| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 99 | 29 | 29 | 17 | 4 | 3.55 | .299 | 1.25 | 8.5 | 2.8 | 8.4 | 207.2 | 195 | 88 | 82 | 24 | 65 | 193 | 5 | 0 | 0 | 2 | 17 | 6 | 4 | 3.67 |
| SP | Keller, B.Keller, Brad # >> | 29 | 2025 | R | 91 | 27 | 26 | 0 | 4 | 5.40 | .356 | 1.61 | 9.9 | 4.8 | 7.0 | 41.2 | 45 | 25 | 25 | 5 | 22 | 32 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.78 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 89 | 28 | 28 | 17 | 6 | 3.79 | .312 | 1.36 | 9.2 | 3.0 | 6.2 | 204.0 | 209 | 91 | 86 | 18 | 69 | 141 | 6 | 0 | 0 | 0 | 17 | 0 | 4 | 3.78 |
| SP | Wesneski, H.Wesneski, Hayden >> | 24 | 2022 | R | 92 | 27 | 27 | 0 | 1 | 3.44 | .281 | 1.16 | 8.2 | 2.3 | 7.5 | 70.2 | 64 | 31 | 27 | 7 | 18 | 58 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.46 |
| SP | Ramsdell, W.Ramsdell, Willie >> | 36 | 1952 | R | 83 | 27 | 27 | 0 | 2 | 3.33 | .287 | 1.21 | 7.4 | 3.5 | 5.1 | 73.0 | 60 | 28 | 27 | 7 | 28 | 41 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.27 |
| RP | Hodge, P.Hodge, Porter † >> | 23 | 2024 | R | 89 | 66 | 0 | 20 | 4 | 3.09 | .273 | 1.13 | 6.6 | 3.6 | 9.0 | 93.1 | 68 | 36 | 32 | 9 | 37 | 93 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 3.45 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 33 | 2021 | R | 100 | 63 | 0 | 5 | 6 | 2.63 | .278 | 1.14 | 4.9 | 5.4 | 10.5 | 68.1 | 37 | 20 | 20 | 2 | 41 | 79 | 0 | 32 | 4 | 0 | 0 | 1 | 5 | 2.91 |
| SU | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 97 | 64 | 0 | 6 | 0 | 1.81 | .219 | 0.80 | 3.4 | 3.9 | 8.9 | 79.2 | 30 | 16 | 16 | 5 | 34 | 78 | 0 | 3 | 4 | 0 | 0 | 3 | 6 | 3.25 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 94 | 65 | 0 | 7 | 1 | 3.61 | .304 | 1.30 | 7.4 | 4.4 | 8.6 | 84.2 | 69 | 34 | 34 | 6 | 41 | 80 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 3.52 |
| RP | Miller, T.Miller, Tyson † >> | 28 | 2024 | R | 79 | 66 | 0 | 17 | 2 | 2.71 | .223 | 0.86 | 5.3 | 2.4 | 6.8 | 93.0 | 55 | 31 | 28 | 9 | 25 | 70 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 3.56 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 59 | 52 | 0 | 4 | 3 | 2.62 | .255 | 1.01 | 7.6 | 1.5 | 6.6 | 65.1 | 55 | 20 | 19 | 7 | 11 | 48 | 0 | 1 | 4 | 0 | 0 | 1 | 3 | 3.48 |
| RP | Weaver, H.Weaver, Harry >> | 26 | 1918 | R | 42 | 47 | 0 | 4 | 0 | 3.26 | .295 | 1.24 | 8.7 | 2.5 | 4.2 | 91.0 | 88 | 36 | 33 | 8 | 25 | 42 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 4.08 |