| SP | Cole, G.Cole, Gerrit † # >> | 28 | 2019 | R | 92 | 22 | 22 | 13 | 2 | 1.94 | .251 | 0.98 | 6.9 | 2.0 | 8.5 | 134.1 | 102 | 33 | 29 | 6 | 30 | 126 | 0 | 0 | 0 | 0 | 12 | 3 | 2 | 2.44 |
| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 22 | 22 | 7 | 10 | 3.77 | .273 | 1.09 | 7.2 | 2.7 | 8.7 | 121.2 | 97 | 52 | 51 | 11 | 36 | 117 | 0 | 0 | 0 | 0 | 9 | 4 | 0 | 3.24 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 21 | 21 | 8 | 8 | 4.97 | .291 | 1.21 | 9.2 | 1.7 | 7.9 | 117.2 | 120 | 66 | 65 | 23 | 22 | 103 | 0 | 0 | 0 | 0 | 10 | 3 | 0 | 4.44 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 21 | 21 | 6 | 8 | 5.83 | .328 | 1.44 | 11.1 | 1.9 | 3.2 | 117.1 | 144 | 77 | 76 | 17 | 25 | 41 | 2 | 0 | 0 | 1 | 7 | 3 | 0 | 4.91 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 57 | 0 | 5 | 1 | 1.81 | .246 | 0.97 | 4.8 | 4.0 | 8.2 | 79.2 | 42 | 17 | 16 | 3 | 35 | 72 | 0 | 5 | 2 | 0 | 0 | 1 | 2 | 3.04 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 46 | 0 | 9 | 2 | 3.15 | .301 | 1.28 | 7.9 | 3.7 | 8.3 | 65.2 | 57 | 24 | 23 | 6 | 27 | 60 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 3.65 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 29 | 0 | 1 | 1 | 2.12 | .271 | 1.12 | 5.3 | 4.8 | 7.1 | 34.0 | 20 | 8 | 8 | 2 | 18 | 27 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 3.76 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 69 | 19 | 0 | 2 | 0 | 3.38 | .340 | 1.55 | 10.3 | 3.9 | 3.4 | 21.1 | 24 | 8 | 8 | 3 | 9 | 8 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.38 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 16 | 0 | 1 | 0 | 2.12 | .301 | 1.29 | 6.4 | 5.3 | 7.9 | 17.0 | 12 | 4 | 4 | 2 | 10 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.53 |