| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 92 | 14 | 14 | 8 | 3 | 2.80 | .258 | 1.02 | 7.1 | 2.2 | 8.9 | 99.2 | 78 | 34 | 31 | 11 | 24 | 98 | 1 | 0 | 0 | 1 | 11 | 2 | 1 | 3.25 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 87 | 14 | 14 | 7 | 4 | 4.99 | .311 | 1.35 | 9.4 | 2.8 | 4.0 | 97.1 | 101 | 59 | 54 | 14 | 30 | 43 | 7 | 0 | 0 | 1 | 6 | 1 | 3 | 4.95 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 76 | 14 | 14 | 8 | 2 | 4.84 | .307 | 1.32 | 9.1 | 2.8 | 8.3 | 87.1 | 88 | 48 | 47 | 12 | 27 | 80 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 3.92 |
| SP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 82 | 13 | 13 | 0 | 5 | 4.59 | .301 | 1.26 | 10.1 | 1.4 | 6.3 | 33.1 | 37 | 17 | 17 | 8 | 5 | 23 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.30 |
| SP | Flaherty, J.Flaherty, Jack # >> | 28 | 2024 | R | 75 | 13 | 13 | 6 | 6 | 3.74 | .265 | 1.08 | 7.4 | 2.4 | 7.4 | 79.1 | 65 | 33 | 33 | 11 | 21 | 65 | 0 | 0 | 0 | 0 | 7 | 0 | 2 | 3.96 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 87 | 31 | 0 | 2 | 0 | 2.93 | .241 | 0.95 | 6.5 | 2.1 | 8.8 | 43.0 | 31 | 14 | 14 | 6 | 10 | 42 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 3.56 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 61 | 24 | 0 | 1 | 2 | 2.31 | .266 | 1.09 | 6.4 | 3.3 | 6.4 | 35.0 | 25 | 9 | 9 | 2 | 13 | 25 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 3.43 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 55 | 12 | 0 | 1 | 1 | 5.51 | .269 | 1.04 | 6.2 | 3.4 | 7.3 | 16.1 | 11 | 10 | 10 | 3 | 6 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.13 |
| RP | Miller, S.Miller, Shelby >> | 33 | 2024 | R | 39 | 12 | 0 | 1 | 0 | 3.00 | .250 | 1.00 | 7.2 | 1.8 | 4.8 | 15.0 | 12 | 5 | 5 | 3 | 3 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.13 |
| RP | Suggs, G.Suggs, George >> | 27 | 1909 | R | 35 | 16 | 0 | 2 | 0 | 2.41 | .291 | 1.23 | 8.5 | 3.0 | 7.0 | 18.2 | 17 | 6 | 5 | 2 | 6 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.89 |
| SP | Lolich, M.Lolich, Mickey >> | 28 | 1968 | L | 55 | 13 | 0 | 8 | 1 | 4.09 | .278 | 1.13 | 7.0 | 3.3 | 5.1 | 72.2 | 56 | 34 | 33 | 13 | 26 | 41 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 5.38 |