| SP | Lamet, D.Lamet, Dinelson >> | 27 | 2020 | R | 100 | 28 | 28 | 0 | 4 | 2.96 | .274 | 1.11 | 7.2 | 2.7 | 8.8 | 76.0 | 61 | 27 | 25 | 4 | 23 | 74 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 2.72 |
| SP | Pivetta, N.Pivetta, Nick >> | 32 | 2025 | R | 82 | 28 | 28 | 14 | 11 | 3.80 | .292 | 1.21 | 8.0 | 2.9 | 8.3 | 175.1 | 156 | 77 | 74 | 14 | 56 | 162 | 0 | 0 | 0 | 0 | 15 | 5 | 3 | 3.23 |
| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 88 | 27 | 27 | 14 | 10 | 3.77 | .277 | 1.14 | 7.8 | 2.5 | 8.4 | 174.1 | 150 | 73 | 73 | 16 | 48 | 162 | 2 | 0 | 0 | 0 | 17 | 2 | 0 | 3.20 |
| SP | Paddack, C.Paddack, Chris >> | 23 | 2019 | R | 78 | 27 | 27 | 11 | 9 | 4.26 | .291 | 1.19 | 8.4 | 2.4 | 8.2 | 145.2 | 136 | 69 | 69 | 23 | 38 | 132 | 0 | 0 | 0 | 0 | 13 | 5 | 2 | 4.13 |
| SP | Pomeranz, D.Pomeranz, Drew >> | 27 | 2016 | L | 80 | 27 | 27 | 13 | 4 | 2.85 | .265 | 1.07 | 6.3 | 3.3 | 7.8 | 173.2 | 122 | 59 | 55 | 8 | 64 | 150 | 0 | 0 | 0 | 0 | 19 | 2 | 3 | 3.01 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 98 | 60 | 0 | 6 | 1 | 1.54 | .243 | 0.94 | 4.9 | 3.5 | 6.0 | 82.0 | 45 | 19 | 14 | 6 | 32 | 55 | 0 | 6 | 1 | 0 | 0 | 2 | 1 | 3.85 |
| RP | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 95 | 52 | 0 | 4 | 2 | 3.02 | .251 | 0.99 | 6.5 | 2.5 | 8.0 | 62.2 | 45 | 21 | 21 | 2 | 17 | 55 | 0 | 11 | 2 | 0 | 0 | 1 | 3 | 2.52 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 85 | 33 | 0 | 0 | 1 | 2.90 | .280 | 1.17 | 7.9 | 2.7 | 7.2 | 40.1 | 35 | 14 | 13 | 1 | 12 | 32 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 2.63 |
| RP | Castillo, J.Castillo, Jose >> | 22 | 2018 | L | 78 | 24 | 0 | 2 | 1 | 2.30 | .299 | 1.18 | 6.7 | 4.1 | 8.4 | 31.1 | 23 | 8 | 8 | 1 | 14 | 29 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 3.19 |
| SP | Young, C.Young, Chris † >> | 28 | 2007 | R | 73 | 30 | 0 | 16 | 6 | 2.79 | .271 | 1.11 | 5.7 | 4.3 | 6.2 | 161.1 | 102 | 53 | 50 | 13 | 77 | 111 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.12 |