| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 89 | 36 | 36 | 18 | 10 | 3.26 | .263 | 1.05 | 7.4 | 2.1 | 8.9 | 254.0 | 209 | 95 | 92 | 20 | 58 | 250 | 3 | 0 | 0 | 2 | 24 | 5 | 3 | 2.80 |
| SP | McLain, D.McLain, Denny † >> | 24 | 1968 | R | 82 | 35 | 35 | 18 | 11 | 4.17 | .318 | 1.38 | 9.7 | 2.7 | 6.4 | 248.1 | 267 | 119 | 115 | 24 | 75 | 176 | 13 | 0 | 0 | 1 | 18 | 6 | 6 | 3.82 |
| SP | Scherzer, M.Scherzer, Max # >> | 29 | 2013 | R | 75 | 33 | 33 | 17 | 12 | 4.76 | .325 | 1.42 | 9.4 | 3.4 | 8.7 | 193.0 | 202 | 107 | 102 | 19 | 73 | 186 | 0 | 0 | 0 | 0 | 14 | 4 | 4 | 3.55 |
| SP | Lolich, M.Lolich, Mickey >> | 28 | 1968 | L | 54 | 31 | 31 | 10 | 10 | 5.46 | .345 | 1.56 | 10.2 | 3.8 | 7.3 | 130.1 | 148 | 81 | 79 | 15 | 55 | 106 | 0 | 0 | 0 | 0 | 11 | 3 | 7 | 4.21 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 80 | 85 | 0 | 8 | 5 | 3.67 | .299 | 1.27 | 6.9 | 4.5 | 9.2 | 108.0 | 83 | 44 | 44 | 13 | 54 | 110 | 0 | 6 | 2 | 0 | 0 | 1 | 0 | 4.06 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 72 | 78 | 0 | 3 | 0 | 2.74 | .312 | 1.33 | 6.9 | 5.1 | 8.8 | 102.0 | 78 | 31 | 31 | 4 | 58 | 100 | 0 | 6 | 3 | 0 | 0 | 3 | 6 | 3.34 |
| RP | McMahon, D.McMahon, Don # >> | 38 | 1968 | R | 71 | 72 | 0 | 4 | 7 | 4.87 | .296 | 1.24 | 8.0 | 3.2 | 6.9 | 101.2 | 90 | 57 | 55 | 16 | 36 | 77 | 0 | 14 | 2 | 0 | 0 | 2 | 1 | 4.66 |
| RP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 60 | 49 | 0 | 3 | 5 | 4.17 | .302 | 1.30 | 9.4 | 2.5 | 5.8 | 77.2 | 80 | 41 | 36 | 12 | 21 | 50 | 0 | 6 | 3 | 0 | 0 | 0 | 0 | 4.55 |
| RP | Miller, S.Miller, Shelby >> | 33 | 2024 | R | 49 | 29 | 0 | 1 | 2 | 5.40 | .336 | 1.48 | 10.2 | 3.5 | 5.2 | 31.2 | 35 | 19 | 19 | 3 | 12 | 18 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.35 |
| RP | Podres, J.Podres, Johnny >> | 35 | 1967 | L | 33 | 28 | 0 | 1 | 2 | 4.68 | .329 | 1.44 | 8.7 | 4.5 | 6.2 | 32.2 | 31 | 19 | 17 | 4 | 16 | 22 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 4.84 |
| RP | Lasher, F.Lasher, Fred >> | 26 | 1967 | R | 35 | 29 | 0 | 0 | 0 | 4.66 | .377 | 1.79 | 11.3 | 4.9 | 7.4 | 46.1 | 58 | 26 | 24 | 4 | 25 | 38 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.17 |