| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 90 | 26 | 26 | 13 | 8 | 3.34 | .256 | 1.02 | 7.4 | 1.8 | 8.6 | 188.2 | 154 | 73 | 70 | 18 | 38 | 180 | 6 | 0 | 0 | 2 | 19 | 3 | 1 | 2.98 |
| SP | Gallen, Z.Gallen, Zac † >> | 26 | 2022 | R | 94 | 26 | 26 | 13 | 4 | 2.41 | .249 | 0.96 | 6.1 | 2.6 | 8.5 | 175.1 | 119 | 49 | 47 | 17 | 50 | 166 | 2 | 0 | 0 | 2 | 21 | 5 | 2 | 3.31 |
| SP | Kelly, M.Kelly, Merrill >> | 31 | 2020 | R | 62 | 25 | 25 | 1 | 4 | 2.47 | .278 | 1.14 | 7.4 | 2.9 | 6.4 | 69.1 | 57 | 24 | 19 | 10 | 22 | 49 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 4.46 |
| SP | Greinke, Z.Greinke, Zack >> | 36 | 2019 | R | 77 | 25 | 25 | 8 | 8 | 3.28 | .285 | 1.17 | 8.2 | 2.4 | 5.8 | 145.1 | 132 | 60 | 53 | 16 | 38 | 94 | 0 | 0 | 0 | 0 | 13 | 4 | 3 | 4.01 |
| SP | Gilbert, T.Gilbert, Tyler >> | 27 | 2021 | L | 65 | 25 | 24 | 0 | 2 | 2.37 | .289 | 1.18 | 6.0 | 4.6 | 4.9 | 64.2 | 43 | 18 | 17 | 9 | 33 | 35 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 5.42 |
| RP | Ramirez, N.Ramirez, Noe # >> | 31 | 2021 | R | 72 | 65 | 0 | 12 | 7 | 4.83 | .296 | 1.23 | 7.4 | 3.7 | 7.1 | 85.2 | 70 | 47 | 46 | 17 | 35 | 67 | 0 | 6 | 4 | 0 | 0 | 3 | 4 | 5.36 |
| RP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 73 | 62 | 0 | 11 | 5 | 3.23 | .272 | 1.10 | 7.5 | 2.4 | 6.1 | 133.2 | 111 | 49 | 48 | 12 | 36 | 90 | 0 | 4 | 6 | 0 | 0 | 3 | 5 | 3.70 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 75 | 50 | 0 | 7 | 3 | 2.33 | .289 | 1.19 | 6.5 | 4.3 | 9.6 | 65.2 | 47 | 19 | 17 | 4 | 31 | 69 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 3.20 |
| RP | Ginkel, K.Ginkel, Kevin >> | 29 | 2023 | R | 64 | 40 | 0 | 1 | 2 | 3.06 | .261 | 1.02 | 5.6 | 3.6 | 6.5 | 50.0 | 31 | 18 | 17 | 3 | 20 | 36 | 0 | 9 | 1 | 0 | 0 | 2 | 0 | 3.66 |
| RP | Curtiss, J.Curtiss, John >> | 32 | 2025 | R | 49 | 32 | 0 | 2 | 2 | 4.33 | .279 | 1.10 | 8.2 | 1.8 | 5.9 | 35.1 | 32 | 17 | 17 | 6 | 7 | 23 | 0 | 7 | 1 | 0 | 0 | 2 | 0 | 4.69 |
| RP | Crichton, S.Crichton, Stefan >> | 27 | 2019 | R | 47 | 23 | 0 | 1 | 0 | 1.59 | .269 | 1.06 | 7.8 | 2.0 | 7.0 | 22.2 | 19 | 4 | 4 | 2 | 5 | 17 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.45 |
| RP | Rodney, F.Rodney, Fernando >> | 40 | 2017 | R | 41 | 22 | 0 | 1 | 0 | 1.98 | .204 | 0.73 | 2.7 | 4.0 | 7.0 | 27.1 | 8 | 6 | 6 | 1 | 12 | 21 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 3.37 |