| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 33 | 33 | 15 | 8 | 3.21 | .259 | 1.03 | 7.1 | 2.2 | 10.7 | 219.0 | 172 | 81 | 78 | 23 | 53 | 261 | 2 | 0 | 0 | 1 | 24 | 5 | 1 | 2.78 |
| SP | Rodon, C.Rodon, Carlos # >> | 32 | 2025 | L | 90 | 32 | 32 | 14 | 10 | 3.22 | .280 | 1.15 | 7.8 | 2.5 | 9.8 | 204.0 | 177 | 73 | 73 | 25 | 57 | 221 | 0 | 0 | 0 | 0 | 20 | 4 | 1 | 3.32 |
| SP | Horton, C.Horton, Cade >> | 23 | 2025 | R | 77 | 31 | 31 | 8 | 13 | 5.54 | .339 | 1.53 | 9.9 | 3.9 | 8.4 | 156.0 | 172 | 97 | 96 | 30 | 67 | 145 | 0 | 0 | 0 | 0 | 9 | 1 | 7 | 4.95 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 64 | 30 | 30 | 10 | 9 | 3.98 | .304 | 1.27 | 8.5 | 2.9 | 10.2 | 171.2 | 162 | 82 | 76 | 23 | 56 | 193 | 0 | 0 | 0 | 0 | 18 | 7 | 3 | 3.60 |
| RP | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 80 | 83 | 0 | 6 | 2 | 2.97 | .253 | 1.00 | 6.6 | 2.4 | 10.2 | 109.0 | 80 | 36 | 36 | 12 | 29 | 123 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 3.03 |
| RP | Banks, T.Banks, Tanner >> | 33 | 2025 | L | 71 | 72 | 0 | 4 | 1 | 5.26 | .313 | 1.34 | 8.8 | 3.4 | 8.4 | 75.1 | 73 | 45 | 44 | 11 | 28 | 70 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 4.24 |
| RP | Herget, J.Herget, Jimmy >> | 31 | 2025 | R | 53 | 60 | 0 | 7 | 2 | 3.16 | .285 | 1.17 | 7.8 | 2.8 | 7.4 | 85.1 | 74 | 30 | 30 | 14 | 26 | 70 | 0 | 2 | 1 | 0 | 0 | 2 | 4 | 4.48 |
| RP | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 90 | 52 | 0 | 2 | 3 | 3.76 | .304 | 1.25 | 6.9 | 4.4 | 11.0 | 55.0 | 42 | 25 | 23 | 5 | 27 | 67 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 3.38 |
| SU | Keller, B.Keller, Brad >> | 29 | 2025 | R | 91 | 71 | 0 | 2 | 1 | 3.03 | .298 | 1.22 | 7.1 | 3.9 | 11.4 | 71.1 | 56 | 24 | 24 | 4 | 31 | 90 | 0 | 3 | 5 | 0 | 0 | 4 | 0 | 2.68 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 68 | 0 | 3 | 9 | 3.20 | .280 | 1.09 | 6.4 | 3.5 | 11.1 | 70.1 | 50 | 26 | 25 | 8 | 27 | 86 | 0 | 41 | 6 | 0 | 0 | 5 | 0 | 3.40 |
| SP | Burrows, M.Burrows, Mike >> | 25 | 2025 | R | 58 | 5 | 0 | 1 | 2 | 19.06 | .500 | 3.00 | 25.2 | 5.4 | 16.2 | 5.2 | 14 | 12 | 12 | 3 | 3 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 9.00 |