| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 22 | 22 | 14 | 5 | 3.22 | .287 | 1.19 | 8.3 | 2.5 | 8.9 | 156.2 | 143 | 63 | 56 | 14 | 43 | 154 | 4 | 0 | 0 | 0 | 18 | 3 | 3 | 3.08 |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 89 | 21 | 21 | 13 | 4 | 4.28 | .307 | 1.30 | 9.4 | 2.2 | 5.4 | 141.0 | 148 | 73 | 67 | 15 | 35 | 85 | 2 | 0 | 0 | 0 | 13 | 4 | 1 | 4.01 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 21 | 21 | 4 | 6 | 6.41 | .359 | 1.67 | 11.6 | 3.5 | 4.8 | 98.1 | 126 | 74 | 70 | 20 | 38 | 52 | 0 | 0 | 0 | 0 | 4 | 1 | 3 | 5.79 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 21 | 20 | 6 | 7 | 5.09 | .349 | 1.58 | 10.0 | 4.4 | 5.3 | 123.2 | 136 | 77 | 70 | 20 | 60 | 72 | 1 | 0 | 0 | 0 | 10 | 3 | 7 | 5.48 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 42 | 0 | 0 | 0 | 2.04 | .217 | 0.81 | 5.5 | 1.8 | 8.1 | 39.2 | 24 | 9 | 9 | 1 | 8 | 35 | 0 | 34 | 1 | 0 | 0 | 1 | 0 | 2.23 |
| SU | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 45 | 0 | 0 | 3 | 4.71 | .300 | 1.29 | 8.3 | 3.5 | 7.9 | 49.2 | 45 | 29 | 26 | 11 | 19 | 43 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 5.33 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 48 | 0 | 2 | 3 | 4.65 | .341 | 1.50 | 9.2 | 4.5 | 10.4 | 40.2 | 41 | 23 | 21 | 4 | 20 | 46 | 0 | 0 | 3 | 0 | 0 | 2 | 2 | 3.65 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 55 | 0 | 4 | 3 | 4.58 | .289 | 1.19 | 5.3 | 5.5 | 7.4 | 39.1 | 23 | 20 | 20 | 4 | 24 | 32 | 0 | 2 | 2 | 0 | 0 | 1 | 4 | 4.62 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 38 | 0 | 5 | 3 | 3.55 | .294 | 1.23 | 8.4 | 2.8 | 10.0 | 45.2 | 42 | 21 | 18 | 8 | 14 | 50 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.09 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 29 | 0 | 5 | 0 | 4.61 | .349 | 1.61 | 7.7 | 7.0 | 6.0 | 27.1 | 23 | 15 | 14 | 3 | 21 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 5.44 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 30 | 0 | 0 | 0 | 4.50 | .303 | 1.22 | 7.8 | 3.3 | 7.3 | 36.0 | 31 | 20 | 18 | 8 | 13 | 29 | 0 | 2 | 0 | 0 | 0 | 3 | 2 | 5.61 |