327 | 1.43 | 10.0 | 2.8 | 10.0 | 35.0 | 39 | 22 | 22 | 11 | 11 | 39 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 5.89 |
| SP | Lodolo, N.Lodolo, Nick # >> | 27 | 2025 | L | 76 | 6 | 6 | 2 | 2 | 4.96 | .315 | 1.35 | 7.9 | 4.5 | 10.1 | 32.2 | 28 | 20 | 18 | 7 | 16 | 36 | 0 | 0 | 0 | 0 | 2 | 1 | 3 | 5.19 |
| SP | Cabrera, E.Cabrera, Edward >> | 27 | 2025 | R | 66 | 6 | 6 | 2 | 0 | 4.23 | .325 | 1.41 | 9.0 | 4.0 | 11.0 | 27.2 | 27 | 13 | 13 | 5 | 12 | 33 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 4.41 |
| SP | Valdez, F.Valdez, Framber >> | 31 | 2025 | L | 59 | 6 | 6 | 4 | 0 | 3.68 | .281 | 1.12 | 7.0 | 3.3 | 6.5 | 36.2 | 28 | 16 | 15 | 3 | 13 | 26 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 3.89 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 90 | 15 | 0 | 3 | 0 | 2.25 | .318 | 1.35 | 6.8 | 5.4 | 8.6 | 20.0 | 15 | 5 | 5 | 3 | 12 | 19 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.00 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 12 | 0 | 1 | 2 | 2.87 | .299 | 1.28 | 8.4 | 3.6 | 9.0 | 15.2 | 14 | 5 | 5 | 1 | 6 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.07 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 12 | 0 | 2 | 0 | 2.63 | .241 | 0.88 | 4.2 | 4.2 | 12.5 | 13.2 | 6 | 4 | 4 | 1 | 6 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.85 |
| SU | Keller, B.Keller, Brad >> | 29 | 2025 | R | 91 | 15 | 0 | 1 | 2 | 2.60 | .246 | 0.98 | 7.4 | 1.6 | 9.0 | 17.1 | 14 | 7 | 5 | 3 | 3 | 17 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.82 |