| SP | McLain, D.McLain, Denny † >> | 24 | 1968 | R | 93 | 29 | 29 | 20 | 7 | 2.65 | .250 | 0.98 | 6.7 | 2.1 | 5.9 | 234.0 | 175 | 73 | 69 | 20 | 55 | 154 | 17 | 0 | 0 | 4 | 21 | 4 | 3 | 3.55 |
| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 98 | 28 | 28 | 16 | 5 | 3.20 | .272 | 1.09 | 8.2 | 1.6 | 8.9 | 200.0 | 183 | 73 | 71 | 15 | 35 | 198 | 1 | 0 | 0 | 1 | 20 | 6 | 1 | 2.61 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 86 | 27 | 27 | 14 | 7 | 4.24 | .322 | 1.41 | 8.9 | 3.8 | 8.4 | 174.0 | 172 | 91 | 82 | 22 | 73 | 163 | 2 | 0 | 0 | 1 | 16 | 3 | 3 | 4.08 |
| SP | Lolich, M.Lolich, Mickey >> | 28 | 1968 | L | 65 | 27 | 27 | 10 | 11 | 5.24 | .329 | 1.46 | 9.7 | 3.5 | 6.8 | 142.2 | 153 | 87 | 83 | 18 | 55 | 108 | 0 | 0 | 0 | 0 | 11 | 2 | 1 | 4.33 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 87 | 69 | 0 | 5 | 0 | 3.18 | .313 | 1.36 | 7.3 | 5.0 | 9.1 | 87.2 | 71 | 32 | 31 | 8 | 48 | 88 | 0 | 8 | 4 | 0 | 0 | 1 | 0 | 3.86 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 82 | 70 | 0 | 4 | 0 | 3.36 | .285 | 1.20 | 7.0 | 3.8 | 8.4 | 80.1 | 62 | 30 | 30 | 9 | 34 | 75 | 0 | 13 | 4 | 0 | 0 | 0 | 3 | 3.86 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 74 | 45 | 0 | 5 | 3 | 3.33 | .295 | 1.24 | 6.6 | 4.7 | 7.9 | 67.2 | 49 | 25 | 25 | 7 | 35 | 59 | 0 | 7 | 4 | 0 | 0 | 1 | 7 | 4.21 |
| RP | Alburquerque, A.Alburquerque, Al # >> | 25 | 2011 | R | 68 | 32 | 0 | 5 | 2 | 5.03 | .315 | 1.38 | 7.1 | 5.3 | 9.3 | 34.0 | 27 | 23 | 19 | 6 | 20 | 35 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 5.00 |
| RP | Miller, S.Miller, Shelby >> | 33 | 2024 | R | 58 | 24 | 0 | 1 | 0 | 1.16 | .205 | 0.77 | 4.4 | 2.6 | 5.8 | 31.0 | 15 | 5 | 4 | 1 | 9 | 20 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Podres, J.Podres, Johnny >> | 35 | 1967 | L | 39 | 37 | 0 | 1 | 4 | 5.96 | .350 | 1.59 | 11.6 | 2.8 | 5.1 | 48.1 | 62 | 34 | 32 | 7 | 15 | 27 | 0 | 5 | 2 | 0 | 0 | 1 | 5 | 4.77 |