| SP | Scherzer, M.Scherzer, Max † >> | 37 | 2021 | R | 100 | 24 | 24 | 16 | 1 | 2.41 | .277 | 1.13 | 6.5 | 3.6 | 8.9 | 183.0 | 133 | 52 | 49 | 10 | 73 | 180 | 3 | 0 | 0 | 0 | 18 | 4 | 0 | 3.01 |
| SP | Youmans, F.Youmans, Floyd † >> | 22 | 1986 | R | 59 | 24 | 23 | 11 | 6 | 3.39 | .313 | 1.35 | 7.5 | 4.7 | 5.8 | 156.2 | 130 | 62 | 59 | 13 | 82 | 100 | 2 | 1 | 0 | 0 | 15 | 2 | 4 | 4.42 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 98 | 23 | 23 | 11 | 8 | 3.49 | .273 | 1.10 | 6.8 | 3.1 | 8.2 | 183.0 | 139 | 74 | 71 | 14 | 63 | 167 | 16 | 0 | 0 | 2 | 15 | 4 | 3 | 3.27 |
| SP | Perez, P.Perez, Pascual # >> | 31 | 1988 | R | 86 | 22 | 22 | 12 | 6 | 4.11 | .314 | 1.35 | 9.2 | 3.0 | 5.8 | 166.1 | 169 | 80 | 76 | 19 | 55 | 107 | 5 | 0 | 0 | 1 | 12 | 4 | 7 | 4.27 |
| SP | Strasburg, S.Strasburg, Stephen # >> | 24 | 2013 | R | 70 | 22 | 21 | 10 | 5 | 4.83 | .315 | 1.37 | 9.8 | 2.6 | 7.8 | 130.1 | 141 | 71 | 70 | 23 | 37 | 113 | 2 | 0 | 0 | 0 | 9 | 2 | 2 | 4.46 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 56 | 0 | 7 | 1 | 1.04 | .200 | 0.72 | 4.5 | 2.1 | 10.6 | 34.2 | 17 | 4 | 4 | 2 | 8 | 40 | 0 | 2 | 5 | 0 | 0 | 1 | 2 | 2.21 |
| RP | Reardon, J.Reardon, Jeff † >> | 26 | 1981 | R | 88 | 57 | 0 | 9 | 0 | 2.22 | .245 | 0.96 | 5.9 | 2.7 | 5.5 | 73.0 | 48 | 19 | 18 | 5 | 22 | 45 | 0 | 10 | 0 | 0 | 0 | 1 | 1 | 3.60 |
| RP | Albers, M.Albers, Matt >> | 34 | 2017 | R | 81 | 24 | 0 | 1 | 0 | 2.45 | .318 | 1.40 | 8.4 | 4.3 | 8.1 | 29.1 | 27 | 8 | 8 | 3 | 14 | 26 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 83 | 37 | 0 | 3 | 2 | 2.93 | .283 | 1.16 | 7.5 | 2.9 | 6.9 | 43.0 | 36 | 15 | 14 | 3 | 14 | 33 | 0 | 6 | 1 | 0 | 0 | 1 | 1 | 3.42 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 84 | 23 | 0 | 3 | 1 | 3.55 | .283 | 1.18 | 9.4 | 1.4 | 9.0 | 25.1 | 26 | 15 | 10 | 5 | 4 | 25 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 4.08 |