| SP | Jimenez, U.Jimenez, Ubaldo # >> | 26 | 2010 | R | 60 | 32 | 32 | 11 | 10 | 4.27 | .310 | 1.32 | 7.6 | 4.3 | 6.4 | 211.0 | 178 | 104 | 100 | 17 | 101 | 151 | 2 | 0 | 0 | 0 | 20 | 6 | 9 | 4.14 |
| SP | Marquez, G.Marquez, German # >> | 23 | 2018 | R | 49 | 31 | 31 | 13 | 11 | 4.99 | .324 | 1.41 | 9.7 | 3.0 | 8.6 | 180.1 | 194 | 103 | 100 | 20 | 60 | 171 | 1 | 0 | 0 | 0 | 15 | 5 | 6 | 3.63 |
| SP | Gomber, A.Gomber, Austin >> | 27 | 2021 | L | 45 | 31 | 31 | 12 | 10 | 4.04 | .307 | 1.31 | 8.1 | 3.7 | 5.6 | 167.0 | 150 | 75 | 75 | 13 | 68 | 103 | 0 | 0 | 0 | 0 | 7 | 4 | 2 | 4.07 |
| SP | Chacin, J.Chacin, Jhoulys >> | 22 | 2010 | R | 47 | 29 | 29 | 9 | 7 | 5.16 | .334 | 1.50 | 9.3 | 4.3 | 6.1 | 141.1 | 145 | 85 | 81 | 16 | 67 | 95 | 0 | 0 | 0 | 0 | 5 | 1 | 2 | 4.57 |
| RP | Ottavino, A.Ottavino, Adam >> | 32 | 2018 | R | 69 | 74 | 0 | 5 | 5 | 3.45 | .295 | 1.25 | 6.7 | 4.6 | 7.9 | 104.1 | 77 | 40 | 40 | 8 | 53 | 91 | 0 | 3 | 3 | 0 | 0 | 1 | 6 | 3.81 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 64 | 76 | 0 | 6 | 10 | 3.35 | .277 | 1.13 | 8.0 | 2.3 | 9.6 | 96.2 | 85 | 39 | 36 | 9 | 24 | 102 | 0 | 6 | 6 | 0 | 0 | 2 | 0 | 2.91 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 60 | 68 | 0 | 6 | 5 | 4.64 | .268 | 1.08 | 8.0 | 1.8 | 8.9 | 75.2 | 67 | 39 | 39 | 10 | 15 | 74 | 0 | 12 | 3 | 0 | 0 | 1 | 0 | 3.40 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 59 | 40 | 0 | 3 | 3 | 3.12 | .234 | 0.92 | 5.6 | 2.7 | 8.3 | 40.1 | 25 | 14 | 14 | 3 | 12 | 37 | 0 | 5 | 1 | 0 | 0 | 0 | 4 | 3.03 |
| RP | DeJean, M.DeJean, Mike >> | 35 | 2005 | R | 42 | 22 | 0 | 0 | 0 | 0.68 | .252 | 1.01 | 4.8 | 4.5 | 4.2 | 26.2 | 14 | 2 | 2 | 0 | 13 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.58 |
| SP | De La Rosa, J.De La Rosa, Jorge >> | 29 | 2010 | L | 35 | 26 | 0 | 5 | 3 | 4.79 | .315 | 1.36 | 7.5 | 4.8 | 5.0 | 118.1 | 98 | 69 | 63 | 19 | 63 | 65 | 0 | 0 | 0 | 0 | 0 | 2 | 6 | 5.64 |