| SP | Buchholz, C.Buchholz, Clay † >> | 34 | 2018 | R | 69 | 28 | 28 | 15 | 8 | 3.90 | .301 | 1.27 | 8.9 | 2.5 | 7.1 | 184.2 | 182 | 82 | 80 | 20 | 52 | 145 | 1 | 0 | 0 | 0 | 19 | 5 | 3 | 3.77 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 68 | 29 | 29 | 7 | 12 | 4.04 | .289 | 1.21 | 8.0 | 2.9 | 6.2 | 149.1 | 132 | 68 | 67 | 15 | 48 | 103 | 0 | 0 | 0 | 0 | 8 | 2 | 3 | 3.93 |
| SP | Kelly, M.Kelly, Merrill >> | 33 | 2022 | R | 64 | 28 | 28 | 9 | 8 | 4.15 | .315 | 1.34 | 8.6 | 3.5 | 6.7 | 180.0 | 172 | 88 | 83 | 17 | 70 | 134 | 0 | 0 | 0 | 0 | 14 | 6 | 5 | 4.01 |
| SP | Johnson, R.Johnson, Randy # >> | 45 | 2008 | L | 38 | 28 | 27 | 7 | 10 | 4.47 | .325 | 1.41 | 9.8 | 2.9 | 7.8 | 163.0 | 178 | 89 | 81 | 14 | 52 | 142 | 0 | 0 | 0 | 0 | 16 | 5 | 2 | 3.42 |
| SP | Webb, B.Webb, Brandon # >> | 25 | 2004 | R | 26 | 26 | 26 | 9 | 12 | 4.79 | .356 | 1.64 | 9.4 | 5.5 | 6.2 | 148.1 | 154 | 94 | 79 | 13 | 90 | 102 | 0 | 0 | 0 | 0 | 6 | 2 | 15 | 4.63 |
| RP | Kim, B.Kim, Byung-Hyun >> | 22 | 2001 | R | 70 | 81 | 0 | 4 | 3 | 2.61 | .267 | 1.07 | 5.5 | 4.1 | 8.5 | 124.1 | 76 | 36 | 36 | 5 | 57 | 117 | 0 | 6 | 5 | 0 | 0 | 3 | 7 | 3.09 |
| RP | Ziegler, B.Ziegler, Brad >> | 36 | 2015 | R | 60 | 81 | 0 | 7 | 6 | 3.74 | .293 | 1.24 | 7.8 | 3.3 | 5.6 | 108.1 | 94 | 46 | 45 | 9 | 40 | 67 | 0 | 6 | 4 | 0 | 0 | 1 | 2 | 3.98 |
| RP | Bradley, A.Bradley, Archie >> | 24 | 2017 | R | 56 | 75 | 0 | 3 | 7 | 5.42 | .334 | 1.48 | 10.4 | 3.0 | 8.9 | 86.1 | 99 | 55 | 52 | 14 | 29 | 85 | 0 | 9 | 3 | 0 | 0 | 2 | 0 | 4.22 |
| RP | Valverde, J.Valverde, Jose >> | 28 | 2007 | R | 53 | 50 | 0 | 7 | 1 | 2.08 | .272 | 1.07 | 6.8 | 3.0 | 9.2 | 60.2 | 45 | 15 | 14 | 5 | 20 | 61 | 0 | 3 | 1 | 0 | 0 | 3 | 0 | 3.20 |
| RP | Villarreal, O.Villarreal, Oscar >> | 22 | 2003 | R | 25 | 48 | 0 | 2 | 1 | 2.17 | .305 | 1.31 | 7.8 | 4.2 | 6.2 | 45.2 | 39 | 11 | 11 | 2 | 21 | 31 | 0 | 7 | 0 | 0 | 0 | 0 | 1 | 3.60 |