| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 96 | 31 | 31 | 14 | 7 | 3.64 | .285 | 1.15 | 7.5 | 2.9 | 8.0 | 183.0 | 153 | 76 | 74 | 16 | 58 | 163 | 0 | 0 | 0 | 0 | 18 | 8 | 0 | 3.44 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 93 | 30 | 30 | 13 | 9 | 4.24 | .313 | 1.32 | 9.1 | 2.8 | 8.8 | 199.1 | 201 | 96 | 94 | 18 | 63 | 195 | 2 | 0 | 0 | 0 | 14 | 9 | 1 | 3.30 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 81 | 30 | 30 | 9 | 9 | 3.82 | .307 | 1.31 | 8.7 | 3.2 | 5.1 | 197.2 | 190 | 89 | 84 | 15 | 69 | 112 | 5 | 0 | 0 | 3 | 15 | 4 | 4 | 3.96 |
| SP | Schatzeder, D.Schatzeder, Dan >> | 30 | 1984 | L | 50 | 31 | 30 | 1 | 10 | 6.73 | .369 | 1.73 | 11.3 | 4.4 | 3.9 | 105.2 | 132 | 86 | 79 | 15 | 51 | 45 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 5.51 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 63 | 0 | 6 | 2 | 3.06 | .281 | 1.16 | 8.2 | 2.3 | 9.3 | 70.2 | 64 | 27 | 24 | 3 | 18 | 72 | 0 | 24 | 10 | 0 | 0 | 1 | 2 | 2.31 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 88 | 89 | 0 | 8 | 5 | 3.21 | .293 | 1.22 | 7.7 | 3.4 | 5.2 | 148.2 | 126 | 57 | 53 | 12 | 56 | 85 | 0 | 6 | 2 | 0 | 0 | 3 | 7 | 4.10 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 86 | 77 | 0 | 10 | 4 | 2.99 | .266 | 1.09 | 6.4 | 3.4 | 7.9 | 108.1 | 77 | 36 | 36 | 11 | 41 | 95 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 3.70 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 83 | 67 | 0 | 3 | 2 | 3.61 | .306 | 1.30 | 8.2 | 3.5 | 8.2 | 92.1 | 84 | 40 | 37 | 4 | 36 | 84 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 2.98 |
| RP | Albers, M.Albers, Matt >> | 34 | 2017 | R | 80 | 53 | 0 | 7 | 3 | 4.93 | .321 | 1.42 | 8.7 | 4.2 | 7.9 | 65.2 | 63 | 36 | 36 | 6 | 30 | 57 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.83 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 73 | 58 | 0 | 7 | 4 | 5.35 | .330 | 1.45 | 9.7 | 3.5 | 9.3 | 65.2 | 70 | 40 | 39 | 6 | 25 | 67 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.38 |